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ADS20000 IU/5 ml

Injection

Diphtheria Antitoxin
ByCSL Behring
MRP ৳ 182.555% Off
Best PriceTk 173.42/5 ml vial
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Medicine overview

Indications of ADS 20000 IU/5 ml

This is indicated in Diphtheria hypersensitivity test, Mild to moderate nasal diphtheria, Mild to moderate tonsillar diphtheria, Mild to moderate pharyngeal or laryngeal diphtheria, Severe diphtheria, Mild to moderate cutaneous diphtheria, Diphtheria hypersensitivity test, Desensitisation of diphtheria hypersensitivity

Theropeutic Class

Vaccines, Anti-sera & Immunoglobulin

Pharmacology

Diptherias antitoxin is used, often concurrently with an antibiotic, for passive immunisation against suspected diphtheria infection. It contains specific globulins which negate the local and systemic effects of toxins produced by Corynebacterium diptheriae.

Dosage & Administration of ADS 20000 IU/5 ml

Intradermal- Diphtheria hypersensitivity test: 0.1 ml of ADS 20000 IU/5 ml (equine) in 0.9% sodium chloride in a 1:100 dilution. Skin test read 20 minutes later. If patient has a history of allergy: 0.05 ml of a 1:1000 dilution. An inj of 0.9% sodium chloride can be used as a control. A positive reaction is represented by an urticarial wheal, with or without pseudopods, with a zone of erythema. Intravenous- Mild to moderate nasal diphtheria: 10000-20000 units via slow IV infusion.Mild to moderate tonsillar diphtheria: 15000-25000 units via slow IV infusion.Mild to moderate pharyngeal or laryngeal diphtheria: 20000-40000 units via slow IV infusion.Severe diphtheria: Up to 100000 units by slow IV infusion.Mild to moderate cutaneous diphtheria: Only used if ulcer >2 cm2 (insufficiently absorbed in smaller ulcers). Dose: 20000-40000 units by slow IV infusion. Subcutaneous- Desensitisation of diphtheria hypersensitivity: Diphtheria antitoxin (equine) is administered in incremental doses every 15 minutes: 0.05 ml of a 1:20 dilution, 0.1 ml of 1:10 dilution, 0.3 ml of a 1:10 dilution and 0.1 ml of undiluted antitoxin. After another 15 minutes, 0.5 ml of undiluted antitoxin is administered IM or IV.

Side Effects of ADS 20000 IU/5 ml

Serum sickness (type III hypersensitivity reaction) up to 12 days after antitoxin admin, symptoms include: Urticaria, fever, pruritus, malaise, skin rash and arthralgia. Accelerated serum sickness (occurring <7 days after immunisation) may occur in individuals with previous admin of equine serum.

Pregnancy & Lactation

No data found

Precautions & Warnings

History of asthma. Test doses should be administered before immunisation to eliminate hypersensitivity. Adrenaline inj and resuscitation facilities should be available after all immunisation. Not used for diphtheria prophylaxis because of hypersensitivity risk. A negative sensitivity test dose so not completely exclude systemic sensitivity. If hypersensitivity occurs during or immediately after desensitisation procedure, a tourniquet should be applied and adrenaline administered next to the site of inj.

Storage Conditions

Store at 2-8° C, do not freeze.

Frequently Asked Questions

What is ADS 20000 IU/5 ml used for?

This is indicated in Diphtheria hypersensitivity test, Mild to moderate nasal diphtheria, Mild to moderate tonsillar diphtheria, Mild to moderate pharyngeal or laryngeal diphtheria, Severe diphtheria, Mild to moderate cutaneous diphtheria, Diphtheria hypersensitivity test, Desensitisation of diphtheria hypersensitivity

What is the dosage of ADS 20000 IU/5 ml?

Intradermal- Diphtheria hypersensitivity test: 0.1 ml of ADS 20000 IU/5 ml (equine) in 0.9% sodium chloride in a 1:100 dilution. Skin test read 20 minutes later. If patient has a history of allergy: 0.05 ml of a 1:1000 dilution. An inj of 0.9% sodium chloride can be used as a control. A positive reaction is represented by an urticarial wheal, with or without pseudopods, with a zone of erythema. In…

What are the side effects of ADS 20000 IU/5 ml?

Serum sickness (type III hypersensitivity reaction) up to 12 days after antitoxin admin, symptoms include: Urticaria, fever, pruritus, malaise, skin rash and arthralgia. Accelerated serum sickness (occurring <7 days after immunisation) may occur in individuals with previous admin of equine serum.

What precautions should be taken with ADS 20000 IU/5 ml?

History of asthma. Test doses should be administered before immunisation to eliminate hypersensitivity. Adrenaline inj and resuscitation facilities should be available after all immunisation. Not used for diphtheria prophylaxis because of hypersensitivity risk. A negative sensitivity test dose so not completely exclude systemic sensitivity. If hypersensitivity occurs during or immediately after de…

Is ADS 20000 IU/5 ml safe during pregnancy and breastfeeding?

No data found

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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