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Troniz500 mg
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Medicine overview
Indications of Troniz 500 mg
Troniz 500 mg is indicated for Amoebiasis (Intestinal and hepatic)GiardiasisTrichomoniasisBacterial vaginosisTreatment of susceptible anaerobic infections
Theropeutic Class
Amoebicides, Anti-diarrhoeal Antiprotozoal
Pharmacology
Troniz 500 mg is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria.
Absorption
It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Dosage & Administration of Troniz 500 mg
Amoebiasis
Dosage:Adults: 500 mg twice a day for 5 days
Children
Dosage:10-25 mg per kg body weight in two divided doses
Amoebic dysentery
Dosage:Adults: 1.5 gm once a day for 3 days
Children
Dosage:40 mg per kg body weight, once a day for 3 days
Giardiasis
Dosage:Adults: 1.5 gm once daily for 1-2 days
Children
Dosage:40 mg per kg body weight for 2 days
Trichomoniasis
Dosage:1.5 gm once or 500 mg twice a day for 5 days
Notes:Sexual partner should also be treated at the same time
Bacterial vaginosis
Dosage:3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days
| Condition | Dosage | Notes |
|---|---|---|
| Amoebiasis | Adults: 500 mg twice a day for 5 days | |
| Children | 10-25 mg per kg body weight in two divided doses | |
| Amoebic dysentery | Adults: 1.5 gm once a day for 3 days | |
| Children | 40 mg per kg body weight, once a day for 3 days | |
| Giardiasis | Adults: 1.5 gm once daily for 1-2 days | |
| Children | 40 mg per kg body weight for 2 days | |
| Trichomoniasis | 1.5 gm once or 500 mg twice a day for 5 days | Sexual partner should also be treated at the same time |
| Bacterial vaginosis | 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days |
Dosage of Troniz 500 mg
Amoebiasis
Dosage:Adults: 500 mg twice a day for 5 days
Children
Dosage:10-25 mg per kg body weight in two divided doses
Amoebic dysentery
Dosage:Adults: 1.5 gm once a day for 3 days
Children
Dosage:40 mg per kg body weight, once a day for 3 days
Giardiasis
Dosage:Adults: 1.5 gm once daily for 1-2 days
Children
Dosage:40 mg per kg body weight for 2 days
Trichomoniasis
Dosage:1.5 gm once or 500 mg twice a day for 5 days
Notes:Sexual partner should also be treated at the same time
Bacterial vaginosis
Dosage:3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days
| Condition | Dosage | Notes |
|---|---|---|
| Amoebiasis | Adults: 500 mg twice a day for 5 days | |
| Children | 10-25 mg per kg body weight in two divided doses | |
| Amoebic dysentery | Adults: 1.5 gm once a day for 3 days | |
| Children | 40 mg per kg body weight, once a day for 3 days | |
| Giardiasis | Adults: 1.5 gm once daily for 1-2 days | |
| Children | 40 mg per kg body weight for 2 days | |
| Trichomoniasis | 1.5 gm once or 500 mg twice a day for 5 days | Sexual partner should also be treated at the same time |
| Bacterial vaginosis | 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days |
Interaction of Troniz 500 mg
Like other imidazoles, Troniz 500 mg has a mild potential to cause disulfiramlike reactions. Concomitant administration of oral anticoagulants may increase the risk of haemorrhage due to diminished hepatic metabolism. Troniz 500 mg has been reported to decrease the clearance of 5-fluorouracil.
Contraindications
Previous hypersensitivity to Troniz 500 mg and to other nitroimidazoles. Troniz 500 mg is contraindicated in central nervous system disorders, particularly in epilepsy or in peripheral neuropathy.
Side Effects of Troniz 500 mg
Side effects of Troniz 500 mg have been mainly limited to the gastrointestinal tract (nausea, vomiting, epigastric pain) and central nervous system (dizziness, headache, lassitude). Unlike other nitroimidazoles, Troniz 500 mg does not interact with alcohol, although this requires further study.Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Troniz 500 mg have mainly included headache, dizziness, lassitude or somnolence, fatigue and weakness. Adverse CNS effects of Troniz 500 mg may be less than that happens with metronidazole. Seizures have not been reported with Troniz 500 mg in studies available to date.
Pregnancy & Lactation
Adequate clinical trials have not been conducted. Troniz 500 mg should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.
Precautions & Warnings
In patient with ataxia, vertigo, and mental confusion, Troniz 500 mg should be prescribed with caution. During prolonged treatment with Troniz 500 mg, blood dyscrasia namely mild leukopenia have been reported rarely. In case leukopenia occurs, the decision to discontinue the therapy should depend upon the gravity of infection.
Storage Conditions
Store at room temperature and protect from light and moisture.
Use In Special Populations
Renal Impairment Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.Hepatic Impairment Severe: Double the interval between doses.
Drug Classes
Amoebicides, Anti-diarrhoeal Antiprotozoal
Mode Of Action
Troniz 500 mg is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.
Pregnancy
Adequate clinical trials have not been conducted. Troniz 500 mg should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.
Pediatric Uses
Renal Impairment Haemodialysis patients: Give a supplemental dose (50% of the usual dose) before dialysis.Hepatic Impairment Severe: Double the interval between doses.
Frequently Asked Questions
What is Troniz 500 mg used for?
Ornidazole is indicated for Amoebiasis (Intestinal and hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections
What is the dosage of Troniz 500 mg?
Amoebiasis: Adults: 500 mg twice a day for 5 days. Children: 10-25 mg per kg body weight in two divided doses. Amoebic dysentery: Adults: 1.5 gm once a day for 3 days. Children: 40 mg per kg body weight, once a day for 3 days. Giardiasis: Adults: 1.5 gm once daily for 1-2 days. Children: 40 mg per kg body weight for 2 days. Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partn…
What are the side effects of Troniz 500 mg?
Side effects of Ornidazole have been mainly limited to the gastrointestinal tract (nausea, vomiting, epigastric pain) and central nervous system (dizziness, headache, lassitude). Unlike other nitroimidazoles, Ornidazole does not interact with alcohol, although this requires further study.Leukopenia has been described occasionally during therapy. Adverse central nervous system (CNS) effects of Orni…
Who should not take Troniz 500 mg?
Previous hypersensitivity to Ornidazole and to other nitroimidazoles. Ornidazole is contraindicated in central nervous system disorders, particularly in epilepsy or in peripheral neuropathy.
What precautions should be taken with Troniz 500 mg?
In patient with ataxia, vertigo, and mental confusion, Ornidazole should be prescribed with caution. During prolonged treatment with Ornidazole, blood dyscrasia namely mild leukopenia have been reported rarely. In case leukopenia occurs, the decision to discontinue the therapy should depend upon the gravity of infection.
Is Troniz 500 mg safe during pregnancy and breastfeeding?
Adequate clinical trials have not been conducted. Ornidazole should be prescribed only if the potential benefit justifies the potential risk to fetus/neonate.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.