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Nebicard5 mg
Unimed Unihealth MFG. Ltd.
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Nebita5 mg
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Medicine overview
Indications of Nebita 5 mg
Nebita 5 mg is indicated in the treatment of essential hypertension and adjunct in stable mild to moderate heart failure in patients over 70 years.
Theropeutic Class
Beta-adrenoceptor blocking drugs, Beta-blockers
Pharmacology
Nebita 5 mg is a β-adrenergic receptor blocking agent.
Absorption
Nebita 5 mg is a racemate of two enantiomers, d-Nebita 5 mg and l-Nebita 5 mg.
Distribution
Nebita 5 mg exhibits high selectivity for β1-adrenergic receptors and has vasodilating activity due to a direct action on the endothelium, involving nitric oxide release.
Metabolism
It lacks intrinsic sympathomimetic and membrane-stabilising activity.
Dosage & Administration of Nebita 5 mg
Adults
Dosage:5 mg daily, maximum recommended dose 40 mg once daily
Renal Impairment
Dosage:In patients with severe renal impairment the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed
Hepatic Impairment
Dosage:In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed
Geriatric Patients
Dosage:It is not necessary to adjust the dose in the elderly
Pediatric Use
Dosage:Safety and effectiveness of Nebita 5 mg in pediatric patients have not been established
| Condition | Dosage | Notes |
|---|---|---|
| Adults | 5 mg daily, maximum recommended dose 40 mg once daily | |
| Renal Impairment | In patients with severe renal impairment the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed | |
| Hepatic Impairment | In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed | |
| Geriatric Patients | It is not necessary to adjust the dose in the elderly | |
| Pediatric Use | Safety and effectiveness of Nebita 5 mg in pediatric patients have not been established |
Interaction of Nebita 5 mg
Use caution when Nebita 5 mg is co-administered with CYP2D6 inhibitors (quinidine, propafenone, fluoxetine, paroxetine, etc.), Do not use Nebita 5 mg with other β-blockers, both digitalis glycosides and β-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia, Nebita 5 mg can exacerbate the effects of myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (verapamil and diltiazem), or antiarrhythmic agents, such as disopyramide.
Contraindications
Nebita 5 mg is contraindicated in the following conditions: severe bradycardia, heart block greater than first degree, patients with cardiogenic shock, decompensated cardiac failure, sick sinus syndrome, patients with severe hepatic impairment, patients who are hypersensitive to any component of this product.
Side Effects of Nebita 5 mg
The most common side effects are headache, nausea and bradycardia.
Pregnancy & Lactation
Pregnancy category C and not recommended during nursing.
Precautions & Warnings
Patients with inadequate cardiac function, well-compensated heart failure, myasthenia gravis. Patients undergoing major surgery involving general anaesth. May mask signs and symptoms of hypoglycaemia and hyperthyroidism. Abrupt withdrawal may exacerbate angina symptoms and/or precipitate MI and ventricular arrhythmias in patients with coronary artery disease. Pregnancy and lactation.
Overdose Effects of Nebita 5 mg
Symptoms: Bradycardia, hypotension, cardiac failure, dizziness, fatigue, hypoglycaemia, vomiting, bronchospasm, heart block. Management: Symptomatic and supportive treatment. IV atropine may be given for bradycardia, if it persists, admin IV isoproterenol cautiously. For hypotension, admin IV fluids and vasopressors. IV glucagon may also be useful. A β2-agonist and/or aminophylline for bronchospasm. Admin IV glucose for hypoglycaemia and an IV cardiac glycoside and diuretic may be used for CHF.
Storage Conditions
Store between 20-25° C. Protect from light. Keep out of the reach of children.
Frequently Asked Questions
What is Nebita 5 mg used for?
Nebivolol is indicated in the treatment of essential hypertension and adjunct in stable mild to moderate heart failure in patients over 70 years.
What is the dosage of Nebita 5 mg?
Adults: 5 mg daily, maximum recommended dose 40 mg once daily.Renal Impairment: In patients with severe renal impairment the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed.Hepatic Impairment: In patients with moderate hepatic impairment, the recommended initial dose is 2.5 mg once daily; titrate up slowly if needed.Geriatric Patients: It is not necessary to adjust the d…
What are the side effects of Nebita 5 mg?
The most common side effects are headache, nausea and bradycardia.
Who should not take Nebita 5 mg?
Nebivolol is contraindicated in the following conditions: severe bradycardia, heart block greater than first degree, patients with cardiogenic shock, decompensated cardiac failure, sick sinus syndrome, patients with severe hepatic impairment, patients who are hypersensitive to any component of this product.
What precautions should be taken with Nebita 5 mg?
Patients with inadequate cardiac function, well-compensated heart failure, myasthenia gravis. Patients undergoing major surgery involving general anaesth. May mask signs and symptoms of hypoglycaemia and hyperthyroidism. Abrupt withdrawal may exacerbate angina symptoms and/or precipitate MI and ventricular arrhythmias in patients with coronary artery disease. Pregnancy and lactation.
Is Nebita 5 mg safe during pregnancy and breastfeeding?
Pregnancy category C and not recommended during nursing.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.