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Konakion10 mg/ml
Radiant Pharmaceuticals Ltd.
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Medicine overview
Indications of Dinakion 10 mg/ml
Dinakion 10 mg/ml (Vitamin K-1) is indicated in following indications-
Prophylaxis and treatment of haemorrhagic disease in the newborn.
Haemorrhage or risk of haemorrhage as a result of severe hypoprothrombinemia (i.e. deficiency of clotting factors II, VII, IX and X) of various etiologies, including overdosage of courmarin-type anticoagulants, their combination with phenylbutazone, and other forms of hypovitaminosis K (e.g. in obstructive jaundice as well as liver and intestinal disorders, and after prolonged treatment with antibiotics, sulphonamides or salicylates).
Prevention and treatment of bleeding due to vitamin K deficiency.
Theropeutic Class
Vitamin-K Preparations
Pharmacology
Dinakion 10 mg/ml is a procoagulant factor. As a component of a hepatic carboxylase system, Dinakion 10 mg/ml is involved in the post translational carboxylation of clotting factors II (prothrombin), VII, IX and X and the clotting inhibitors protein C and protein S. Dinakion 10 mg/ml is ineffective in hereditary hypoprothrombinemia or hypoprothrombinemia induced by severe hepatic failure. Lack of Dinakion 10 mg/ml leads to an increased tendency to haemorrhagic disease in the newborn. Dinakion 10 mg/ml administration, which promotes synthesis of the above-mentioned coagulation factors by the liver, can reverse an abnormal coagulation status and bleeding due to Dinakion 10 mg/ml deficiency.
Dosage & Administration of Dinakion 10 mg/ml
Prophylaxis: Mild Hemorrhage or hemorrhagic tendency: The usual dose for Neonates is 2 mg orally at or just after birth. Then 2 mg on 4th-5th day and another 2 mg on 28th-30th day orally. If the oral route is unsuitable then 2 mg of drug can be administered by IM or IV route. Children over 1 year of age: Could be given 5-10 mg orally. A single 1 mg (0.1 ml) dose IM is recommended in children who are not assured of receiving a second oral dose or, in the case of breast-fed children, who are not assured of receiving a third oral dose.Therapy: Initially, 1 mg by intravenous injection, with further doses as required, based on the clinical picture and coagulation status. Neonates with special risk factors: Pre-maturity, birth asphyxia (inadequate intake of oxygen by the baby during birth process), obstructive jaundice, inability to swallow, maternal use of anticoagulants or anti-epileptics-
1 mg intramuscularly or intravenously at birth or shortly after birth if the oral route is unsuitable.
Intramuscular and intravenous doses should not exceed 0.4 mg/kg in premature infants weighing less than 2.5 kg.
The size and frequency of further doses should be based on coagulation status
To ensure a total protection of the newborns, 3 prophylactic doses of Vitamin K should be administered orally following the dosing schedule mentioned above.
Interaction of Dinakion 10 mg/ml
Dinakion 10 mg/ml antagonises the effect of coumarin-type anticoagulants. Coadministration of anticonvulsants can impair the action of vitamin K-1.
Contraindications
It is contraindicated in patients with known hypersensitivity to any of its constituents.
Side Effects of Dinakion 10 mg/ml
There are isolated unconfirmed reports on the possible occurrence of anaphylactoid reactions and venous irritation or phlebitis after parenteral use of Dinakion 10 mg/ml injections.
Precautions & Warnings
Careful monitoring of the coagulation parameters is necessary for patients with severely impaired liver function after administration of Dinakion 10 mg/ml .
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Frequently Asked Questions
What is Dinakion 10 mg/ml used for?
Dinakion 10 mg/ml (Vitamin K-1) is indicated in following indications- Prophylaxis and treatment of haemorrhagic disease in the newborn. Haemorrhage or risk of haemorrhage as a result of severe hypoprothrombinemia (i.e. deficiency of clotting factors II, VII, IX and X) of various etiologies, including overdosage of courmarin-type anticoagulants, their combination with phenylbutazone, and other for…
What is the dosage of Dinakion 10 mg/ml?
Prophylaxis: Mild Hemorrhage or hemorrhagic tendency: The usual dose for Neonates is 2 mg orally at or just after birth. Then 2 mg on 4th-5th day and another 2 mg on 28th-30th day orally. If the oral route is unsuitable then 2 mg of drug can be administered by IM or IV route. Children over 1 year of age: Could be given 5-10 mg orally. A single 1 mg (0.1 ml) dose IM is recommended in children who a…
What are the side effects of Dinakion 10 mg/ml?
There are isolated unconfirmed reports on the possible occurrence of anaphylactoid reactions and venous irritation or phlebitis after parenteral use of Dinakion 10 mg/ml injections.
Who should not take Dinakion 10 mg/ml?
It is contraindicated in patients with known hypersensitivity to any of its constituents.
What precautions should be taken with Dinakion 10 mg/ml?
Careful monitoring of the coagulation parameters is necessary for patients with severely impaired liver function after administration of Dinakion 10 mg/ml .
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.