Bispep87.5 mg/5 ml

Oral Suspension

Bismuth Subsalicylate

Benham Pharmaceuticals Ltd.

Product Code : 2361
MRP 75.00
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Medicine overview

Indications of Bispep 87.5 mg/5 ml

Bispep 87.5 mg/5 ml is indicated for- upset stomach indigestion heartburn nausea and diarrhea.

Theropeutic Class



The demulcent base provides a protective coating of the lower oesophagus and a partial coating in the stomach which holds the Bispep 87.5 mg/5 ml in suspension. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall but also when hydrolysed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal inflammation and hypermotility. In addition, Bispep 87.5 mg/5 mls binds toxins produced by E. coli.

Dosage & Administration of Bispep 87.5 mg/5 ml

Adult: 30 ml 3-4 times daily 30 minutes before meal.Child: 3-12 years: 5-15 ml.

Dosage of Bispep 87.5 mg/5 ml

Adult (>16): 30 ml in dosing cup provided or 6x5 ml spoonfulChildren (10-14 years): 15 mL (3 teaspoons)Children (5-9 years): 7.5 mL (1.5 teaspoons)Children (3-4 years): 5 mL (1 teaspoon)Children under 3 years: Ask a doctor.Use in the elderly: No special precaution is needed. Patient is suffering from renal insufficiency: caution should be taken.Repeat dose every ½ to 1 hour if needed. Not more than 8 doses to be taken in 24 hours.

Interaction of Bispep 87.5 mg/5 ml

Bispep 87.5 mg/5 ml Contains salicylates therefore care should be exercised if receiving drugs to thin the blood (anticoagulant therapy) or oral therapy for diabetes or treatment for gout or arthritis.


Bispep 87.5 mg/5 ml should not be used by patients hypersensitive to Aspirin or other salicylates or any ingredient in this formulation. Keep all medicines out of reach and sight of children.

Side Effects of Bispep 87.5 mg/5 ml

Black stool and black tongue is common with use of Bispep 87.5 mg/5 ml. Bispep 87.5 mg/5 ml should not be used if symptoms are severe or persist for more than 2 days. Do not exceed the recommended dose, shake the bottle before use. For oral use only.

Pregnancy & Lactation

Pregnancy Category-C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Precautions & Warnings

Do not take with aspirin or other salicylates. Caution should be exercised by patients taking medicines for anti-coagulation (thinning of the blood), diabetes or gout.

Overdose Effects of Bispep 87.5 mg/5 ml

Bismuth intoxication may present as an acute encephalopathy with confusion, myoclonic movements, tremor, dysarthria and walking and standing disorders. Bismuth intoxication may also cause gastrointestinal disturbances, skin reactions, discoloration of mucous membranes, and renal dysfunction as a result of acute tubular necrosis. Treatment includes gastric lavage, purgation and hydration. Chelating agents may be effective in the early stages following ingestion and haemodialysis may be necessary. Overdose of Bispep 87.5 mg/5 ml may also give symptoms of salicylate intoxification e.g. dizziness, tinnitus, sweating, nausea, headache. If symptoms occur, use of Bispep 87.5 mg/5 ml  should be discontinued. Management of overdose is the same as that for salicylate overdose.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Mode Of Action

Antacid action: Bispep 87.5 mg/5 ml coats ulcer surface, protecting it from acid and pepsin. It stimulates mucus and bicarbonate secretion and also reacts with HCl, produces bismuth oxychloride and salicylic acid thus reduces HCl.Anti-diarrheal action: It stimulates absorption of water and electrolytes across the intestinal wall. In infectious diarrhea it binds with toxin produced by E.coli, disrupts cell, causing lysis of H.pylori and prevents adhesion of H.pylori in the cell wall of intestine.Anti-inflammatory action: When hydrolyzed to salicylic acid, it inhibits prostaglandin G/H synthase ½. Thus reduces inflammation and Coats the irritated tissue to retard the expulsion of fluid.


There are no adequate data concerning the use of Bispep 87.5 mg/5 ml in pregnant women. Animal studies are insufficient with respect to effects on pregnancy, embryonal/foetal development, parturition and postnatal development. The potential risk for humans is unknown. Bispep 87.5 mg/5 ml should not be used during lactation unless clearly necessary.

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.