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Slipam

Slipam30 mg

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Medicine overview

Indications of Slipam 30 mg

Slipam 30 mg is indicated in the following conditions- Insomnia is characterized by difficulty in falling asleep, frequent nocturnal awakenings or early morning awakenings Recurring insomnia or poor sleeping habits In acute or chronic medical situations requiring restful sleep.

Theropeutic Class

Benzodiazepine hypnotics

Pharmacology

Slipam 30 mg is a long-acting benzodiazepine which binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS, including the limbic system, reticular formation.

Absorption

It enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to Cl ions, thus resulting in hyperpolarisation and stabilisation.

Dosage & Administration of Slipam 30 mg

Oral-Short-term management of insomnia Adult
Dosage:15-30 mg at night
Child
Dosage:≥15 yr 15 mg at night
Elderly
Dosage:Max: 15 mg at night
Notes:May be taken with or without food

Dosage of Slipam 30 mg

Adult
Dosage:Usual dosage is 30 mg at bedtime
Notes:In some patients, 15 mg may sufficient
Elderly or debilitated
Dosage:15 mg is usually sufficient for a therapeutic response
Children
Dosage:Not recommended
In hepatic and renal impairment
Dosage:Dosage may need to be reduced in patients with impaired hepatic or renal function

Interaction of Slipam 30 mg

Slipam 30 mg potentiates other CNS depressants such as alcohol, barbiturates, sedative antidepressants, antihistamines and antipsychotic drugs. Cimetidine moderately prolongs the already long half-life of the active metabolite desalkyl Slipam 30 mg. Antacids may delay the absorption of benzodiazepines.

Contraindications

Patients with known hypersensitivity to benzodiazepines or any other ingredients of the capsule.

Side Effects of Slipam 30 mg

Dizziness, drowsiness, light-headedness, staggering, ataxia have occurred, particularly in elderly or debilitated persons. Severe sedation, lethargy, disorientation and coma have been reported.

Pregnancy & Lactation

Category X: Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Precautions & Warnings

Since the risk of the development of oversedation, dizziness, confusion or ataxia increases substantially with larger doses in elderly and debilitated patients, it is recommended that in such patients the dosage should be limited to 15 mg. The usual precautions are indicated for severely depressed patients or those in whom there is any evidence of latent depression; particularly the recognition that suicidal tendencies may be present and protective measures may be necessary. The usual precautions should be observed in patients with chronic pulmonary insufficiency.

Overdose Effects of Slipam 30 mg

Slipam 30 mg overdosage includes somnolence, confusion and coma. Respiration, pulse and blood pressure should be monitored as in all cases of drug overdosage. General supportive measures should be employed, along with immediate gastric lavage.

Storage Conditions

Capsules should be stored in a dry place at 20°-25°C temperature.

Drug Classes

Benzodiazepine hypnotics

Mode Of Action

Slipam 30 mg, a benzodiazepine derivative, is a hypnotic agent which does not appear to decrease dream time as measured by rapid eye movements (REM). Furthermore, it decreases sleep latency and number of awakenings for a consequent increase in total sleep time. Slipam 30 mg binds to an allosteric site on GABA-A receptors. Binding potentiates the action of GABA on GABA-A receptors by opening the chloride channel within the receptor, causing chloride influx and hyperpolarization.

Pregnancy

Pregnancy category-C. Slipam 30 mg is contraindicated in pregnant women. Lactating mothers should avoid it.

Frequently Asked Questions

What is Slipam 30 mg used for?

Flurazepam is indicated in the following conditions- Insomnia is characterized by difficulty in falling asleep, frequent nocturnal awakenings or early morning awakenings Recurring insomnia or poor sleeping habits In acute or chronic medical situations requiring restful sleep.

What is the dosage of Slipam 30 mg?

Adult: Usual dosage is 30 mg at bedtime. In some patients, 15 mg may sufficient. Elderly or debilitated: 15 mg is usually sufficient for a therapeutic response. Children: Not recommended.In hepatic and renal impairment: Dosage may need to be reduced in patients with impaired hepatic or renal function.

What are the side effects of Slipam 30 mg?

Dizziness, drowsiness, light-headedness, staggering, ataxia have occurred, particularly in elderly or debilitated persons. Severe sedation, lethargy, disorientation and coma have been reported.

Who should not take Slipam 30 mg?

Patients with known hypersensitivity to benzodiazepines or any other ingredients of the capsule.

What precautions should be taken with Slipam 30 mg?

Since the risk of the development of oversedation, dizziness, confusion or ataxia increases substantially with larger doses in elderly and debilitated patients, it is recommended that in such patients the dosage should be limited to 15 mg. The usual precautions are indicated for severely depressed patients or those in whom there is any evidence of latent depression; particularly the recognition th…

Is Slipam 30 mg safe during pregnancy and breastfeeding?

Category X: Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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