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Anacare1 mg
Tablet
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Medicine overview
Indications of Anacare 1 mg
Anacare 1 mg is indicated in-
Treatment of early breast cancer in hormone receptor positive post-menopausal women.
Adjuvant treatment of early breast cancer in hormone receptor positive
postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen.
Reduction in the incidence of contralateral breast cancers in post menopausal women receiving Anacare 1 mg as adjuvant treatment for early breast cancer.
Treatment of advanced breast cancer in post-menopausal women.
Theropeutic Class
Hormonal Chemotherapy
Pharmacology
The growth of many cancers of the breast is stimulated or maintained by estrogens.
Absorption
Anacare 1 mg is a selective non-steroidal aromatase inhibitor.
Distribution
The suppression of estrogen biosynthesis in peripheral tissues and in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme.
Excretion
In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.
Dosage & Administration of Anacare 1 mg
Adults and elderly
Dosage:1 mg tablet to be taken orally once a day
| Condition | Dosage | Notes |
|---|---|---|
| Adults and elderly | 1 mg tablet to be taken orally once a day |
Dosage of Anacare 1 mg
Adults Including the Elderly
Dosage:One tablet (1 mg) to be taken orally once a day
Children
Dosage:The use of Anacare 1 mg is not recommended in children, as efficacy has not been establishedRenal Impairment: No dose change is recommended
Hepatic Impairment
Dosage:No dose change is recommended
| Condition | Dosage | Notes |
|---|---|---|
| Adults Including the Elderly | One tablet (1 mg) to be taken orally once a day | |
| Children | The use of Anacare 1 mg is not recommended in children, as efficacy has not been establishedRenal Impairment: No dose change is recommended | |
| Hepatic Impairment | No dose change is recommended |
Interaction of Anacare 1 mg
Tamoxifen and/or other therapies containing estrogen should not be co-administered with Anacare 1 mg.
Contraindications
Patients with severe renal impairment (Creatinine clearance less than 20 mL/min), patients with moderate to severe hepatic disease and known hypersensitivity to Anacare 1 mg or to any of the excipients. Oestrozen-containing therapies should not be co-administered with anastrazole as they would negate its pharmacological action.
Side Effects of Anacare 1 mg
Very common side effects: Hot flushes, asthenia, joint stiffness, arthritis, headache, nausea, rash etc. Common side effects: Hair thinning, allergic reactions, diarrhea, vomiting, somnolence etc.
Pregnancy & Lactation
Anacare 1 mg is contraindicated in pregnant and lactating women.
Precautions & Warnings
Anacare 1 mg is not recommended for use in children or in pre-menopausal women as safety and efficacy have not been established in these groups of patients.
Anacare 1 mg has not been investigated in patients with severe hepatic or severe renal impairment. The potential risk/benefit to such patients should be carefully considered before administration of Anacare 1 mg.
As Anacare 1 mg lowers circulating estrogen levels, it may cause a reduction in bone mineral density with a possible consequent increased risk of fracture.
Overdose Effects of Anacare 1 mg
There is limited clinical experience of overdose of Anacare 1 mg. There are no reports where a patient has taken a dose in excess of 60 mg. No toxicity was observed and no clinically relevant adverse effects have been seen.
Storage Conditions
Store in a cool & dry place, protected from light and moisture. Keep out of reach of children.
Use In Special Populations
Renal impairment: No dose change is recommended in patients with mild or moderate renal impairment.Hepatic impairment: No dose change is recommended in patients with mild hepatic impairment. For early disease, the recommended duration of treatment should be 5 years.
Drug Classes
Hormonal Chemotherapy
Mode Of Action
Anastrazole exerts its anti-estrogenic effects via selective and competitive inhibition of the aromatase enzyme found predominantly in the adrenal glands, liver, and fatty tissues. Many breast cancers are hormone receptor-positive, meaning their growth is stimulated and/or maintained by the presence of hormones such as estrogen or progesterone. In postmenopausal women, estrogen is primarily derived from the conversion of adrenally-produced androgens into estrogens by the aromatase enzyme- by competitively inhibiting the biosynthesis of estrogen at these enzymes, Anacare 1 mg effectively suppresses circulating estrogen levels and, subsequently, the growth of hormone receptor-positive tumours.
Pregnancy
Anacare 1 mg must not be administered during pregnancy or lactation.
Frequently Asked Questions
What is Anacare 1 mg used for?
Anastrozole is indicated in- Treatment of early breast cancer in hormone receptor positive post-menopausal women. Adjuvant treatment of early breast cancer in hormone receptor positive postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen. Reduction in the incidence of contralateral breast cancers in post menopausal women receiving Anastrozole as adjuvant treatment for early br…
What is the dosage of Anacare 1 mg?
Adults Including the Elderly: One tablet (1 mg) to be taken orally once a day.Children: The use of Anastrozole is not recommended in children, as efficacy has not been establishedRenal Impairment: No dose change is recommended.Hepatic Impairment: No dose change is recommended.
What are the side effects of Anacare 1 mg?
Very common side effects: Hot flushes, asthenia, joint stiffness, arthritis, headache, nausea, rash etc. Common side effects: Hair thinning, allergic reactions, diarrhea, vomiting, somnolence etc.
Who should not take Anacare 1 mg?
Patients with severe renal impairment (Creatinine clearance less than 20 mL/min), patients with moderate to severe hepatic disease and known hypersensitivity to anastrozole or to any of the excipients. Oestrozen-containing therapies should not be co-administered with anastrazole as they would negate its pharmacological action.
What precautions should be taken with Anacare 1 mg?
Anastrozole is not recommended for use in children or in pre-menopausal women as safety and efficacy have not been established in these groups of patients. Anastrozole has not been investigated in patients with severe hepatic or severe renal impairment. The potential risk/benefit to such patients should be carefully considered before administration of Anastrozole. As Anastrozole lowers circulating…
Is Anacare 1 mg safe during pregnancy and breastfeeding?
Anastrozole is contraindicated in pregnant and lactating women.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.