Anvert25 mg+50 mg


Meclizine + Pyridoxine

Orion Pharma Ltd.

Product Code : 1134
MRP 3.01
10% Off
Best PriceTk

Medicine overview

Indications of Anvert 25 mg+50 mg

Prevention and treatment of nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of the vestibular system (e.g. Meniere's syndrome, labyrinthitis and other vestibular disturbances).

Theropeutic Class

Anti-emetic drugs


Meclizine Hydrochloride prevents nausea and vomiting by reducing the activity of the center in the brain that controls nausea. It also prevents motion sickness by reducing excitability of neurons in the vestibular region of the brain. Pyridoxine Hydrochloride (vit. B6), either alone or combination has been used to prevent nausea and vomiting due to its antiemetic properties.

Dosage & Administration of Anvert 25 mg+50 mg

Nausea and vomiting during pregnancy: 1 tablet 1-2 times daily (after taking food) or as directed by the physician. Nausea and vomiting after surgery: 1-2 tablets daily.Nausea and vomiting induced by irradiation: 1 tablet (shortly before or after the irradiation). Motion sickness: 1-2 tablets one hour prior to journey. This dose may be repeated every 24 hours, if required.Vertigo associated with vestibular system diseases: 1 tablet 2 times daily or as required.

Dosage of Anvert 25 mg+50 mg

Adult and Children 12 years of age & over: Nausea and vomiting: 25-50 mg daily or as directed by a physician. Motion sickness: Take an initial dose of 25-50 mg, 1 hour prior to travel. May repeat the dose every 24 hours for the duration of the journey. Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment. Vertigo: 25-100 mg daily in divided doses. Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP): 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours. The safety and efficacy for use in children less than 12 years of age have not been established.

Interaction of Anvert 25 mg+50 mg

The CNS depressant effects of Meclizine can be potentiated by concurrent use of Ethanol or other CNS depressant agents such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants and antihistamines. Concurrent use of other anticholinergics can potentiate the anticholinergic effects of Meclizine. Meclizine can increase the absorption of digoxin by decreasing gastrointestinal motility.


Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.

Side Effects of Anvert 25 mg+50 mg

Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.

Pregnancy & Lactation

There is no evidence of adverse effects of this combination on pregnancy or on the health of the fetus or neonate. But account should be taken with the use of antihistamines to just before the parturition. Pyridoxine is considered as safe in pregnancy. Pyridoxine is excreted in human milk but meclizine is unknown whether it is excreted or not. So, this combination may be indicated during lactation, if clearly needed.

Precautions & Warnings

Patients should be warned that Meclizine Hydrochloride may impair their ability to perform hazardous activities requiring mental alertness or physical coordination (e.g., operating machinery, driving a motor vehicle). Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland.

Overdose Effects of Anvert 25 mg+50 mg

Symptoms: Extreme excitability, seizures, drowsiness and hallucinations.Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Drug Classes

Anti-emetic drugs

Mode Of Action

Meclizine is a piperazine-derivative antihistamine that is used as an antiemetic. It has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Pyridoxine is vitamin B-6. It has been added to enhance the anti-emetic effects & as a dietary suppliment.


Pregnancy Category B. Large-scale human studies have not demonstrated adverse fetal effects. It has been suggested that based on available data, Meclizine presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy. Safety for use in the nursing mother has not been established.

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.