Indications of Atechlor 100 mg+25 mg
This combination is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.
Combined antihypertensive preparations
Atenolol is a beta1-selective (cardio selective) beta-adrenergic receptor blocking agentwithout membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities.This preferential effect is not absolute, however, and at higher doses, Atenolol inhibitsbeta-2-adrenoreceptors, chiefly located in the bronchial and vascular musculature.ChlorthalidoneChlorthalidone is a monosulfonamyl double ring system which differs chemically fromthiazide diuretics in that a double ring system is incorporated in its' structure. It is an oraldiuretic with prolonged action and low toxicity. The diuretic of the drug occurs within 2 hours of an oral dose. It produces diuresis with greatly increased excretion of sodium andchloride. At maximal therapeutic dosage, Chlorthalidone is approximately equal in itsdiuretic effect to comparable maximal therapeutic doses of benzothiadiazine diuretics.The site of action appears to be the cortical diluting segment of the ascending limb of Henle's loop of the nephron.
Dosage & Administration of Atechlor 100 mg+25 mg
Chlorthalidone is usually given at a dose of 25 mg daily; the usual initial dose of Atenolol is 50 mg daily. Therefore, the initial dose should be one Chlorthalidone 25 & Atenolol 50 mg once a day. If an optimal response is not achieved, the dosage should be increased to one Chlorthalidone 25 & Atenolol 100 mg once a day. Dose of two tablets once daily should not be used as initial therapy in elderly patients.
Dosage of Atechlor 100 mg+25 mg
The initial dose is Atenolol 50 mg and Chlorthalidone 25 mg once a day. If an optimal response is not achieved, another antihypertensive agent may be added gradually beginning with 50 percent of the usual recommended starting dose to avoid an excessive fall in blood pressure. Atenolol is excreted via kidneys and therefore dosage should be adjusted in cases of severe impairment of renal function.Use in elderly: Clinical studies of Atenolol & Chlorthalidone combination did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Interaction of Atechlor 100 mg+25 mg
This combination may potentiate the action of other antihypertensive agents used concominantly. Concominant use with catecholamine depletor (eg, reserpine) may cause hypotension and/or marked bradycardia
Calcium channel blockers, Amiodarone may have an additive effect when given with this combination.
Concomitant use of prostaglandin synthase inhibiting drugs, eg, indomethacin, may decrease the hypotensive effects of beta blockers.
Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Atenolol and Chlorthalidone combination is contraindicated in hypersensitivity to this product or to sulfonamide-derived drugs. It is also contraindicated in patients with sinus bradycardia, heart block greater than first degree, cardiogenic shock, overt cardiac failure and anuria.
Side Effects of Atechlor 100 mg+25 mg
The adverse effects observed for this combination are essentially the same as those seen with the individual components. Atenolol: Bradycardia, Cold Extremities, Postural Hypotension, Leg Pain, Dizziness, Vertigo, Light Headedness, Tiredness, Fatigue, Lethargy, Drowsiness, Depression, Dreaming, Diarrhea, Nausea, Wheeziness, Dyspnea, Chlorthalidone Orthostatic hypotension, anorexia, gastric irritation, vomiting, cramping, constipation, vertigo, purpura, photosensitivity, rash, urticaria, hyperglycemia, glycosuria, hyperuricemia, muscle spasm, weakness, restlessness.
Pregnancy & Lactation
Pregnancy Category D. Atenolol & Chlorthalidone combination can cause fetal harm to the developing baby and may appear in breast milk. So it should not be taken during pregnancy & lactation.
Precautions & Warnings
This combination may aggravate peripheral arterial circulatory disorders. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.
Overdose Effects of Atechlor 100 mg+25 mg
No specific information is available with regard to overdosage of this combination in humans. Treatment should be symptomatic and supportive and directed to the removal of any unabsorbed drug by induced emesis, or administration of activated charcoal. Atenolol can be removed from the general circulation by hemodialysis. Further consideration should be given to dehydration, electrolyte imbalance and hypotension by established procedures.
Store in cool and dry place, protected from light.
Use In Special Populations
Pediatric Uses: Safety and effectiveness in pediatric patients have not been establishedUse in elderly: Clinical studies of Atenolol & Chlorthalidone combination did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Combined antihypertensive preparations
Mode Of Action
Atenolol and chlorthalidone have been used singly and concomitantly for the treatment of hypertension. Studies have shown that there is no interference with bioavailability when these agents are given together in the single combination tablet. Therefore, this combination provides a convenient formulation for the concomitant administration of these two drugs. Atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking agent that provides-
reduction in resting and exercise heart rates and cardiac output
reduction of systolic and diastolic blood pressure at rest and on exercise
reduction in reflex orthostatic tachycardia.
Chlorthalidone is a monosulfonamyl diuretic with prolonged action and low toxicity. It produces diuresis with greatly increased excretion of sodium and chloride at distal convoluted tubule of the nephron.
Pregnancy Category D. Caution should be exercised when this drug is administered to a woman who is breastfeeding.