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Suzyme325 mg
Square Pharmaceuticals PLC.
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Medicine overview
Indications of Crezyme 325 mg
Crezyme 325 mg is employed for the treatment of patients with
Chronic pancreatitis
Cystic fibrosis/Mucoviscidosis
Following partial or complete pancreatectomy
Total gastrectomy
Steatorrhea
Somatostatinoma
Celiac disease and
Other conditions associated with pancreatic insufficiency
Composition
Each enteric film-coated tablet contains 325 mg of Crezyme 325 mg BP that provides not less than the following enzymatic activity-
Amylase 7800 units
Protease 455 units
Lipase 6500 units
Theropeutic Class
Digestive Enzyme
Pharmacology
Crezyme 325 mg is a preparation of Crezyme 325 mg having protease, lipase and amylase enzyme activity. Crezyme 325 mg hydrolyses fats to glycerol and fatty acids, changes protein into proteoses and derived substances and converts starch into dextrins and sugars. Crezyme 325 mg is employed in the conditions where the secretion of pancreatic juice is defcient.
Dosage & Administration of Crezyme 325 mg
1-3 tablets daily with meal or as per direction of the physician.
Dosage of Crezyme 325 mg
2-3 tablets to be swallowed whole with little water immediately after or during meal. Or as directed by the physician
Interaction of Crezyme 325 mg
Alkaline media will rupture the enteric coating. As such to prevent bursting out of the content in the stomach Crezyme 325 mg should not be used concurrently with antacid.
Contraindications
Crezyme 325 mg is contraindicated in patients with known hypersensitivity to the drug.
Side Effects of Crezyme 325 mg
The most frequent side effects are gastrointestinal including nausea, vomiting and abdominal discomfort. Buccal and perianal soreness may occur, particularly in infants. Hypersensitivity reactions manifested by sneezing, lacrimation or skin rashes have been reported.
Pregnancy & Lactation
Pregnancy category C. Not known whether Crezyme 325 mg is distributed into milk. Caution advised if Crezyme 325 mg is used.
Precautions & Warnings
Patients known to be allergic to animal protein should be treated with caution.
Overdose Effects of Crezyme 325 mg
Excessive dosage may produce a laxative effect. Systemic toxicity does not occur. Very high dosage may cause hyperuricaemia and hyperuricosuria
Storage Conditions
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.
Drug Classes
Digestive Enzyme
Mode Of Action
Crezyme 325 mg is a preparation of Crezyme 325 mg, an extract from mammalian pancreas containing enzymes with Amylase, Protease and Lipase activity. It is designed to disintegrate in the alkaline medium of the duodenum where it releases the active enzyme components of Crezyme 325 mg (Amylase, Protease and Lipase). Amylase hydrolyzes dietary starch to yield maltose, maltoriose and a-dextrin. Protease cleaves peptide bonds in the center of proteins and polypeptides and forms amino acids and oligopeptides. Lipase hydrolyzes dietary triglycerides forming two molecules of fatty acid and a molecule of beta-monoglyceride. It converts not less than 25 times its weight of starch into soluble carbohydrates and not less than 25 times its weight of casein into proteoses within 5 mins, (equivalent to 150 times in 30 mins).
Pregnancy
Crezyme 325 mg should be given to a pregnant woman only if clearly needed. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Crezyme 325 mg is administered to a nursing mother.
Frequently Asked Questions
What is Crezyme 325 mg used for?
Crezyme 325 mg is employed for the treatment of patients with Chronic pancreatitis Cystic fibrosis/Mucoviscidosis Following partial or complete pancreatectomy Total gastrectomy Steatorrhea Somatostatinoma Celiac disease and Other conditions associated with pancreatic insufficiency
What is the dosage of Crezyme 325 mg?
2-3 tablets to be swallowed whole with little water immediately after or during meal. Or as directed by the physician
What are the side effects of Crezyme 325 mg?
The most frequent side effects are gastrointestinal including nausea, vomiting and abdominal discomfort. Buccal and perianal soreness may occur, particularly in infants. Hypersensitivity reactions manifested by sneezing, lacrimation or skin rashes have been reported.
Who should not take Crezyme 325 mg?
Crezyme 325 mg is contraindicated in patients with known hypersensitivity to the drug.
What precautions should be taken with Crezyme 325 mg?
Patients known to be allergic to animal protein should be treated with caution.
Is Crezyme 325 mg safe during pregnancy and breastfeeding?
Pregnancy category C. Not known whether Crezyme 325 mg is distributed into milk. Caution advised if Crezyme 325 mg is used.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.