G-Calbo500 mg+200 IU

G-Calbo is indicated for the following:

• Prevention and treatment of calcium deficiency in individuals with inadequate dietary calcium intake.
• Adjunct in the management of osteoporosis (postmenopausal, senile, or corticosteroid-induced), used alongside specific anti-osteoporotic therapy (e.g., bisphosphonates) rather than as a standalone treatment.
• Osteomalacia and osteopenia, as calcium and vitamin D3 supplementation to support bone mineralization.
• Supportive therapy in hypoparathyroidism and latent tetany, under physician supervision.
• Increased calcium requirement during pregnancy and lactation, and in the elderly, when dietary intake is insufficient.
• As an adjunct calcium/vitamin D source in rickets in children, under medical supervision.

These are established, guideline-supported uses; G-Calbo is a nutritional supplement and is not a substitute for disease-specific therapy where one is indicated.

Each tablet of Calcium Carbonate [Egg sheel] + Vitamin D3 contains Calcium Carbonate derived from purified eggshell source (equivalent to a specified amount of elemental calcium) and Vitamin D3 (Cholecalciferol). Strength and exact composition vary by manufacturer/brand; refer to the specific product label for exact elemental calcium (mg) and Vitamin D3 (IU) content per tablet.

G-Calbo is a calcium and vitamin D combination supplement in which the calcium carbonate component is sourced from purified, processed eggshell (a naturally occurring, highly bioavailable form of calcium carbonate), combined with vitamin D3 (cholecalciferol) to enhance intestinal calcium absorption.

Calcium is essential for the development and maintenance of healthy bones and teeth, and plays a role in normal muscle contraction, nerve transmission, and blood clotting. When dietary or supplemental calcium intake is inadequate, the body draws calcium from skeletal reserves, which over time can weaken bone structure. Vitamin D3 is required for efficient absorption of calcium from the gastrointestinal tract and for maintaining normal serum calcium and phosphate levels, supporting healthy bone mineralization.

G-Calbo is used as a dietary supplement and adjunct therapy for calcium deficiency states and bone health maintenance.

G-Calbo belongs to the therapeutic class of calcium and vitamin D combination supplements, used as minerals/vitamins for bone health and management of calcium deficiency.

Calcium Carbonate [Egg sheel] + Vitamin D3 combines an elemental calcium source with vitamin D3 to support calcium homeostasis and bone metabolism.

Calcium Carbonate (Eggshell Source)

Calcium carbonate dissociates in the acidic environment of the stomach to release free calcium ions, which are absorbed primarily in the duodenum and proximal jejunum via both active (vitamin D-dependent) and passive transport. Absorbed calcium is used for bone mineralization, neuromuscular function, cardiac function, and coagulation, with excess calcium excreted renally.

Vitamin D3 (Cholecalciferol)

Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D and then in the kidney to the active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol increases intestinal absorption of calcium and phosphate, promotes renal calcium reabsorption, and works with parathyroid hormone to regulate serum calcium concentration and normal bone mineralization.

Together, the components of Calcium Carbonate [Egg sheel] + Vitamin D3 improve net calcium absorption and support skeletal calcium balance more effectively than calcium supplementation alone.

Take G-Calbo orally, preferably with or shortly after meals, with a full glass of water, to enhance absorption and reduce gastrointestinal discomfort. Swallow the tablet whole; do not crush or chew unless the product is specifically formulated as a chewable tablet.

G-Calbo has the following clinically significant interactions:

• Tetracycline and fluoroquinolone antibiotics: Calcium chelates with these antibiotics, reducing their absorption and efficacy. Separate administration by at least 2-3 hours.
• Levothyroxine: Calcium reduces absorption of levothyroxine. Administer at least 4 hours apart.
• Bisphosphonates: Calcium reduces oral bisphosphonate absorption; separate dosing as directed by the physician.
• Digoxin: Hypercalcemia (which can result from excessive calcium/vitamin D intake) increases the risk of digoxin toxicity and cardiac arrhythmia; use with caution and monitor.
• Thiazide diuretics: Concurrent use increases the risk of hypercalcemia due to reduced renal calcium excretion.
• Corticosteroids: May reduce calcium absorption, potentially requiring dose adjustment.

