Clotison1%+1%

Clotison topical cream is indicated for the short-term treatment of inflamed fungal skin infections in which prompt relief of associated inflammation and itching is desired. Established (label-supported) uses include:

• Dermatophyte (tinea) infections such as tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm) that are associated with significant inflammation or itching
• Cutaneous candidiasis (yeast infections of the skin), including candidal skin-fold (intertriginous) infections
• Candidal nappy (diaper) rash with an inflammatory component

Clotison is intended only for short-term use (typically up to 7 days) to control the inflammatory component of a confirmed or strongly suspected fungal infection. It is not intended as first-line, prolonged, or sole antifungal therapy; once inflammation subsides, treatment is generally continued with a clotrimazole-only preparation to complete full antifungal eradication. It should not be used for infections without a fungal component, and is not appropriate for chronic or long-term management of dermatitis.

Each gram of Clotrimazole + Hydrocortisone cream typically contains Clotrimazole 10 mg (1% w/w) and Hydrocortisone 10 mg (1% w/w) in a water-miscible cream base. Strength and excipients can vary slightly between manufacturers; always check the product label/pack insert of the specific brand dispensed.

Clotison is a fixed-dose topical combination of an imidazole antifungal (clotrimazole) and a mild synthetic corticosteroid (hydrocortisone). It is formulated as a cream for application to the skin, combining an antifungal action against dermatophytes and yeasts with an anti-inflammatory and anti-pruritic action, allowing faster symptomatic relief of itching, redness, and soreness while the antifungal component treats the underlying infection.

Clotison is intended for short-course use under medical guidance and is not a substitute for a confirmed diagnosis; persistent or worsening lesions should be reassessed by a physician.

Clotison belongs to the class of topical antifungal-corticosteroid combinations. Clotrimazole is an imidazole-derivative antifungal agent; hydrocortisone is a low-potency (mild) topical corticosteroid. Together, Clotison is classified for use in inflamed fungal skin infections.

Clotrimazole + Hydrocortisone combines two complementary mechanisms of action:

• Clotrimazole is a broad-spectrum imidazole antifungal that inhibits the fungal enzyme lanosterol 14α-demethylase (a cytochrome P450-dependent enzyme), blocking the conversion of lanosterol to ergosterol. Depletion of ergosterol disrupts fungal cell membrane structure and function, leading to increased membrane permeability and inhibition of fungal growth (fungistatic, and fungicidal at higher concentrations). It is active against dermatophytes (Trichophyton, Microsporum, Epidermophyton species), yeasts (Candida species), and some other fungi.
• Hydrocortisone is a mild-potency corticosteroid that binds intracellular glucocorticoid receptors, inducing anti-inflammatory proteins (e.g., lipocortin-1) and suppressing the release of inflammatory mediators (prostaglandins, leukotrienes, cytokines). This reduces erythema, edema, pruritus, and local inflammatory response.

By combining these actions, Clotrimazole + Hydrocortisone provides both an antifungal effect and rapid symptomatic relief from associated inflammation.

For topical (external) use on the skin only. Clean and dry the affected area, then apply a thin film of Clotison and rub in gently. Avoid contact with the eyes, mouth, and mucous membranes. Do not cover with airtight dressings unless a physician advises otherwise.

Clinically significant systemic drug interactions with topical Clotison are uncommon because systemic absorption from intact skin is minimal when used as directed. However:

• Other topical corticosteroids or antifungals: Concurrent use of other topical corticosteroid-containing products on the same area is not recommended, as it may increase the risk of local and, rarely, systemic corticosteroid side effects.
• Occlusive dressings, other occlusive agents: Using Clotison together with occlusive dressings or on skin fold areas that are naturally occlusive (e.g., under breasts, groin, axillae) increases systemic absorption of hydrocortisone, raising the theoretical risk of systemic corticosteroid effects with extensive or prolonged use.
• Latex products (condoms/diaphragms): The cream base may weaken latex; alternative contraceptive precautions may be advisable if Clotison is used near genital skin.

Inform the prescriber or pharmacist of all other topical or systemic medicines, including other corticosteroids, being used.

