Indications of Duralax 5 mg
Duralax 5 mg is indicated in the-
Treatment of constipation.
Preparation for radiographic or endoscopic examination of the colon.
Duralax 5 mg works by stimulating enteric nerves to cause colonic contractions. It is also a contact laxative; it increases fluid and salt secretion. Action of Duralax 5 mg on small intestine is negligible; stimulant laxatives mainly promote evacuation of the colon.
Dosage & Administration of Duralax 5 mg
Adult: 1-2 tab (5-10 mg) daily, relief in 6-12 hr.
Adult/Pediatric: 1 suppository (10 mg) daily, relief in 15-30 min.
Children <10 yr: 1 tab (5 mg) or 1 suppository (5 mg) daily.
For complete bowel clearance:
>10 yr: 2-4 tab the night before & 1 adult suppository on the day of the procedure.
<10 yr: 1 tab the night before & 1 pediatric suppository on the day of the procedure.
The max daily dose should not be exceeded.
Dosage of Duralax 5 mg
Adult: 5-10 mg at night; occasionally necessary to increase to 15-20 mg;
Child under 10 years: 5 mg.
Before radiological procedures and surgery-
Adult: 10 mg orally at bed-time for 2 days before the examination.
Child: half of the adult dose.
Interaction of Duralax 5 mg
Do not give antacids or milk within 1 hour of taking the drug (enteric coated)
Ileus, intestinal obstruction, acute surgical abdominal conditions such as acute appendicitis, and acute inflammatory bowel diseases, severe dehydration.
Side Effects of Duralax 5 mg
Duralax 5 mg is free of side effects if taken in the recommended doses. Overuse of Duralax 5 mg may result in diarrhea and malabsorption. Duralax 5 mg overuse might be expected to deplete potassium.
Pregnancy & Lactation
Duralax 5 mg has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity or fetotoxicity. No data are available from controlled human pregnancy studies. Duralax 5 mg should only be given during pregnancy when need has been clearly established.It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when HalfLytely and Duralax 5 mg Tablets Bowel Prep Kit is administered to a nursing woman.
Precautions & Warnings
Excessive use of Duralax 5 mg may lead to fluid and electrolyte imbalance. Chronic use can cause dependence.
Overdose Effects of Duralax 5 mg
A laxative is a medicine used to produce bowel movements. Laxative overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.Most laxative overdoses in children are accidental. However, some people regularly take overdoses of laxatives to try to lose weight.
Store in a cool and dry place, protected from light.
Mode Of Action
Duralax 5 mg is a diphenolic compound. Its chemical structure is similar to that of phenolphthalein. It is widely used as a laxative. Duralax 5 mg acts on the colon to stimulate peristalsis and on the small bowel and colon to increase intraluminal water and electrolytes. When applied to the caecum, Duralax 5 mg initiates a response in the entire colon.
Duralax 5 mg like other medicines, should not be used during pregnancy especially the first trimester. In breastfeeding women, Duralax 5 mg should be cautiously used.