Common side effects of G-Calbo are generally mild and gastrointestinal in nature:

• Constipation
• Bloating and abdominal discomfort
• Nausea
• Mild flatulence

Less common effects, usually associated with excessive or prolonged intake, include:

• Hypercalcemia (symptoms: fatigue, headache, loss of appetite, dry mouth, nausea/vomiting)
• Hypercalciuria and increased risk of kidney stones
• Milk-alkali syndrome (rare, with excessive intake)

G-Calbo is commonly used during pregnancy and lactation to meet increased calcium requirements, but supplementation should be used only under medical supervision and at doses appropriate for the individual, since excessive calcium or vitamin D intake carries risk of maternal hypercalcemia. Use only if clearly needed and as directed by a physician; the potential benefit should justify any potential risk. Vitamin D3 is generally considered compatible with breastfeeding at recommended doses; consult a physician before use.

Use G-Calbo with caution in the following situations:

• History of nephrolithiasis (kidney stones) or renal impairment - monitor renal function and urinary calcium; ensure adequate hydration.
• Sarcoidosis and other granulomatous diseases, or hyperparathyroidism, where vitamin D metabolism may be abnormal, increasing risk of hypercalcemia.
• Egg allergy - given the eggshell source of calcium, patients with known egg or egg-protein allergy should exercise caution and consult a physician before use, although purified eggshell calcium carbonate is largely free of egg protein.
• Concurrent use of digoxin or thiazide diuretics (see Interactions).
• Do not exceed the recommended dose; monitor serum calcium periodically with long-term use, especially in patients at risk of hypercalcemia.

Overdose of G-Calbo may cause hypercalcemia and, with prolonged excessive intake, vitamin D toxicity. Symptoms may include nausea, vomiting, constipation, abdominal pain, excessive thirst, frequent urination, confusion, muscle weakness, and irregular heartbeat. In severe cases, this can progress to renal impairment or cardiac arrhythmia. If overdose is suspected, discontinue the product immediately and seek immediate medical attention or contact a poison control center; do not attempt home treatment.

Store at room temperature (below 30°C), away from light and moisture. Keep out of reach of children.

Pregnant and Lactating Women

Use only under medical supervision to meet increased calcium requirements; avoid exceeding recommended doses (see Pregnancy and Lactation).

Elderly

Commonly used for prevention and management of age-related bone loss; renal function should be monitored, as elderly patients may have reduced ability to excrete excess calcium.

Renal Impairment

Use with caution in mild-to-moderate renal impairment with close monitoring; contraindicated in severe renal impairment (see Contraindications).

Hepatic Impairment

No specific dose adjustment is well established; use with general caution and physician guidance.

Pediatric Use

See Pediatric Uses section.

Duration of G-Calbo therapy depends on the indication and individual calcium/vitamin D status, and is typically determined by the physician - ranging from short-term supplementation during pregnancy/lactation to long-term maintenance therapy in osteoporosis or chronic deficiency states. Periodic monitoring of serum calcium is advised with prolonged use.

Calcium supplement; Vitamin D analogue; Bone health/mineral supplement combination.

Calcium Carbonate [Egg sheel] + Vitamin D3 works through two complementary mechanisms: calcium carbonate dissociates in gastric acid to provide elemental calcium ions that are absorbed in the small intestine and incorporated into bone mineral matrix (hydroxyapatite) and used for neuromuscular and cardiac function; vitamin D3 is converted in the liver and kidney to its active metabolite, calcitriol, which upregulates intestinal calcium-binding proteins to enhance active calcium absorption, promotes renal calcium reabsorption, and facilitates normal bone mineralization, thereby increasing the net utilization of the supplemented calcium.

Use of G-Calbo in children should be under direct physician supervision, individualized by age, body weight, and the degree of calcium/vitamin D deficiency (e.g., in rickets or documented dietary deficiency). Safety and efficacy of specific fixed-dose combination strengths have not been formally established for all pediatric age groups; use the lowest effective dose and monitor for signs of hypercalcemia with prolonged use. Consult a pediatrician before use in infants and young children.