Caber

Caber0.5 mg

Tablet

Cabergoline

ACI Limited

Product Code : 2618
MRP 80.00
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Medicine overview

Indications of Caber 0.5 mg

It is indicated for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas. It is used to stop breast milk production (lactation) soon after childbirth, stillbirth, abortion or miscarriage. It can also be used to treat other conditions caused by hormonal disturbance ... Read moreIt is indicated for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas. It is used to stop breast milk production (lactation) soon after childbirth, stillbirth, abortion or miscarriage. It can also be used to treat other conditions caused by hormonal disturbance which can result in high levels of prolactin being produced. This includes high levels of prolactin caused by tumours of the pituitary gland in both men and women.

Theropeutic Class

Antiparkinsonian Drug

Pharmacology

Caber 0.5 mg is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. It works by reducing the amount of prolactin that is released from pituitary gland. Results of in vitro studies demonstrate that Caber 0.5 mg exerts a direct inhibitory effect on the secretion of prolactin.

Dosage & Administration of Caber 0.5 mg

The recommended dosage of Caber 0.5 mg Tablet for initiation of therapy is 0.25 mg twice a week. Dosage may be increased by 0.25 mg twice weekly up to a dosage of 1 mg twice a week according to the patient’s serum prolactin level. Before initiating treatment, cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.Dosage increases should not occur more rapidly than every 4 weeks. If the patient does not respond adequately, and no additional benefit is observed with higher doses, the lowest dose that achieved maximal response should be used and other therapeutic approaches considered. Patients receiving long term treatment with Caber 0.5 mg should undergo periodic assessment of their cardiac status and echocardiography should be considered.After a normal serum prolactin level has been maintained for 6 months, Caber 0.5 mg may be discontinued, with periodic monitoring of the serum prolactin level to determine whether or when treatment with Caber 0.5 mg should be reinstituted.To prevent milk production (lactation): 1 mg (two 0.5 mg tablets) on the first day after delivery. To stop lactation once after start of breastfeeding: 0.25 mg (one half of Caber 0.5 mg 0.5 mg table) every 12 hours for two days. To reduce prolactin levels in other conditions: Initially, 0.25 mg twice a week. Dose may be increased up to maximum dose of 4.5 mg or until have responded fully to treatment.

Dosage of Caber 0.5 mg

The recommended dosage of Caber 0.5 mg Tablet for initiation of therapy is 0.25 mg twice a week. Dosage may be increased by 0.25 mg twice weekly up to a dosage of 1 mg twice a week according to the patient’s serum prolactin level. Before initiating treatment, cardiovascular evaluation should be performed and echocardiography should be considered to assess for valvular disease.Dosage increases should not occur more rapidly than every 4 weeks. If the patient does not respond adequately, and no additional benefit is observed with higher doses, the lowest dose that achieved maximal response should be used and other therapeutic approaches considered. Patients receiving long term treatment with Caber 0.5 mg should undergo periodic assessment of their cardiac status and echocardiography should be considered.After a normal serum prolactin level has been maintained for 6 months, Caber 0.5 mg may be discontinued, with periodic monitoring of the serum prolactin level to determine whether or when treatment with Caber 0.5 mg should be reinstituted.To prevent milk production (lactation): 1 mg (two 0.5 mg tablets) on the first day after delivery. To stop lactation once after start of breastfeeding: 0.25 mg (one half of Caber 0.5 mg 0.5 mg table) every 12 hours for two days. To reduce prolactin levels in other conditions: Initially, 0.25 mg twice a week. Dose may be increased up to maximum dose of 4.5 mg or until have responded fully to treatment.

Interaction of Caber 0.5 mg

Caber 0.5 mg should not be administered concurrently with D2-antagonists, such as Phenothiazines, Butyrophenones, Thioxanthenes, or Metoclopramide, Chlorpromazine, Domperidone, and medicines to lower blood pressure.

Contraindications

Caber 0.5 mg tablet is contraindicated in patients with: Uncontrolled hypertension or known hypersensitivity History of cardiac valvular disorders demonstration of valve leaflet thickening High blood pressure in pregnancy associated with swelling and protein in urine History of pulmonary, pericardial, or retroperitoneal fibrotic disorders & serious mental disease.

Side Effects of Caber 0.5 mg

Pathological gambling, increased libido, and hypersexuality have been reported in patients treated with dopamine agonists including Caber 0.5 mg. This has been generally reversible upon reduction of the dose or treatment discontinuation.

Pregnancy & Lactation

Pregnancy category B. It is not known whether this drug is excreted in human milk.

Precautions & Warnings

Initial doses higher than 1.0 mg may produce orthostatic hypotension. Care should be exercised when administering Caber 0.5 mg with other medications known to lower blood pressure, hypersensitivity, severe liver disease & mental illness.

Overdose Effects of Caber 0.5 mg

Over dosage might be expected to produce nasal congestion, syncope, or hallucinations. Measures to support blood pressure should be taken if necessary.

Storage Conditions

Store below 25° C. Keep away from light, moisture & out of reach of children.

Use In Special Populations

Pediatric Use: Safety and effectiveness of Caber 0.5 mg in pediatric patients have not been established.Geriatric Use: In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Use in patients with hepatic impairment: Since Caber 0.5 mg is extensively metabolized by the liver, caution should be used, and careful monitoring exercised, when administering Caber 0.5 mg to patients with hepatic impairment.

Drug Classes

Antiparkinson drugs

Mode Of Action

Caber 0.5 mg is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. It works by reducing the amount of prolactin that is released from pituitary gland. Results of in vitro studies demonstrate that Caber 0.5 mg exerts a direct inhibitory effect on the secretion of prolactin.

Pregnancy

Pregnancy category B. It is not known whether this drug is excreted in human milk.

Pediatric Uses

Pediatric Use: Safety and effectiveness of Caber 0.5 mg in pediatric patients have not been established.Geriatric Use: In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Use in patients with hepatic impairment: Since Caber 0.5 mg is extensively metabolized by the liver, caution should be used, and careful monitoring exercised, when administering Caber 0.5 mg to patients with hepatic impairment.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.