Cardoneb5 mg



Eskayef Bangladesh Ltd.

Product Code : 2888
MRP 10.00
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Medicine overview

Indications of Cardoneb 5 mg

Cardoneb 5 mg is indicated in the treatment of essential hypertension and adjunct in stable mild to moderate heart failure in patients over 70 years.

Theropeutic Class

Beta-adrenoceptor blocking drugs, Beta-blockers


Cardoneb 5 mg is a β-adrenergic receptor blocking agent. Cardoneb 5 mg is a racemate of two enantiomers, d-Cardoneb 5 mg and l-Cardoneb 5 mg. Cardoneb 5 mg exhibits high selectivity for β1-adrenergic receptors and has vasodilating activity due to a direct action on the endothelium, involving nitric oxide release. It lacks intrinsic sympathomimetic and membrane-stabilising activity.

Dosage & Administration of Cardoneb 5 mg

Adults: 5 mg daily, maximum recommended dose 40 mg once daily.Renal Impairment: In patients with severe renal impairment the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed.Hepatic Impairment: In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed.Geriatric Patients: It is not necessary to adjust the dose in the elderly.Pediatric Use: Safety and effectiveness of Cardoneb 5 mg in pediatric patients have not been established.

Interaction of Cardoneb 5 mg

Use caution when Cardoneb 5 mg is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.), Do not use Cardoneb 5 mg with other β-blockers, both digitalis glycosides and β-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia, Cardoneb 5 mg can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (verapamil and diltiazem), or antiarrhythmic agents, such as disopyramide.


Cardoneb 5 mg is contraindicated in the following conditions: severe bradycardia, heart block greater than first degree, patients with cardiogenic shock, decompensated cardiac failure, sick sinus syndrome, patients with severe hepatic impairment, patients who are hypersensitive to any component of this product.

Side Effects of Cardoneb 5 mg

The most common side effects are headache, nausea and bradycardia.

Pregnancy & Lactation

Pregnancy category C and not recommended during nursing.

Precautions & Warnings

Patients with inadequate cardiac function, well-compensated heart failure, myasthenia gravis. Patients undergoing major surgery involving general anaesth. May mask signs and symptoms of hypoglycaemia and hyperthyroidism. Abrupt withdrawal may exacerbate angina symptoms and/or precipitate MI and ventricular arrhythmias in patients with coronary artery disease. Pregnancy and lactation.

Overdose Effects of Cardoneb 5 mg

Symptoms: Bradycardia, hypotension, cardiac failure, dizziness, fatigue, hypoglycaemia, vomiting, bronchospasm, heart block. Management: Symptomatic and supportive treatment. IV atropine may be given for bradycardia, if it persists, admin IV isoproterenol cautiously. For hypotension, admin IV fluids and vasopressors. IV glucagon may also be useful. A β2-agonist and/or aminophylline for bronchospasm. Admin IV glucose for hypoglycaemia and an IV cardiac glycoside and diuretic may be used for CHF.

Storage Conditions

Store between 20-25° C. Protect from light. Keep out of the reach of children.

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.