Laxenna

Laxenna12 mg

Tablet

Sennosides

GlaxoSmithKline

Product Code : 9295
MRP 1.25
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Medicine overview

Indications of Laxenna 12 mg

It is used to treat hard stools (constipation).

Theropeutic Class

Osmotic purgatives

Pharmacology

Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil.Laxenna 12 mg A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified Laxenna 12 mg (Laxenna 12 mg A and B) are used similarly to senna.

Dosage & Administration of Laxenna 12 mg

Constipation Adult: 15-30 mg (as total Laxenna 12 mg) 1-2 times daily. Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime. Bowel evacuation Adult: 105-157.5 mg of Laxenna 12 mg on the day before the procedure. May be given as a liquid preparation.

Dosage of Laxenna 12 mg

Constipation Adult: 15-30 mg (as total Laxenna 12 mg) 1-2 times daily. Child: 2-6 yr: 3.75-7.5 mg once daily in the morning; 6-12 yr: 7.5-15 mg once daily at night or in the morning; ≥12 yr: 15-30 mg at bedtime. Bowel evacuation Adult: 105-157.5 mg of Laxenna 12 mg on the day before the procedure. May be given as a liquid preparation.

Contraindications

Nausea or vomiting, undiagnosed abdominal pain, intestinal obstruction.

Side Effects of Laxenna 12 mg

Mild abdominal discomfort e.g. colic and cramps; diarrhoea, hypokalaemia and atonic non-functioning colon (prolonged use); reversible melanosis coli (chronic use). May colour the urine yellowish-brown at acidic pH or red at alkaline pH.

Pregnancy & Lactation

Laxenna 12 mg has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Laxenna 12 mg should only be given during pregnancy when benefits outweigh risks.Laxenna 12 mg is not excreted into human milk. However, Laxenna 12 mg is a prodrug which is metabolized in vivo to the active Laxenna 12 mg (glucosides of rhein). Rhein is excreted into human milk in very small amounts. No adverse effects have been observed in nursing infants. The American Academy of Pediatrics considers Laxenna 12 mg to be compatible with breast-feeding.

Precautions & Warnings

Inflammatory bowel disease. Avoid prolonged use.

Drug Classes

Osmotic purgatives

Mode Of Action

Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil.Laxenna 12 mg A and B increase intestinal motility through release of active anthraquinones into the colon by colonic bacteria. Purified Laxenna 12 mg (Laxenna 12 mg A and B) are used similarly to senna.

Pregnancy

Laxenna 12 mg has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. Laxenna 12 mg should only be given during pregnancy when benefits outweigh risks.Laxenna 12 mg is not excreted into human milk. However, Laxenna 12 mg is a prodrug which is metabolized in vivo to the active Laxenna 12 mg (glucosides of rhein). Rhein is excreted into human milk in very small amounts. No adverse effects have been observed in nursing infants. The American Academy of Pediatrics considers Laxenna 12 mg to be compatible with breast-feeding.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.