Tazoskin20 gm

Tazoskin 20 gm is used to treat plaque psoriasis of the skin. It also works to treat acne on the face.

Topical retinoid and related preparations

Tazoskin 20 gm is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of Tazoskin 20 gm, by rapid deesterification in animals and man. In cell culture and in vitro models of skin, Tazoskin 20 gm suppresses expression of MRP8, a marker of inflammation present in the epidermis of psoriasis patients at high levels. In human keratinocyte cultures, it inhibits cornified envelope formation, whose build-up is an element of the psoriatic scale.

For psoriasis: Tazoskin 20 gm cream should be applied once per day, in the evening, to psoriatic lesions, using enough (2 mg/cm2) to cover only the lesion with a thin film. If a bath or shower is taken prior to application, the skin should be dried before applying the cream. If emollients are used, they should be applied at least one hour before application of Tazoskin 20 gm cream.For acne: Cleanse the face gently. After the skin is dry, apply a thin layer (2mg/cm2) of Tazoskin 20 gm cream 0.1% once per day, in the evening, to the skin areas where acne lesions appear. Use enough to cover the entire affected area.

For psoriasis: Tazoskin 20 gm cream should be applied once per day, in the evening, to psoriatic lesions, using enough (2 mg/cm2) to cover only the lesion with a thin film. If a bath or shower is taken prior to application, the skin should be dried before applying the cream. If emollients are used, they should be applied at least one hour before application of Tazoskin 20 gm cream.For acne: Cleanse the face gently. After the skin is dry, apply a thin layer (2mg/cm2) of Tazoskin 20 gm cream 0.1% once per day, in the evening, to the skin areas where acne lesions appear. Use enough to cover the entire affected area.

Concomitant dermatologic medications and cosmetics that have a strong drying effect should be avoided. It is also advisable to "rest" a patient’s skin until the effects of such preparations subside before use of Tazoskin 20 gm cream is begun. Topical steroid may be hazardous in psoriasis; careful patient supervision is important. Consider if infection spreads. Do not use near a naked flame.

Retinoids may cause fetal harm when administered to a pregnant woman. Tazoskin 20 gm cream is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, treatment should be discontinued and the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be warned to the potential risk and use adequate birth-control measures when Tazoskin 20 gm cream is used.

The most frequent adverse events reported with Tazoskin 20 gm cream were limited to the skin. Those occurring in 10 to 23% of patients, in descending order, included pruritus, erythema and burning. For acne treatment, in 10 to 30% patients, it is reported desquamation, dry skin, face pain, irritation and stinging sensation.

Pregnancy: Tazoskin 20 gm is not recommended during pregnancy. It has been shown to cause serious birth defects and problems in animals. Be sure you have discussed this with your doctor.Nursing Mothers: It is not known whether Tazoskin 20 gm passes into breast milk. However, Tazoskin 20 gm is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.

Tazoskin 20 gm cream should be applied only to the affected areas. For external use only. Avoid contact with eyes, eyelids and mouth. If contact with eyes occurs, rinse thoroughly with water. Retinoids should not be used on eczematous skin, as they may cause severe irritation. Patients must be warned to use sunscreens and protective clothing when using Tazoskin 20 gm cream. Some individuals may experience excessive pruritus, burning, skin redness or peeling. If these effects occur, the medication should either be discontinued until the integrity of the skin is restored, or the dosing should be reduced

Excessive topical use cause marked redness, peeling or discomfort. Accidental oral ingestion produces similar adverse effects as those associated with excessive oral intake of Vitamin A or other retinoids. Monitor and take supportive measures as necessary.

Store at 25° C.

Pediatric Use: Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of Tazoskin 20 gm in children up to 12 years of age (gel) and up to 18 years of age (cream) with use in other age groups.Elderly Use (Over 65 year): There is no specific information comparing the use of Tazoskin 20 gm in the elderly with use in other age groups.

Topical retinoid and related preparations

Tazoskin 20 gm is a retinoid prodrug which is converted to its active form, the cognate carboxylic acid of Tazoskin 20 gm, by rapid deesterification in animals and man. In cell culture and in vitro models of skin, Tazoskin 20 gm suppresses expression of MRP8, a marker of inflammation present in the epidermis of psoriasis patients at high levels. In human keratinocyte cultures, it inhibits cornified envelope formation, whose build-up is an element of the psoriatic scale.

Pregnancy: Tazoskin 20 gm is not recommended during pregnancy. It has been shown to cause serious birth defects and problems in animals. Be sure you have discussed this with your doctor.Nursing Mothers: It is not known whether Tazoskin 20 gm passes into breast milk. However, Tazoskin 20 gm is not recommended during breast-feeding because it may cause unwanted effects in nursing babies.

Pediatric Use: Studies of this medicine have been done only in adult patients, and there is no specific information comparing use of Tazoskin 20 gm in children up to 12 years of age (gel) and up to 18 years of age (cream) with use in other age groups.Elderly Use (Over 65 year): There is no specific information comparing the use of Tazoskin 20 gm in the elderly with use in other age groups.