Hepaximin200 mg



Aristopharma Ltd.

Product Code : 8184
MRP 220.00
10% Off
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Medicine overview

Indications of Hepaximin 200 mg

Hepaximin 200 mg is indicaed in- Treatment of traveler's diarrhea by noninvasive strains of E. coli reduction in risk of overt hepatic encephalopathy bacterial overgrowth of irritable bowel syndrome.

Theropeutic Class

4-Quinolone preparations


Hepaximin 200 mg is a non-systemic, rifamycin antibiotic which is structural analog of rifampin. Hepaximin 200 mg acts by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase resulting in inhibition of bacterial RNA synthesis.

Dosage & Administration of Hepaximin 200 mg

For traveler's diarrhea (>12 years of age): The recommended dose of Hepaximin 200 mg is 200 mg taken orally three times a day for 3 days. For hepatic encephalopathy (>18 years of age): The recommended dose of Hepaximin 200 mg is 550 mg taken orally two times a day.Hepaximin 200 mg can be administered orally, with or without food.

Dosage of Hepaximin 200 mg

Traveler's Diarrhea: For patients ≥12 years of age: 200 mg 3 times daily for 3 days.Hepatic Encephalopathy: For patients ≥18 years of age: 550 mg 2 times daily.Bacterial overgrowth of irritable bowel syndrome: 400 mg 3 times daily for 10 days or 550 mg 3 times daily for 14 days. Can be taken with or without food

Interaction of Hepaximin 200 mg

In an in vitro study has suggested that Hepaximin 200 mg induces CYP3A4. However, in patients with normal liver function, Hepaximin 200 mg at the recommended dosing regimen is not expected to induce CYP3A4.


Contraindicated in patients with a hypersensitivity to Hepaximin 200 mg or to any of the rifamycin antimicrobial agents, or any components of this product

Side Effects of Hepaximin 200 mg

Side effects include flatulence, headache, abdominal pain, rectal tenesmus, defecation urgency, nausea, constipation, pyrexia, vomiting. Reactions have been reported, including anaphylaxis, angioneurotic edema, and exfoliative dermatitis.

Pregnancy & Lactation

Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. Based on animal data, Hepaximin 200 mg may cause fetal harm. It should be used during pregnancy only if the potential benefit outweighs the probable risk to the fetus. Discontinue nursing or drug, taking into account the importance of the drug to the mother.

Precautions & Warnings

Hepaximin 200 mg is not found to be effective in patients with diarrhea complicated by fever and/or blood in the stools. Hepaximin 200 mg therapy should be discontinued if diarrhea symptoms get worse or persist for more than 24-48 hours and alternative antibiotic therapy should be considered. Pseudomembranous colitis has been reported with nearly all antibacterial agents and may range in severity from mild to life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents.

Overdose Effects of Hepaximin 200 mg

No specific information is available on the treatment of over dosage with Hepaximin 200 mg. In case of over dosage, discontinue Hepaximin 200 mg, treat symptomatically and institute supportive measures as required.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Drug Classes

4-Quinolone preparations

Mode Of Action

Hepaximin 200 mg is a semisynthetic, rifamycin-based non-systemic antibiotic. Very little of the drug will pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. Hepaximin 200 mg inhibits bacterial RNA synthesis by its action on the beta-subunit of the DNA-dependent RNA polymerase. It shows the same broad spectrum activity as rifamycin which exerts bactericidal action against many species of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.


Pregnancy category C. It is not known whether Hepaximin 200 mg is excreted in human milk or not.

Pediatric Uses

Renal Impairment: The pharmacokinetics of Hepaximin 200 mg in patients with impaired renal function has not been studied.Hepatic Impairment: The systemic exposure of Hepaximin 200 mg was markedly elevated in patients with hepatic impairment compared to healthy subjects.

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.