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Acmecilin250 mg/via
ACME Laboratories Ltd.
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Ampexin250 mg/vial
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Medicine overview
Indications of Ampexin 250 mg/vial
P. mirabilisenterococciShigellaS. typhosa and other Salmonellaand streptococci including streptococcus pneumoniae. Infections of the Gastrointestinal Tract: ShigellaS. typhosa and other SalmonellaE. coliP. mirabilis
Theropeutic Class
Broad spectrum penicillins
Pharmacology
Ampexin 250 mg/vial inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls.
Absorption
Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Dosage of Ampexin 250 mg/vial
Intra-articular
Dosage:Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily
Child
Dosage:<10 yr Half of adult routine dosage
Intraperitoneal
Dosage:Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily
Child
Dosage:<10 yr Half of adult routine dosage
Intrapleural
Dosage:Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily
Child
Dosage:<10 yr Half of adult routine dosage Intravenous:Meningitis- Adult: 2 gm 6 hrly
Child
Dosage:150 mg/kg daily in divided doses
Notes:Intrapartum prophylaxis against group B Streptoccocal infection in neonates- Adult: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery
Oral
Dosage:Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis- Adult: 0.25-1 gm 6 hrly
Child
Dosage:<10 yr Half of adult routine dosage
Typhoid and paratyphoid fever- Adult
Dosage:1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers
Uncomplicated gonorrhoea- Adult
Dosage:2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients
Urinary tract infections- Adult
Dosage:500 mg 8 hrly
Parenteral
Dosage:Susceptible infections- Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion
Child
Dosage:<10 yr Half of adult routine dosage
Septicaemia- Adult
Dosage:150-200 mg/kg daily
Notes:Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after the patient has become asymptomatic or when there is evidence of bacterial eradication. Recommended treatment duration for infections caused by group-A β-haemolytic streptococci: At least 10-days, to prevent occurrence of acute rheumatic fever or acute glomerulonephritis
Child
Dosage:Same as adult dose
| Condition | Dosage | Notes |
|---|---|---|
| Intra-articular | Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily | |
| Child | <10 yr Half of adult routine dosage | |
| Intraperitoneal | Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily | |
| Child | <10 yr Half of adult routine dosage | |
| Intrapleural | Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily | |
| Child | <10 yr Half of adult routine dosage Intravenous:Meningitis- Adult: 2 gm 6 hrly | |
| Child | 150 mg/kg daily in divided doses | Intrapartum prophylaxis against group B Streptoccocal infection in neonates- Adult: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery |
| Oral | Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis- Adult: 0.25-1 gm 6 hrly | |
| Child | <10 yr Half of adult routine dosage | |
| Typhoid and paratyphoid fever- Adult | 1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers | |
| Uncomplicated gonorrhoea- Adult | 2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients | |
| Urinary tract infections- Adult | 500 mg 8 hrly | |
| Parenteral | Susceptible infections- Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion | |
| Child | <10 yr Half of adult routine dosage | |
| Septicaemia- Adult | 150-200 mg/kg daily | Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after the patient has become asymptomatic or when there is evidence of bacterial eradication. Recommended treatment duration for infections caused by group-A β-haemolytic streptococci: At least 10-days, to prevent occurrence of acute rheumatic fever or acute glomerulonephritis |
| Child | Same as adult dose |
Administration of Ampexin 250 mg/vial
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Interaction of Ampexin 250 mg/vial
May reduce the efficacy of oral contraceptives. May alter INR while on warfarin and phenindione. May reduce the efficacy of oral typhoid vaccines. May reduce the excretion of methotrexate. Reduced excretion with probenecid and sulfinpyrazone, resulting to increased risk of toxicity. Allopurinol increases Ampexin 250 mg/vial-induced skin reactions. Reduced absorption with chloroquine. Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline) may interfere with the bactericidal action of Ampexin 250 mg/vial.
Contraindications
Hypersensitivity to Ampexin 250 mg/vial and other penicillins.
Side Effects of Ampexin 250 mg/vial
Nausea, vomiting, diarrhoea, erythematous maculo-papular rashes, sore mouth, black/hairy tongue, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, fever, joint pains, serum sickness-like symptoms, haemolytic anaemia, thrombocytopenia, leucopenia, neutropenia, coagulation disorders, prolonged bleeding time and prothrombin time, CNS toxicity (e.g. convulsions); paraesthesia, nephropathy, interstitial nephritis, hepatitis, cholestatic jaundice, moderate and transient increase in transaminases, Anaphylaxis, Clostridium difficile-associated diarrhoea (CDAD).
Pregnancy & Lactation
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Precautions & Warnings
Patient with history of β-lactam allergy. During renal impairment, Pregnancy and lactation.
Overdose Effects of Ampexin 250 mg/vial
Symptoms: Nausea, vomiting and diarrhoea. Management: Symptomatic and supportive treatment. May be removed from the circulation by haemodialysis.
Storage Conditions
Store between 20-25° C. Reconstituted oral susp: Store between 2-8° C (discard after 14 days).
Use In Special Populations
Renal Impairment: CrCl<10: Dose reduction or increase in dose interval.
Reconstitution
Intramuscular: Add 1.5 mL water for inj to 500 mg vial contents.Intravenous: Dissolve 500 mg in 10 mL water for inj. May be added to infusion fluids or injected, suitably diluted into the drip tube.Intra-articular: Dissolve 500 mg in up to 5 mL of water for inj or sterile procaine HCl 0.5% soln.Intraperitoneal: Dissolve 500 mg in up to 10 mL water for inj.Intrapleural: Dissolve 500 mg in 5-10 mL water for inj.
Frequently Asked Questions
What is Ampexin 250 mg/vial used for?
Ampicillin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below: Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae. Infections of the Respiratory Tract: Nonpenicillinase-producing H. influenzae and staphylo…
What is the dosage of Ampexin 250 mg/vial?
Intra-articular:Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily. Child: <10 yr Half of adult routine dosage. Intraperitoneal:Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily. Child: <10 yr Half of adult routine dosage. Intrapleural:Supplement in systemic therapy for treatment of susceptible infections- Adult: 50…
What are the side effects of Ampexin 250 mg/vial?
Nausea, vomiting, diarrhoea, erythematous maculo-papular rashes, sore mouth, black/hairy tongue, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, fever, joint pains, serum sickness-like symptoms, haemolytic anaemia, thrombocytopenia, leucopenia, neutropenia, coagulation disorders, prolonged bleeding time and prothrombin time, CNS toxicity (e.g. convulsio…
Who should not take Ampexin 250 mg/vial?
Hypersensitivity to ampicillin and other penicillins.
What precautions should be taken with Ampexin 250 mg/vial?
Patient with history of β-lactam allergy. During renal impairment, Pregnancy and lactation.
Is Ampexin 250 mg/vial safe during pregnancy and breastfeeding?
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.