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LNC10 mg
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Medicine overview
Indications of LNC 10 mg
LNC 10 mg is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. LNC 10 mg has been increasingly used in patients with chronic kidney diseaseHypertension is the term used to ... Read moreLNC 10 mg is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. LNC 10 mg has been increasingly used in patients with chronic kidney diseaseHypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel
Theropeutic Class
Calcium-channel blockers
Pharmacology
LNC 10 mg is a dihydropyridine calcium-channel blocker.
Absorption
LNC 10 mg binds to the dihydropy-ridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells via this channel, consequently vascular smooth muscle is relaxed, causing vasodilation. LNC 10 mg inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane.
Distribution
The inhibition of Ca2+ influx via N-type voltage dependent calcium channel was observed over a similar range of drug concentrations to those inhibiting L-type voltage dependent Ca2+ channels. Consequently, release of norepinephrine from sympathetic nerve terminals would be inhibited.
Metabolism
LNC 10 mg is considered to suppress the reflex increase in heart rate after blood pressure reduction.
Dosage & Administration of LNC 10 mg
Adults
Dosage:5-10 mg once daily after breakfast
Maximum dose
Dosage:20 mg once daily
Notes:The safety of LNC 10 mg in pediatric patients has not been established
Use in the elderly
Dosage:Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg)
| Condition | Dosage | Notes |
|---|---|---|
| Adults | 5-10 mg once daily after breakfast | |
| Maximum dose | 20 mg once daily | The safety of LNC 10 mg in pediatric patients has not been established |
| Use in the elderly | Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg) |
Dosage of LNC 10 mg
Adults
Dosage:5-10 mg once daily after breakfast
Maximum dose
Dosage:20 mg once daily
Pediatric use
Dosage:The safety of LNC 10 mg in pediatric patients has not been established
Elderly use
Dosage:Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg)
| Condition | Dosage | Notes |
|---|---|---|
| Adults | 5-10 mg once daily after breakfast | |
| Maximum dose | 20 mg once daily | |
| Pediatric use | The safety of LNC 10 mg in pediatric patients has not been established | |
| Elderly use | Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg) |
Interaction of LNC 10 mg
Other anti-hypertensive, antipsychotics that cause hypotension, quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin.
Contraindications
LNC 10 mg is contraindicated in patients with known sensitivity to LNC 10 mg or any of the excipients or patients having cardiogenic shock, recent MI or acute unstable angina and severe aortic stenosis.
Side Effects of LNC 10 mg
The most common side effects of LNC 10 mg are: Dizziness; flushing; headache; hypotension; peripheral oedema; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression.
Pregnancy & Lactation
LNC 10 mg should not be administered in pregnant woman or woman having possibilities of being pregnant. It is also advisable to avoid the administration of LNC 10 mg to nursing mothers. However, if the administration is indispensable, the patient should be instructed to discontinue lactation.
Precautions & Warnings
LNC 10 mg should be administered with care in the following patients: patients with serious hepatic dysfunction, patients with a history of serious adverse reactions to calcium antagonists. During the discontinuation, the dosage should be gradually decreased under close observation.
Storage Conditions
Store below 30°C, protected from light and moisture. Keep away from reach out of the children.
Drug Classes
Calcium-channel blockers
Mode Of Action
LNC 10 mg is a dihydropyridine calcium-channel blocker. LNC 10 mg binds to the dihydropy-ridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells via this channel, consequently vascular smooth muscle is relaxed, causing vasodilation. LNC 10 mg inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane. The inhibition of Ca2+ influx via N-type voltage dependent calcium channel was observed over a similar range of drug concentrations to those inhibiting L-type voltage dependent Ca2+ channels. Consequently, release of norepinephrine from sympathetic nerve terminals would be inhibited. LNC 10 mg is considered to suppress the reflex increase in heart rate after blood pressure reduction.
Pregnancy
LNC 10 mg should not be administered in pregnant woman or woman having possibilities of being pregnant. It is also advisable to avoid the administration of LNC 10 mg to nursing mothers. However, if the administration is indispensable, the patient should be instructed to discontinue lactation.
Frequently Asked Questions
What is LNC 10 mg used for?
Cilnidipine is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cilnidipine has been increasingly used in patients with chronic kidney diseaseHypertension is the term used to ... Read moreCilnidipine is indicated for the management of hypertension for end-organ protection. It is report…
What is the dosage of LNC 10 mg?
Adults: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily. Pediatric use: The safety of Cilnidipine in pediatric patients has not been established.Elderly use: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).
What are the side effects of LNC 10 mg?
The most common side effects of Cilnidipine are: Dizziness; flushing; headache; hypotension; peripheral oedema; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression.
Who should not take LNC 10 mg?
Cilnidipine is contraindicated in patients with known sensitivity to Cilnidipine or any of the excipients or patients having cardiogenic shock, recent MI or acute unstable angina and severe aortic stenosis.
What precautions should be taken with LNC 10 mg?
Cilnidipine should be administered with care in the following patients: patients with serious hepatic dysfunction, patients with a history of serious adverse reactions to calcium antagonists. During the discontinuation, the dosage should be gradually decreased under close observation.
Is LNC 10 mg safe during pregnancy and breastfeeding?
Cilnidipine should not be administered in pregnant woman or woman having possibilities of being pregnant. It is also advisable to avoid the administration of Cilnidipine to nursing mothers. However, if the administration is indispensable, the patient should be instructed to discontinue lactation.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.