Clotison is generally well tolerated when used short-term as directed. Reported adverse effects include:

• Common (local): Mild burning, stinging, itching, or irritation at the application site; skin dryness
• Uncommon: Local erythema, rash, or contact dermatitis; allergic/hypersensitivity skin reactions
• Rare (with prolonged/extensive use, especially under occlusion or in infants/large body-surface-area use): Skin atrophy, striae, telangiectasia, hypopigmentation, or, very rarely, signs of systemic corticosteroid absorption (such as effects on the hypothalamic-pituitary-adrenal axis)
• Rare (allergic): Generalized hypersensitivity reactions including swelling of the face/lips/throat, hives, or difficulty breathing — discontinue immediately and seek urgent medical care if these occur

Pregnancy: Data on the use of Clotison in pregnant women are limited. As a precaution, use during the first trimester should generally be avoided unless considered essential, and Clotison should be used in pregnancy only if clearly needed, at the lowest effective dose for the shortest duration, after consulting a physician who can weigh the potential benefit against any potential risk to the fetus.

Lactation: It is not known whether topically applied clotrimazole or hydrocortisone are excreted in clinically significant amounts in breast milk. As a precaution, avoid applying Clotison directly to the breast/nipple area before breastfeeding, and consult a physician before use while breastfeeding.

The following precautions apply to the use of Clotison:

• For external use only. Avoid contact with the eyes and mucous membranes; not for ophthalmic use.
• Limit duration: Do not use for longer than 7 days without medical reassessment. Prolonged or repeated courses, especially over large body surface areas, on the face, or under occlusion (including infant nappies/diapers, which act as an occlusive dressing), increase the risk of local skin atrophy and systemic corticosteroid absorption.
• Masking of infection: Because hydrocortisone reduces inflammation, it can mask signs of a worsening or untreated infection. If there is no improvement after 2 weeks of appropriate antifungal treatment, or if the condition worsens at any time, stop use and see a physician to reassess the diagnosis.
• Avoid use near the eyes or on skin around the eyes.
• Avoid use on acne, rosacea, or perioral dermatitis, as corticosteroids can worsen these conditions.
• Children: Use in infants and young children only under medical advice; occlusion from diapers/nappies increases absorption risk.
• Immunocompromised patients or those with diabetes should use with additional caution and physician supervision, as corticosteroid effects and infection risk may be altered.

Topical Clotison used as directed carries a low risk of overdose. Accidental ingestion or extensive/prolonged misapplication over large areas may increase absorption of hydrocortisone and, rarely, produce systemic corticosteroid effects. If accidental ingestion occurs, or if excessive application leads to signs such as unusual skin changes, or any systemic symptoms, seek immediate medical attention or contact a poison control center/emergency services. Do not attempt specific home treatment beyond removing residual product from the skin and washing the area with water; management should be guided by a physician.

Store at room temperature (below 30°C), away from light and moisture. Do not freeze. Keep the tube tightly closed and out of reach of children.

Pediatric use: Clotison may be used in children 2 years of age and older for short courses under medical guidance; safety and efficacy in children under 2 years have not been well established, and use in this age group should only occur on a physician's advice due to a higher risk of increased systemic absorption through thinner skin and occlusion from nappies/diapers.

Elderly: No specific dose adjustment is generally required in elderly patients, but skin in this population may be thinner and more prone to atrophy with corticosteroid use; use the shortest effective duration.

Hepatic/renal impairment: Because systemic absorption from topical use is minimal when used as directed, specific dose adjustment is not generally required; however, caution is advised with extensive application or use under occlusion.

Immunocompromised patients: Use with caution and close medical supervision, as fungal infections and corticosteroid effects may behave differently.

Clotison should generally be used for a maximum of 7 consecutive days. If the fungal infection persists after inflammation has resolved, treatment should be continued with a clotrimazole-only preparation (without hydrocortisone) for a further period (commonly up to 2-4 weeks in total, depending on the site and severity) to fully eradicate the fungal infection and reduce the risk of recurrence. If symptoms do not improve within 2 weeks overall, or worsen at any time, a physician should be consulted to confirm the diagnosis.

Topical antifungal-corticosteroid combination (imidazole antifungal + mild corticosteroid)

Clotrimazole + Hydrocortisone acts through two mechanisms: clotrimazole inhibits fungal lanosterol 14α-demethylase, depleting ergosterol and disrupting the fungal cell membrane (antifungal effect), while hydrocortisone binds glucocorticoid receptors to suppress inflammatory mediator release (anti-inflammatory effect), together reducing both the fungal infection and its associated inflammation and itching.

Clotison can be used in children aged 2 years and above for short-term (up to 7 days) treatment of inflamed fungal skin infections, applied thinly twice daily, under a physician's or pharmacist's guidance. Use in infants and children under 2 years is not well established and should only be undertaken on specific medical advice, since nappies/diapers act as an occlusive dressing that increases absorption of the corticosteroid component and raises the risk of local and systemic side effects. Parents/caregivers should avoid prolonged use, avoid tight occlusive clothing over treated areas, and seek medical review if the rash does not improve or worsens.