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Ketalar50 mg/ml
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Ketaride50 mg/ml
IM/IV Injection
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Medicine overview
Indications of Ketaride 50 mg/ml
Ketaride 50 mg/ml is recommended for:
As the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. Ketaride 50 mg/ml is best suited for short procedures and it can be used with additional doses, for longer procedures.
For the induction of anesthesia prior to the administration of other general anesthetic agents.
To supplement low-potency agents, such as nitrous oxide.
Theropeutic Class
General (Intravenous) anesthetics
Pharmacology
Ketaride 50 mg/ml is a noncompetitive N-methyl-D-aspartate receptor antagonist that blocks glutamate.
Absorption
It has a direct action on the cortex and limbic system.
Distribution
It produces a cataleptic-like state wherein the patient is withdrawn from the surrounding environment.
Dosage of Ketaride 50 mg/ml
Adult
Dosage:General Anesthesia- IV Induction: 1-4.5 mg/kg single dose IM Induction: 6.5-13mg IV Infusion: 1-2mg/kg at 0.5mg/kg/min Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed
Notes:Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia. Rapid sequence Intubation, Induction - 2mg/kg IVPediatric:General Anesthesia: IV Induction: 1-2 mg/kg IV; range: 4-13 mg/kg IM Induction: 5-10 mg/kg; range: 0.5-4.5 mg/kg Maintenance: 0.01-0.03 mg/kg/min continuous IV infusion Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia
| Condition | Dosage | Notes |
|---|---|---|
| Adult | General Anesthesia- IV Induction: 1-4.5 mg/kg single dose IM Induction: 6.5-13mg IV Infusion: 1-2mg/kg at 0.5mg/kg/min Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed | Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia. Rapid sequence Intubation, Induction - 2mg/kg IVPediatric:General Anesthesia: IV Induction: 1-2 mg/kg IV; range: 4-13 mg/kg IM Induction: 5-10 mg/kg; range: 0.5-4.5 mg/kg Maintenance: 0.01-0.03 mg/kg/min continuous IV infusion Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia |
Administration of Ketaride 50 mg/ml
Rate of Administration: It is recommended that Ketaride 50 mg/ml should be administered slowly (over a period of 60 seconds). More rapid administration may result in respiratory depression and enhanced pressor response.The 100 mg/ml concentration of Ketaride 50 mg/ml should not be injected intravenously without proper dilution. It is recommended the drug be diluted with an equal volume of either Sterile Water for Injection, USP, Normal Saline, or 5% Dextrose in Water.
Interaction of Ketaride 50 mg/ml
Prolonged recovery time with—barbiturates or narcotics
May potentiate neuromuscular blocking—effects of atracurium and tubocurarine including resp depression with apnoea
May increase risk of—bradycardia, hypotension or decreased cardiac output with halogenated anaesthetics
May potentiate CNS depression—and risk of resp depression with CNS depressants (e
phenothiazines, sedating H1-blockers, skeletal muscle relaxants)
May antagonise hypnotic effect—of thiopental
May increase risk of—HTN with thyroid hormones
May increase risk of—hypotension with antihypertensive agents
Reduction in seizure threshold—resulting in unpredictable extensor-type seizures when given concurrently with theophylline
Contraindications
CV disease including severe HTN; patients with increased intraocular or CSF pressure.
Side Effects of Ketaride 50 mg/ml
Common (>1%)
- Emergence reactions (e.g. vivid dreams
- hallucinations
- confusion
- irrational behaviour)
- increased muscle tone sometimes resembling seizures
- temporary HTN and tachycardia
- hypotension
Uncommon
- bradycardia
- arrhythmias
- apnoea
- laryngospasm
- resp depression
- diplopia
- nystagmus
Rare / Long-term
- nausea
- vomiting
- lacrimation
- hypersalivation
- raised intraocular and CSF pressure
- transient rash and pain at inj site
- cystitis.
Pregnancy & Lactation
Pregnancy: The safe use of Ketaride 50 mg/ml in pregnancy has not been established, and such use is not recommended.Lactation: Ketaride 50 mg/ml is likely to be excreted in breast milk and therefore breastfeeding should be discontinued when Ketaride 50 mg/ml is in use.
Precautions & Warnings
Patient with cardiac decompensation, chronic alcoholic or acutely alcohol-intoxicated patients, pre-anaesth elevated CSF pressure, globe injuries, increased intraocular pressure (e.g. glaucoma), neurotic traits or psychiatric illness (e.g. schizophrenia, acute psychosis), acute intermittent porphyria, seizures, hyperthyroidism, pulmonary or upper resp infection, intracranial mass lesions, head injury, or hydrocephalus, hypovolaemia, dehydration, cardiac disease esp coronary artery disease (e.g. CHF, myocardial ischaemia, MI). Pregnancy and lactation.
Overdose Effects of Ketaride 50 mg/ml
Symptoms: Resp depression. Management: Employ supportive ventilation. Mechanical support of respiration is preferred to admin of analeptics.
Storage Conditions
Store between 20-25° C.
Reconstitution
To prepare a dilute solution containing 1 mg of Ketaride 50 mg/ml per ml, aseptically transfer 10 ml (50 mg per ml vial) to 500 ml of Dextrose Injection, 5% or Sodium Chloride Injection, 0.9% and mix well. The resultant solution will contain 1 mg of Ketaride 50 mg/ml per ml.
Frequently Asked Questions
What is Ketaride 50 mg/ml used for?
Ketamine is recommended for: As the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. Ketamine is best suited for short procedures and it can be used with additional doses, for longer procedures. For the induction of anesthesia prior to the administration of other general anesthetic agents. To supplement low-potency agents, such as nitrous…
What is the dosage of Ketaride 50 mg/ml?
Adult:General Anesthesia- IV Induction: 1-4.5 mg/kg single dose IM Induction: 6.5-13mg IV Infusion: 1-2mg/kg at 0.5mg/kg/min Maintenance: The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.Rapid sequence Intubat…
What are the side effects of Ketaride 50 mg/ml?
Emergence reactions (e.g. vivid dreams, hallucinations, confusion, irrational behaviour); increased muscle tone sometimes resembling seizures; temporary HTN and tachycardia, hypotension, bradycardia, arrhythmias, apnoea, laryngospasm, resp depression, diplopia, nystagmus, nausea, vomiting, lacrimation, hypersalivation, raised intraocular and CSF pressure, transient rash and pain at inj site, cysti…
Who should not take Ketaride 50 mg/ml?
CV disease including severe HTN; patients with increased intraocular or CSF pressure.
What precautions should be taken with Ketaride 50 mg/ml?
Patient with cardiac decompensation, chronic alcoholic or acutely alcohol-intoxicated patients, pre-anaesth elevated CSF pressure, globe injuries, increased intraocular pressure (e.g. glaucoma), neurotic traits or psychiatric illness (e.g. schizophrenia, acute psychosis), acute intermittent porphyria, seizures, hyperthyroidism, pulmonary or upper resp infection, intracranial mass lesions, head inj…
Is Ketaride 50 mg/ml safe during pregnancy and breastfeeding?
Pregnancy: The safe use of ketamine in pregnancy has not been established, and such use is not recommended.Lactation: Ketamine is likely to be excreted in breast milk and therefore breastfeeding should be discontinued when ketamine is in use.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.