Oxyton DS10 IU/ml

Oxyton DS 10 IU/ml is indicated in- Induction of labor, stimulation of uterine contractions. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta. To stimulate lactation, only it advised by the registered Gynaecologist/Physician. ... Read moreOxyton DS 10 IU/ml is indicated in- Induction of labor, stimulation of uterine contractions. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta. To stimulate lactation, only it advised by the registered Gynaecologist/Physician. Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage.

Drugs acting on the Uterus

Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+ dependent phosphorylating enzyme myosin light-chain kinase. Oxyton DS 10 IU/ml promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin's light chain kinase. Oxyton DS 10 IU/ml has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Induction or Stimulation of Labor: The standard solution for infusion of Oxyton DS 10 IU/ml is prepared by adding the contents of one 1ml vial containing 10 units of Oxyton DS 10 IU/ml to 1000 ml of infusion fluids. The combined solution containing 10 mU (1mU=0.001U) of Oxyton DS 10 IU/ml/ml is rotated in the infusion bottle for thorough mixing. The initial dose should be 0.5-1 mU/min (equal to 3-6 ml of the dilute Oxyton DS 10 IU/ml solution per hour). At 30-60 minutes intervals the dose should be gradually increased in increments of 1-2 mU/min until the desired contraction pattern has been established. Once the desired frequency of contractions has been reached and labor has progressed to 5-6 cm dilation, the dose may be reduced by similar increments. At term, higher infusion rates should be given with great care and rates exceeding 9-10 mU/min are rarely required. Before term, when the sensitivity of the uterus is lower because of a lower concentration of Oxyton DS 10 IU/ml receptors, a higher infusion rate may be required. Control of Postpartum Uterine Bleeding: Intravenous Infusion (Drip Method): To control postpartum bleeding, 10 to 40 units of Oxyton DS 10 IU/ml may be added to the bottle, depending on the amount of infusion fluids solution remaining (maximum 40 units to 1000 ml). Adjust infusion rate to sustain uterine contraction and control uterine atony. Intramuscular Administration: 1 mL (10 units) of Oxyton DS 10 IU/ml can be given after the delivery of the placenta. Treatment of Incomplete or Inevitable Abortion: Intravenous infusion of 10 units of Oxyton DS 10 IU/ml added to 500 ml of a 0.9% sodium chloride solution may help the uterus contract after a suction or sharp curettage for an incomplete, inevitable or elective abortion. Subsequent to intra-amniotic injection of hypertonic saline, prostaglandins, urea etc., for mid trimester elective abortion, the injection-to-abortion time may be shortened by infusion of Oxyton DS 10 IU/ml at the rate of 10 to 20 mU (20 to 40 drops) per minute. The total dose should not exceed 30 units in a 12-hour period due to the risk of water intoxication.

Induction of labor, stimulation of uterine contractions: Oxyton DS 10 IU/ml should be given by intravenous infusion under adequate control, 1-5 IU added to 500 ml of infusion fluid. The administration is started at 1 mU (1 mU=0.001 IU) per minute. According to the effect obtained the dosage can be doubled every 30-45 minutes until the uterus threshold has been attained. A further increase will then usually provide optimal activity. The threshold is generally below 10 mU per minute.N.B.: Intramuscular administration of Oxyton DS 10 IU/ml may lead to an irregular response and symptoms of overdosage. It intramuscular administration is nevertheless unavoidable, dosage should not exceed 0.5-1 IU per injection. Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta: Intramuscular injection of 2-5 IU, or as intravenous infusion in an adequate dosage To stimulate lactation, only it advised by the registered Gynaecologist/Physician: Intramuscular injection of 2 IU Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage: Intramuscular injection of 2-5 IU every 30-60 minutes or as intravenous infusion in an adequate dosage

Severe hypertension has been reported when Oxyton DS 10 IU/ml was given three to four hours following prophylactic administration of a vasoconstrictor in conjunction with caudal-block anesthesia. Cyclopropane anesthesia may modify Oxyton DS 10 IU/ml’s cardiovascular effects, so as to produce unexpected results such as hypotension. Maternal sinus bradycardia with abnormal atrioventricular rhythms has also been noted when Oxyton DS 10 IU/ml was used concomitantly with cyclopropane anesthesia.

Cephalo-pelvic disproportion. Abnormal position of the child or abnormal position of the skull. Overdistention of the inferior segment of the uterus. Severe toxaemia. Hypertonic uterine dysfunction. Foetal distress, where delivery is not imminent (uterine contractions may increase hypoxia). Cord presentation and prolapse. Total placenta previa. Vasa praevia.

Hypersensitivity to the drug may result in uterine hypertonicity, spasm, titanic contraction or rupture of the uterus.  The possibility of increased blood loss and afbrinigenemia should be kept in mind when administering the drug. Severe water intoxication with convulsions and coma has occurred.  Oxyton DS 10 IU/ml may occasionally cause nausea, vomiting, haemorrhage or cardiac arrhythmias, anaphylactic reaction. Adverse reactions: Exceptionally, symptoms of water intoxication may occur. An increased incidence of icterus neonatorum has been reported after use of Oxyton DS 10 IU/ml.

Pregnancy category C. It is not known whether Oxyton DS 10 IU/ml is excreted in human milk

Since uterine sensitivity to Oxyton DS 10 IU/ml may vary widely. Oxyton DS 10 IU/ml should be used with care. The smallest effective dose must be determined for each patient and then utilized to initiate labor. Oxyton DS 10 IU/ml should only be used when adequate medical supervision is provided. Fetal heart rate and maternal blood pressure should be determined. Oxyton DS 10 IU/ml should be used with care if scars of the uterus and of the cervix uteri exist.

Excess Oxyton DS 10 IU/ml may cause violent uterine contractions leading to fetal bradycardia and arrhythmias, extensive laceration of the soft tissues, uterine rupture and perhaps fetal or maternal death. Treatment consists of immediate discontinuation of the infusion and induction of tocolysis.

Store in between 2 to 8°C, in dark & frost free place. Keep out of the reach of children.

Infusion Fluids- 0.9% Sodium Chloride solution 5% Dextrose-in-water solution Ringer’s solution Hartmann’s solution (Ringer-lactate)

Drugs acting on the Uterus

Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+ dependent phosphorylating enzyme myosin light-chain kinase. Oxyton DS 10 IU/ml promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin's light chain kinase. Oxyton DS 10 IU/ml has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Pregnancy category C. It is not known whether Oxyton DS 10 IU/ml is excreted in human milk