Troniz500 mg

Troniz 500 mg is indicated for Amoebiasis (Intestinal and hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections

Amoebicides, Anti-diarrhoeal Antiprotozoal

Troniz 500 mg is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

Amoebiasis: Adults: 500 mg twice a day for 5 days. Children: 10-25 mg per kg body weight in two divided doses. Amoebic dysentery: Adults: 1.5 gm once a day for 3 days. Children: 40 mg per kg body weight, once a day for 3 days. Giardiasis: Adults: 1.5 gm once daily for 1-2 days. Children: 40 mg per kg body weight for 2 days. Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time.Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.

Amoebiasis: Adults: 500 mg twice a day for 5 days. Children: 10-25 mg per kg body weight in two divided doses. Amoebic dysentery: Adults: 1.5 gm once a day for 3 days. Children: 40 mg per kg body weight, once a day for 3 days. Giardiasis: Adults: 1.5 gm once daily for 1-2 days. Children: 40 mg per kg body weight for 2 days. Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time.Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.

Like other imidazoles, Troniz 500 mg has a mild potential to cause disulfiramlike reactions. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Troniz 500 mg has been reported to decrease the clearance of 5-fluorouracil.

Previous hypersensitivity to Troniz 500 mg and to other nitroimidazoles. Troniz 500 mg is contraindicated in central nervous system disorders, particularly in epilepsy or in peripheral neuropathy.

Side effects of Troniz 500 mg have been mainly limited to the gastrointestinal tract (nausea, vomiting, epigastric pain) and central nervous system (dizziness, headache, lassitude). Unlike other nitroimidazoles, Troniz 500 mg does not interact with alcohol, although this requires further study.Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Troniz 500 mg have mainly included headache, dizziness, lassitude or somnolence, fatigue and weakness. Adverse CNS effects of Troniz 500 mg may be less than that happens with metronidazole. Seizures have not been reported with Troniz 500 mg in studies available to date.

Adequate clinical trials have not been conducted. Troniz 500 mg should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.

In patient with ataxia, vertigo, and mental confusion, Troniz 500 mg should be prescribed with caution. During prolonged treatment with Troniz 500 mg, blood dyscrasia namely mild leukopenia have been reported rarely. In case leukopenia occurs, the decision to discontinue the therapy should depend upon the gravity of infection.

Store at room temperature and protect from light and moisture.

Renal Impairment Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.Hepatic Impairment Severe: Double the interval between doses.

Amoebicides, Anti-diarrhoeal Antiprotozoal

Troniz 500 mg is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

Adequate clinical trials have not been conducted. Troniz 500 mg should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.

Renal Impairment Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.Hepatic Impairment Severe: Double the interval between doses.