Indications of Dobesil 500 mg
Dobesil 500 mg is indicated for the treatment of hemorrhoidal syndrome, microcirculation disorders of arteovenous origin, clinical signs of chronic venous insufficiency in the lower limbs (pain, cramps, paresthesia, edema, stasis, dermotosis) and in the particular microangiopathy like diabetic retinopathy. It is also indicated in superficial thrombophlebitis as adjuvant therapy.
Calcium dobesilate acts selectively on the capillary walls regulating their physiological functions of resistance and permeability. It lowers blood viscosity and restores normal blood flow. This action is beneficial in all cases of capillary fragility due to metabolic disturbances (constitutional or acquired), and surgical stress or induced by certain medicines.
Dosage & Administration of Dobesil 500 mg
Dobesil 500 mg capsule once or twice daily should be taken with the main meal. Treatment duration, which generally between a few weeks to several months, depends on the disease and its evolution. Dosage should be adapted individually according to the severity of the disease.
Dosage of Dobesil 500 mg
One to two 500 mg capsules daily should be taken with the main meals. Treatment duration, which is generally between a few weeks and several months, depends on the disease and its evolution. Dosage should be adapted individually according to the severity of the case.
Dobesil 500 mg capsule is contraindicated in patients with hypersensitivity to Dobesil 500 mg.Precautions: Dosage should be reduced in case of severe renal insufficiency requiring dialysis. In very rare cases (0.32/million patients), incidence estimated on the basis of spontaneous reports, the intake of Dobesil 500 mg may induce agranulocytosis, probably linked to hyper-sensitivity reaction. This condition may be expressed by symptoms such as high fever, oral cavity infections, (Tonsillitis) sore throat, anogenital inflammation and accompanying symptoms, that are often signs of an infection. The patient should be told that by any sign of infection he/she must immediately inform his/her physician. In that case, it is essential to control without delay the blood formula and leucogram and to discontinue the treatment.
Side Effects of Dobesil 500 mg
Rarely gastrointestinal disorders including nausea and diarrhea, skin reactions, fever, articular pain and in very rare cases, agranulocytosis have been reported. These reactions are generally spontaneously reversible after treatment withdrawal. In case of gastrointestinal disorders, the dosage should be reduced or the treatment temporarily withdrawn. In case of skin reactions, fever, articular pain or change in blood formula, the treatment must be stopped and the treating physician informed as this may constitute allergic reactions.
Pregnancy & Lactation
The safety of Dobesil 500 mg during pregnancy and lactation has not been established. As it is not known whether Dobesil 500 mg crosses the placental barrier in humans, the drug should be administered during pregnancy only if the benefit to the mother outweighs the potential risk to the fetus. Avoid breastfeeding while using this medicine.
Precautions & Warnings
Dosage should be reduced in case of severe renal insufficiency requiring dialysis. In patient with agranulocytosis, this medication can decrease the number of white blood cells which affect the body’s ability to fight against various infections. If patients experience flu-like symptoms such as cough, sore throat, fever and others, they are advised to seek medical care as soon as possible.
Overdose Effects of Dobesil 500 mg
The clinical signs of a possible over dosage are not known.
Store in a cool and dry place, away from light. Keep out of the reach of children.
Mode Of Action
Dobesil 500 mg is a vasoactive drug that presumes effects on endothelial integrity, capillary permeability and blood viscosity. It decreases capillary hyperpermeability, decreases platelet aggregation (clotting- adhesion of platelets) and reduces the serum viscosity, which improves blood circulation and blood supply to tissues and organs.
Studies in pregnant women or animals are not available. As it is not known whether Dobesil 500 mg crosses the placental barrier in humans, the drug should only be administered if it was estimated that the anticipated therapeutic benefit outweigh the potential risk to the fetus. Calcium dobesilate enters the maternal milk in very low quantities (0.µ4g/ml after intake of 3×500mg). As a precaution either the treatment or the breast-feeding should be stopped.