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Ocin5 IU/ml
Opsonin Pharma Ltd.
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Oxyton5 IU/ml
IM/IV Injection
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Medicine overview
Indications of Oxyton 5 IU/ml
Oxyton 5 IU/ml is indicated in- Induction of laborstimulation of uterine contractions. Post delivery periodfor the prevention or treatment of secondary haemorrhage and adherent placenta. To stimulate lactationstimulation of uterine contractions. Post delivery periodfor the prevention or treatment of secondary haemorrhage and adherent placenta. To stimulate lactation
Theropeutic Class
Drugs acting on the Uterus
Pharmacology
Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+ dependent phosphorylating enzyme myosin light-chain kinase.
Absorption
Oxyton 5 IU/ml promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin's light chain kinase.
Excretion
Oxyton 5 IU/ml has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.
Dosage & Administration of Oxyton 5 IU/ml
Induction or Stimulation of Labor
Dosage:The standard solution for infusion of Oxyton 5 IU/ml is prepared by adding the contents of one 1ml vial containing 10 units of Oxyton 5 IU/ml to 1000 ml of infusion fluids
Notes:The combined solution containing 10 mU (1mU=0.001U) of Oxyton 5 IU/ml/ml is rotated in the infusion bottle for thorough mixing. The initial dose should be 0.5-1 mU/min (equal to 3-6 ml of the dilute Oxyton 5 IU/ml solution per hour). At 30-60 minutes intervals the dose should be gradually increased in increments of 1-2 mU/min until the desired contraction pattern has been established. Once the desired frequency of contractions has been reached and labor has progressed to 5-6 cm dilation, the dose may be reduced by similar increments. At term, higher infusion rates should be given with great care and rates exceeding 9-10 mU/min are rarely required. Before term, when the sensitivity of the uterus is lower because of a lower concentration of Oxyton 5 IU/ml receptors, a higher infusion rate may be required
Control of Postpartum Uterine Bleeding
Dosage:Intravenous Infusion (Drip Method): To control postpartum bleeding, 10 to 40 units of Oxyton 5 IU/ml may be added to the bottle, depending on the amount of infusion fluids solution remaining (maximum 40 units to 1000 ml)
Notes:Adjust infusion rate to sustain uterine contraction and control uterine atony
Intramuscular Administration
Dosage:1 mL (10 units) of Oxyton 5 IU/ml can be given after the delivery of the placenta
Treatment of Incomplete or Inevitable Abortion
Dosage:Intravenous infusion of 10 units of Oxyton 5 IU/ml added to 500 ml of a 0.9% sodium chloride solution may help the uterus contract after a suction or sharp curettage for an incomplete, inevitable or elective abortion
Notes:Subsequent to intra-amniotic injection of hypertonic saline, prostaglandins, urea etc. , for mid trimester elective abortion, the injection-to-abortion time may be shortened by infusion of Oxyton 5 IU/ml at the rate of 10 to 20 mU (20 to 40 drops) per minute. The total dose should not exceed 30 units in a 12-hour period due to the risk of water intoxication
| Condition | Dosage | Notes |
|---|---|---|
| Induction or Stimulation of Labor | The standard solution for infusion of Oxyton 5 IU/ml is prepared by adding the contents of one 1ml vial containing 10 units of Oxyton 5 IU/ml to 1000 ml of infusion fluids | The combined solution containing 10 mU (1mU=0.001U) of Oxyton 5 IU/ml/ml is rotated in the infusion bottle for thorough mixing. The initial dose should be 0.5-1 mU/min (equal to 3-6 ml of the dilute Oxyton 5 IU/ml solution per hour). At 30-60 minutes intervals the dose should be gradually increased in increments of 1-2 mU/min until the desired contraction pattern has been established. Once the desired frequency of contractions has been reached and labor has progressed to 5-6 cm dilation, the dose may be reduced by similar increments. At term, higher infusion rates should be given with great care and rates exceeding 9-10 mU/min are rarely required. Before term, when the sensitivity of the uterus is lower because of a lower concentration of Oxyton 5 IU/ml receptors, a higher infusion rate may be required |
| Control of Postpartum Uterine Bleeding | Intravenous Infusion (Drip Method): To control postpartum bleeding, 10 to 40 units of Oxyton 5 IU/ml may be added to the bottle, depending on the amount of infusion fluids solution remaining (maximum 40 units to 1000 ml) | Adjust infusion rate to sustain uterine contraction and control uterine atony |
| Intramuscular Administration | 1 mL (10 units) of Oxyton 5 IU/ml can be given after the delivery of the placenta | |
| Treatment of Incomplete or Inevitable Abortion | Intravenous infusion of 10 units of Oxyton 5 IU/ml added to 500 ml of a 0.9% sodium chloride solution may help the uterus contract after a suction or sharp curettage for an incomplete, inevitable or elective abortion | Subsequent to intra-amniotic injection of hypertonic saline, prostaglandins, urea etc. , for mid trimester elective abortion, the injection-to-abortion time may be shortened by infusion of Oxyton 5 IU/ml at the rate of 10 to 20 mU (20 to 40 drops) per minute. The total dose should not exceed 30 units in a 12-hour period due to the risk of water intoxication |
Dosage of Oxyton 5 IU/ml
Induction of labor, stimulation of uterine contractions: Oxyton 5 IU/ml should be given by intravenous infusion under adequate control, 1-5 IU added to 500 ml of infusion fluid. The administration is started at 1 mU (1 mU=0.001 IU) per minute. According to the effect obtained the dosage can be doubled every 30-45 minutes until the uterus threshold has been attained. A further increase will then usually provide optimal activity. The threshold is generally below 10 mU per minute.N.B.: Intramuscular administration of Oxyton 5 IU/ml may lead to an irregular response and symptoms of overdosage. It intramuscular administration is nevertheless unavoidable, dosage should not exceed 0.5-1 IU per injection. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta: Intramuscular injection of 2-5 IU, or as intravenous infusion in an adequate dosage To stimulate lactation, only it advised by the registered Gynaecologist/Physician: Intramuscular injection of 2 IU Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage: Intramuscular injection of 2-5 IU every 30-60 minutes or as intravenous infusion in an adequate dosage
Interaction of Oxyton 5 IU/ml
Severe hypertension has been reported when Oxyton 5 IU/ml was given three to four hours following prophylactic administration of a vasoconstrictor in conjunction with caudal-block anesthesia. Cyclopropane anesthesia may modify Oxyton 5 IU/ml’s cardiovascular effects, so as to produce unexpected results such as hypotension. Maternal sinus bradycardia with abnormal atrioventricular rhythms has also been noted when Oxyton 5 IU/ml was used concomitantly with cyclopropane anesthesia.
