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Havrix720 unit/0.5 ml

IM Injection

Hepatitis A Vaccine

GlaxoSmithKline

Product Code : 8116
MRP 734.50
5% Off
Best PriceTk 697.77
/0.5 ml pre-filled syringe
Out Of Stock
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Medicine overview

Indications of Havrix 720 unit/0.5 ml

Havrix 720 unit/0.5 ml is indicated for active immunization against disease caused by hepatitis A virus (HAV). Havrix 720 unit/0.5 ml is approved for use in persons 12 months of age and older. Primary immunization should be administered at least 2 weeks prior to expected exposure to HAV.

Theropeutic Class

Vaccines, Anti-sera & Immunoglobulin

Pharmacology

The hepatitis A virus belongs to the picornavirus family. It is one of several hepatitis viruses that cause systemic disease with pathology in the liver. The incubation period for hepatitis A averages 28 days (range: 15 to 50 days). The course of hepatitis A infection is extremely variable, ranging from asymptomatic infection to icteric hepatitis and death. The presence of antibodies to HAV confers protection against hepatitis A infection. However, the lowest titer needed to confer protection has not been determined.

Dosage of Havrix 720 unit/0.5 ml

Children and Adolescents: Primary immunization for children and adolescents (12 months through 18 years of age) consists of a single 0.5 mL dose and a 0.5 mL booster dose administered anytime between 6 and 12 months later. The preferred sites for intramuscular injections are the anterolateral aspect of the thigh in young children or the deltoid muscle of the upper arm in older children.Adults: Primary immunization for adults consists of a single 1 mL dose and a 1 mL booster dose administered anytime between 6 and 12 months later. In adults, the injection should be given in the deltoid region.

Administration of Havrix 720 unit/0.5 ml

Preparation For Administration: Shake well before use. With thorough agitation, Havrix 720 unit/0.5 ml is a homogeneous, turbid, white suspension. Do not administer if it appears otherwise. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If either of these conditions exists, the vaccine should not be administered. For the prefilled syringes, attach a sterile needle and administer intramuscularly.For the vials, use a sterile needle and sterile syringe to withdraw the vaccine dose and administer intramuscularly. Changing needles between drawing vaccine from a vial and injecting it into a recipient is not necessary unless the needle has been damaged or contaminated. Use a separate sterile needle and syringe for each individual.Havrix 720 unit/0.5 ml should be administered by intramuscular injection only. Havrix 720 unit/0.5 ml should not be administered in the gluteal region; such injections may result in suboptimal response. Do not administer this product intravenously, intradermally, or subcutaneously.

Interaction of Havrix 720 unit/0.5 ml

Reduced response to vaccination when used concurrently with immunosuppressants such as corticosteroids or antineoplastics.

Contraindications

Hypersensitivity. Vaccines prepared in egg cultures are contraindicated in patients with hypersensitivity reactions to egg. Severe immunodeficiency. Malignant disease being treated with chemotherapy or radiotherapy and for at least 6 mth after stopping treatment. Patients with compromised immune system such as those on high-dose systemic corticosteroids, immunosuppressants or HIV positive.

Side Effects of Havrix 720 unit/0.5 ml

Transient soreness, erythema, induration at inj site. Fever, malaise,

Pregnancy & Lactation

Pregnancy Category C. Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.Nursing Mothers: It is not known whether Havrix 720 unit/0.5 ml is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Havrix 720 unit/0.5 ml is administered to a nursing woman.

Precautions & Warnings

Alcohol or disinfectant used for cleaning the skin prior to inj should be allowed to evaporate completely before vaccination to prevent vaccine inactivation.

Storage Conditions

Store refrigerated between 2° to 8° C . Do not freeze. Discard if the vaccine has been frozen. Do not dilute to administer.

Use In Special Populations

Pediatric Use: The safety and effectiveness of Havrix 720 unit/0.5 ml, doses of 360 EL.U. or 720 EL.U., have been evaluated in more than 22,000 subjects 1 year to 18 years of age. The safety and effectiveness of Havrix 720 unit/0.5 ml have not been established in subjects younger than 12 months of age.Geriatric Use: Clinical studies of Havrix 720 unit/0.5 ml did not include sufficient numbers of subjects 65 years of age and older to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in overall safety between these subjects and younger adult subjects.Hepatic Impairment: Subjects with chronic liver disease had a lower antibody response to Havrix 720 unit/0.5 ml than healthy subjects
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.