Adrebloc100 mg/10 ml

IV Injection

Esmolol Hydrochloride

ZAS Corporation

Product Code : 351
MRP 350.00
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Medicine overview

Indications of Adrebloc 100 mg/10 ml

Adrebloc 100 mg/10 ml is a beta adrenergic blocker indicated for the short-termtreatment of: Control of ventricular rate in supraventricular tachycardia including atrial fibrillation and atrial flutter and control of heart rate in noncompensatory sinus tachycardia. Control of perioperative tachycardia and hypertension.

Dosage of Adrebloc 100 mg/10 ml

Administer intravenously. Titrate using ventricular rate or blood pressure at ≥4 minute intervals. Supraventricular tachycardia (SVT) or noncompensatory sinus tachycardia- Optional loading dose: 500 mcg per kg infused over one minute Then 50 mcg per kg per minute for the next 4 minutes Adjust dose as needed to a maximum of 200 mcg per kg per minute Additional loading doses may be administered Perioperative tachycardia and hypertension- Loading dose: 500 mcg per kg over 1 minute for gradual control (1 mg per kg over 30 seconds for immediate control). Than 50 mcg per kg per minute for gradual control (150 mcg per kg per minute for immediate control) adjusted to a maximum of 200 (tachycardia) or 300 (hypertension) mcg per kg per minute.

Interaction of Adrebloc 100 mg/10 ml

Digitalis glycosides: Risk of bradycardia Anticholinesterases: Prolongs neuromuscular blockade Antihypertensive agents: Risk of rebound hypertension Sympathomimetic drugs: Dose adjustment needed Vasoconstrictive and positive inotropic effect substances: Avoid concomitant use


Severe sinus bradycardia Heart block greater than first degree Sick sinus syndrome Decompensated heart failure Cardiogenic shock Coadministration of IV cardiodepressant calcium-channel antagonists (e.g. verapamil) in close proximity to Esmolol hydrochloride Pulmonary hypertension Known hypersensitivity to esmolol

Side Effects of Adrebloc 100 mg/10 ml

Most common adverse reactions (incidence> 10%) are symptomatic hypotension (hyperhidrosis, dizziness) and asymptomatic hypotension.

Precautions & Warnings

Risk of hypotension, bradycardia, and cardiac failure: Reduce or discontinue use Risk of exacerbating reactive airway disease Diabetes mellitus: Increases the effect of hypoglycemic agents and masks hypoglycemic tachycardia Risk of unopposed alpha-agonism and severe hypertension in untreated pheochromocytoma Risk of myocardial ischemia when abruptly discontinued in patients with coronary artery disease

Storage Conditions

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.

Drug Classes

Anti adrenergic agent (Beta blockers)

Mode Of Action

Adrebloc 100 mg/10 ml is a beta-1 selective (cardioselective) adrenergic receptor blocking agent with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilizing activity at therapeutic dosages. Its elimination half-life after intravenous infusion is approximately 9 minutes. Adrebloc 100 mg/10 ml inhibits the beta 1 receptors located chiefly in cardiac muscle, but this preferential effect is not absolute and at higher doses it begins to inhibit beta 2 receptors located chiefly in the bronchial and vascular musculature.


Pregnancy Category C. Esmolol hydrochloride has been shown to produce increased fetal resorptions with minimal maternal toxicity in rabbits when given in doses approximately 8 times the maximum human maintenance dose (300 mcg/kg/min). There are no adequate and well-controlled studies in pregnant women. Adrebloc 100 mg/10 ml should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Adrebloc 100 mg/10 ml, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Uses

Pediatric Use: The safety and effectiveness of Adrebloc 100 mg/10 ml in pediatric patients have not been established.Geriatric Use: Clinical studies of Adrebloc 100 mg/10 ml did not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger subjects. Hepatic Impairment: No special precautions are necessary in patients with hepatic impairment because Adrebloc 100 mg/10 ml is metabolized by red-blood cell esterases.Renal Impairment: No dosage adjustment is required for esmolol in patients with renal impairment receiving a maintenance infusion of esmolol 150 mcg/kg for 4 hours.

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.