Contraindications
Cephalo-pelvic disproportion.
Abnormal position of the child or abnormal position of the skull.
Overdistention of the inferior segment of the uterus.
Severe toxaemia.
Hypertonic uterine dysfunction.
Foetal distress, where delivery is not imminent (uterine contractions may increase hypoxia).
Cord presentation and prolapse.
Total placenta previa.
Vasa praevia.
Side Effects of Oxyton 5 IU/ml
Hypersensitivity to the drug may result in uterine hypertonicity, spasm, titanic contraction or rupture of the uterus.
The possibility of increased blood loss and afbrinigenemia should be kept in mind when administering the drug.
Severe water intoxication with convulsions and coma has occurred.
Oxyton 5 IU/ml may occasionally cause nausea, vomiting, haemorrhage or cardiac arrhythmias, anaphylactic reaction.
Adverse reactions: Exceptionally, symptoms of water intoxication may occur. An increased incidence of icterus neonatorum has been reported after use of Oxyton 5 IU/ml.
Pregnancy & Lactation
Pregnancy category C. It is not known whether Oxyton 5 IU/ml is excreted in human milk
Precautions & Warnings
Since uterine sensitivity to Oxyton 5 IU/ml may vary widely. Oxyton 5 IU/ml should be used with care. The smallest effective dose must be determined for each patient and then utilized to initiate labor.
Oxyton 5 IU/ml should only be used when adequate medical supervision is provided. Fetal heart rate and maternal blood pressure should be determined.
Oxyton 5 IU/ml should be used with care if scars of the uterus and of the cervix uteri exist.
Overdose Effects of Oxyton 5 IU/ml
Excess Oxyton 5 IU/ml may cause violent uterine contractions leading to fetal bradycardia and arrhythmias, extensive laceration of the soft tissues, uterine rupture and perhaps fetal or maternal death. Treatment consists of immediate discontinuation of the infusion and induction of tocolysis.
Storage Conditions
Store in between 2 to 8°C, in dark & frost free place. Keep out of the reach of children.
Reconstitution
Infusion Fluids-
0.9% Sodium Chloride solution
5% Dextrose-in-water solution
Ringer’s solution
Hartmann’s solution (Ringer-lactate)
Drug Classes
Drugs acting on the Uterus
Mode Of Action
Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+ dependent phosphorylating enzyme myosin light-chain kinase. Oxyton 5 IU/ml promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin's light chain kinase. Oxyton 5 IU/ml has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.
Pregnancy
Pregnancy category C. It is not known whether Oxyton 5 IU/ml is excreted in human milk
Frequently Asked Questions
What is Oxyton 5 IU/ml used for?
Oxytocin is indicated in- Induction of labor, stimulation of uterine contractions. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta. To stimulate lactation, only it advised by the registered Gynaecologist/Physician. ... Read moreOxytocin is indicated in- Induction of labor, stimulation of uterine contractions. Post delivery period, for the preven…
What is the dosage of Oxyton 5 IU/ml?
Induction of labor, stimulation of uterine contractions: Oxytocin should be given by intravenous infusion under adequate control, 1-5 IU added to 500 ml of infusion fluid. The administration is started at 1 mU (1 mU=0.001 IU) per minute. According to the effect obtained the dosage can be doubled every 30-45 minutes until the uterus threshold has been attained. A further increase will then usually …
What are the side effects of Oxyton 5 IU/ml?
Hypersensitivity to the drug may result in uterine hypertonicity, spasm, titanic contraction or rupture of the uterus. The possibility of increased blood loss and afbrinigenemia should be kept in mind when administering the drug. Severe water intoxication with convulsions and coma has occurred. Oxytocin may occasionally cause nausea, vomiting, haemorrhage or cardiac arrhythmias, anaphylactic react…
Who should not take Oxyton 5 IU/ml?
Cephalo-pelvic disproportion. Abnormal position of the child or abnormal position of the skull. Overdistention of the inferior segment of the uterus. Severe toxaemia. Hypertonic uterine dysfunction. Foetal distress, where delivery is not imminent (uterine contractions may increase hypoxia). Cord presentation and prolapse. Total placenta previa. Vasa praevia.
What precautions should be taken with Oxyton 5 IU/ml?
Since uterine sensitivity to oxytocin may vary widely. Oxytocin should be used with care. The smallest effective dose must be determined for each patient and then utilized to initiate labor. Oxytocin should only be used when adequate medical supervision is provided. Fetal heart rate and maternal blood pressure should be determined. Oxytocin should be used with care if scars of the uterus and of th…
Is Oxyton 5 IU/ml safe during pregnancy and breastfeeding?
Pregnancy category C. It is not known whether Oxytocin is excreted in human milk
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.