A-Forte50000 IU

Illness due to vitamin A deficiency in ophthalmology such as night blindness, xerophthalmia and dermatological such as changes in skin, hair and nails. Concomitant therapy of mucosa illnesses such as sinusitis, bronchitis, in acne vulgaris, ichthyosis, Darier's disease, psoriasis etc. To meet vitmin ... Read moreIllness due to vitamin A deficiency in ophthalmology such as night blindness, xerophthalmia and dermatological such as changes in skin, hair and nails. Concomitant therapy of mucosa illnesses such as sinusitis, bronchitis, in acne vulgaris, ichthyosis, Darier's disease, psoriasis etc. To meet vitmin A demand in growth, resistance to infections and night blindness. This is also indicated to meet vitamin A deficiency after diarrhoea and prophylaxis of measles.

Vitamin-A preparations

A-Forte 50000 IU plays an essential role in the function of retina and is essential for growh and differentiation of epithelial tissue.

A-Forte 50000 IU deficiency For severe deficiency with corneal changes: 500,000 unit/day for 3 days, followed by 50,000 unit/day for 2 wk and then 10,000-20,000 unit/day for 2 mth as follow-up therapy.For cases without corneal changes: 10,000-25,000 unit/day until clinical improvement occurs (usually 1 -2 wk).

For Adults: 50000 IU-100000 IU daily up to 200000 IU if necessary.Children (Above 1 year): Night blindness, Bitot's spots, Xerophthalmia: 200000 IU 1st day, 2nd day, 14th day Measles: 200000 IU 1st day, 2nd day Diarrhoea, Respiratory tract infection: 200000 IU every time after disease Severe malnutrition: 200000 IU single-dose or as directed by the registered physician.

Decreased absorption with neomycin. Increased risk of hypervitaminosis A with synthetic retinoids eg, acitretin, isotretinoin and tretinoin. Increased risk of toxicity when used with alcohol.

Hypervitaminosis of vitamin A. Sensitivity to any of the ingredients in this preparation.

A-Forte 50000 IU intoxication includes irritability, vomiting, loss of appetite, headache, dry and pruritic skin, skin desquamation, fatique, pain in ankles and feet, myalgia, loss of body hair, papilledema, nystagmus, liver sclerosis and cirrhosis.

Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

Ensure A-Forte 50000 IU free interval after long term therapy with vitamin A. No daily dose over 5000 IU during pregnancy. A-Forte 50000 IU doses over 50000 IU under medical supervision only.

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.

Vitamin-A preparations

Beta-carotene, retinol, and retinal have effective and reliable vitamin A activity. Retinal and retinol are in chemical equilibrium in the body and have equivalent antixerophthalmic activity. Retinal combines with the rod pigment, opsin, in the retina to form rhodopsin, necessary for visual dark adaptation.A-Forte 50000 IU prevents retardation of growth and preserves the epithe-lial cells' integrity. Normal adult liver storage is sufficient to satisfy two years'requirements of vitamin A. A-Forte 50000 IU is readily absorbed from the gastrointestinal tract, where the biosynthesis of vitamin A from beta-carotene takes place. A-Forte 50000 IU absorption requires bile salts, pancreatic lipase, and dietary fat. It is transported in the blood to the liver by the chy lomicron fraction of the lymph. A-Forte 50000 IUis stored in Kupffer cells of the liver mainly as the palmitate. Normal serum vitamin A is 80-300 Units per 100 mL (plasma range is 30-70 mcg per dl) and for carotenoids 270-753 Units per 100 mL.The normal adult liver contains approximately 100 to 300 micrograms per gram, mostly as retinol palmitate.

Safety of amounts exceeding 6,000 Units of vitamin A daily during pregnancy has not been established at this time. The use of vitamin A in excess of the recommended dietary allowance may cause fetal harm when administered to a pregnant woman. Animal reproduction studies have shown fetal abnormalities associated with over-dosage in several species. Malformations of the central nervous system, the eye, the palate, and the urogenital tract are recorded. A-Forte 50000 IUin excess of the recommended dietary allowance is contraindicated in women who are or may become pregnant. If vitamin Ais used during pregnancy, or if the patient becomes pregnant while taking vitamin A, the patient should be apprised of the potential hazard to the fetus. The U.S. Recommended Daily Allowance (RDA) of vitamin A (5,000 Units) is recommended for nursing mothers.