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Regulose3.35 gm/5 ml
Oral Solution
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Medicine overview
Indications of Regulose 3.35 gm/5 ml
Constipation (Chronic Constipation): In every case of chronic constipationinitial treatment should consist of a diet rich in fiber (vegetablessalads
Theropeutic Class
Osmotic purgatives
Pharmacology
Regulose 3.35 gm/5 ml is a synthetic disaccharide.
Absorption
Regulose 3.35 gm/5 ml is minimally absorbed; therefore, the pharmacokinetics of the absorbed material are not relevant to the principal therapeutic action.
Metabolism
Regulose 3.35 gm/5 ml is metabolized in the colon by the saccharolytic bacteria, producing low molecular weight organic acids (mainly lactic acid), which lowers the pH of the colon contents, promote the retention of water by an osmotic effect; thus increasing peristaltic activity.
Dosage & Administration of Regulose 3.35 gm/5 ml
In constipation ( chronic constipation)
Dosage:Adults: Initially 3-6 tea-spoons daily, In long-term therapy 1½-6 tea-spoons daily Children up to 14 years: Initially 3 tea-spoons daily, In long-term therapy 1-2 tea-spoons daily Infants and toddlers: Initially 1-2 tea-spoons daily, In long-term therapy 1 tea-spoon daily In damaged intestinal flora: Adults: 1-2 tea-spoons daily Children: 1 tea-spoon daily For reduction of blood ammonia level: Hyper-ammoniemia in hepatopathy: a maximum of 18-30 tea-spoons daily
In portal systemic encephalopathy
Dosage:hourly doses of 6-9 tea-spoons of Regulose 3.35 gm/5 ml solution may be used to induce the rapid laxation
Notes:When the laxative effect has been achieved, the dose may then be reduced
| Condition | Dosage | Notes |
|---|---|---|
| In constipation ( chronic constipation) | Adults: Initially 3-6 tea-spoons daily, In long-term therapy 1½-6 tea-spoons daily Children up to 14 years: Initially 3 tea-spoons daily, In long-term therapy 1-2 tea-spoons daily Infants and toddlers: Initially 1-2 tea-spoons daily, In long-term therapy 1 tea-spoon daily In damaged intestinal flora: Adults: 1-2 tea-spoons daily Children: 1 tea-spoon daily For reduction of blood ammonia level: Hyper-ammoniemia in hepatopathy: a maximum of 18-30 tea-spoons daily | |
| In portal systemic encephalopathy | hourly doses of 6-9 tea-spoons of Regulose 3.35 gm/5 ml solution may be used to induce the rapid laxation | When the laxative effect has been achieved, the dose may then be reduced |
Interaction of Regulose 3.35 gm/5 ml
There is no significant drug interactions with Regulose 3.35 gm/5 ml. The glycosidic effect of cardiac glycosides can be intensified by potassium deficiency in abuse.
Contraindications
Hypersensitivity to either galactose and or lactose; galactose-free diet, gastro-cardial symptom complex, suspected intestinal obstruction.
Side Effects of Regulose 3.35 gm/5 ml
Occasionally flatulence, cramp and abdominal discomfort can occur at the beginning of treatment; this is rapidly eliminated by reducing the dose. Overdose can result in diarrhoea. In abuse, loss of electrolytes (primarily potassium).
Pregnancy & Lactation
US FDA Pregnancy Category of Regulose 3.35 gm/5 ml is B. Studies show that Regulose 3.35 gm/5 ml has no adverse effects. Decisions regarding use during pregnancy and lactation must be made by registered physician.
Precautions & Warnings
Regulose 3.35 gm/5 ml should be administered with care to patients who are intolerant to Regulose 3.35 gm/5 ml. The dose used in the treatment of (pre) coma hepaticum is usually much higher and may need to be taken into consideration for diabetics.
Overdose Effects of Regulose 3.35 gm/5 ml
There have been no reports of accidental overdosage. In the event of acute overdosage it is expected that diarrhoea and abdominal cramps would be the major symptoms.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Frequently Asked Questions
What is Regulose 3.35 gm/5 ml used for?
Constipation (Chronic Constipation): In every case of chronic constipation, initial treatment should consist of a diet rich in fiber (vegetables, salads, fruits etc.) a generous amount of liquids and much physical exercise. Lactulose is only to be taken when these measures prove insufficient.... Read more
What is the dosage of Regulose 3.35 gm/5 ml?
In constipation ( chronic constipation): Adults: Initially 3-6 tea-spoons daily, In long-term therapy 1½-6 tea-spoons daily Children up to 14 years: Initially 3 tea-spoons daily, In long-term therapy 1-2 tea-spoons daily Infants and toddlers: Initially 1-2 tea-spoons daily, In long-term therapy 1 tea-spoon daily In damaged intestinal flora: Adults: 1-2 tea-spoons daily Children: 1 tea-spoon daily …
What are the side effects of Regulose 3.35 gm/5 ml?
Occasionally flatulence, cramp and abdominal discomfort can occur at the beginning of treatment; this is rapidly eliminated by reducing the dose. Overdose can result in diarrhoea. In abuse, loss of electrolytes (primarily potassium).
Who should not take Regulose 3.35 gm/5 ml?
Hypersensitivity to either galactose and or lactose; galactose-free diet, gastro-cardial symptom complex, suspected intestinal obstruction.
What precautions should be taken with Regulose 3.35 gm/5 ml?
Lactulose should be administered with care to patients who are intolerant to lactulose. The dose used in the treatment of (pre) coma hepaticum is usually much higher and may need to be taken into consideration for diabetics.
Is Regulose 3.35 gm/5 ml safe during pregnancy and breastfeeding?
US FDA Pregnancy Category of Lactulose is B. Studies show that Lactulose has no adverse effects. Decisions regarding use during pregnancy and lactation must be made by registered physician.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.