Corestin5 mg



Unimed Unihealth MFG. Ltd.

Product Code : 4104
MRP 125.00
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Medicine overview

Indications of Corestin 5 mg

Corestin 5 mg is indicated in- Heterozygous Hypercholesterolemia (Familial and Non familial) Homozygous Hypercholesterolemia (Familial) Mixed Dyslipidemia (Fredrickson Type IIa and IIb) Primary prevention of cardiovascular disease

Theropeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins


Corestin 5 mg is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. It produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL. Second, the solution inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles.

Dosage of Corestin 5 mg

Dose range: 5-40 mg once daily. Use 40 mg dose only for patients not reaching LDL-C goal with 20 mgHoFH: Starting dose 20 mg/day.Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 years age, and 5-20 mg/day for patients 10 to 17 years of age.Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 years of age.

Administration of Corestin 5 mg

Corestin 5 mg can be taken with or without food, at any time of day.

Interaction of Corestin 5 mg

Remarkable drug interactions of Corestin 5 mg are:

  • Cyclosporine: Combining these medications increases its exposure. The recommended dose should not exceed 5 mg once daily.
  • Gemfibrosil: It is advisable to avoid combining these drugs. If necessary, limit the dosage to 10 mg once daily when used together.
  • Lopinavir/Ritonavir or atazanavir/ritonavir: When used in combination, these medications can elevate its exposure. The recommended dose should be limited to 10 mg once daily.
  • Coumarin anticoagulants: Combining with coumarin anticoagulants can prolong the international normalized ratio (INR). Achieve a stable INR before initiating treatment and monitor it frequently until it remains stable during therapy.
  • Concomitant lipid-lowering therapies: When used with fibrates and niacin products, there may be an increased risk of skeletal muscle effects.


Corestin 5 mg is contraindicated if- Known hypersensitivity to product components Liver disease, which may include unexplained persistent elevations in hepatic transaminase levels Pregnant women and women who may become pregnant Nursing mothers

Side Effects of Corestin 5 mg

Corestin 5 mg is generally well tolerated. The most frequent adverse events thought to be related to the medicine were headache, myalgia, constipation, asthenia, abdominal pain and nausea.

Pregnancy & Lactation

The safety in pregnant women has not been established. It is not known whether Corestin 5 mg is excreted in human milk or not.

Precautions & Warnings

Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with use of 40 mg dose, advanced age (>65 year), hypothyroidism, renal impairment and combination use with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients should be advised to promptly report unexplained muscle pain, tenderness or weakness. Corestin 5 mg can be discontinued if signs or symptoms appear.Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur. Liver enzymes should be monitored before and during treatment

Storage Conditions

Keep below 30oC temperature, protected from light & moisture. Keep out of the reach of children.

Use In Special Populations

Use in children: The safety and effectiveness in pediatric patients have not been established.


The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.