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Anquil15 mg/3 ml
IM/IV Injection
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Medicine overview
Indications of Anquil 15 mg/3 ml
Anquil 15 mg/3 ml is indicated in-
Short-term treatment of insomnia.
Sedation in premedication before surgical or diagnostic procedures.
Theropeutic Class
Benzodiazepine hypnotics, Benzodiazepine sedatives
Pharmacology
Anquil 15 mg/3 ml binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites w/in the CNS, including the limbic system, reticular formation.
Absorption
Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to Cl ions, which results in hyperpolarisation (a less excitable state) and stabilisation.
Distribution
Benzodiazepine receptors and effects appear to be linked to the GABA-A receptors.
Dosage & Administration of Anquil 15 mg/3 ml
Notes:The duration of treatment with oral Anquil 15 mg/3 ml should not be more than of 2 weeks. In certain cases extension beyond the maximum treatment period may be necessary
Insomnia
Dosage:Adults: 7.5 mg to 15 mg daily (Oral) Elderly: 7.5 mg daily (Oral) Premedication: 7.5 mg to 15 mg, should be given 30-60 minutes before the procedure (Oral) Endoscopic or Cardiovascular procedures: Adult: initial dose is 2.5 mg (IV) Elderly & debilitated patients: 1-1.5 mg (IV) Induction of Anesthesia: Adult: 10-15 mg (IV) or 0.07-0.1 mg/Kg body weight, usually 5 mg (IM) Children: 0.15-0.20 mg/Kg (IM) Elderly & debilitated patients: 0.025-0.05 mg/Kg (IM) Rectal administration in children: for preoperative sedation, rectal administration of the ampoule solution is 0.35-0.45 mg/Kg, 20-30 min before induction of general anesthesia
| Condition | Dosage | Notes |
|---|---|---|
| The duration of treatment with oral Anquil 15 mg/3 ml should not be more than of 2 weeks. In certain cases extension beyond the maximum treatment period may be necessary | ||
| Insomnia | Adults: 7.5 mg to 15 mg daily (Oral) Elderly: 7.5 mg daily (Oral) Premedication: 7.5 mg to 15 mg, should be given 30-60 minutes before the procedure (Oral) Endoscopic or Cardiovascular procedures: Adult: initial dose is 2.5 mg (IV) Elderly & debilitated patients: 1-1.5 mg (IV) Induction of Anesthesia: Adult: 10-15 mg (IV) or 0.07-0.1 mg/Kg body weight, usually 5 mg (IM) Children: 0.15-0.20 mg/Kg (IM) Elderly & debilitated patients: 0.025-0.05 mg/Kg (IM) Rectal administration in children: for preoperative sedation, rectal administration of the ampoule solution is 0.35-0.45 mg/Kg, 20-30 min before induction of general anesthesia |
Dosage of Anquil 15 mg/3 ml
Oral dosage
Dosage:For adults: 7.5-15 mg daily
In elderly and debilitated patients
Dosage:The recommended dose is 7.5 mg
In premedication
Dosage:15 mg of Anquil 15 mg/3 ml should be given 30-60 minutes before the procedure
Intravenous administration
Dosage:Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg
Notes:In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg
Induction of Anesthesia
Dosage:The dose is 10-15 mg
Intramuscular administration
Dosage:Adult: 0.07-0.1 mg/kg body weight
Notes:The usual dose is about 5 mg
Children
Dosage:0.15-0.20 mg/kg Elderly and debilitated patients: 0.025-0.05 mg/kg Rectal administration in children: For preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min
Notes:before induction of general anesthesia
| Condition | Dosage | Notes |
|---|---|---|
| Oral dosage | For adults: 7.5-15 mg daily | |
| In elderly and debilitated patients | The recommended dose is 7.5 mg | |
| In premedication | 15 mg of Anquil 15 mg/3 ml should be given 30-60 minutes before the procedure | |
| Intravenous administration | Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg | In cases of severe illness and in elderly patients, the initial dose must be reduced to 1 to 1.5 mg |
| Induction of Anesthesia | The dose is 10-15 mg | |
| Intramuscular administration | Adult: 0.07-0.1 mg/kg body weight | The usual dose is about 5 mg |
| Children | 0.15-0.20 mg/kg Elderly and debilitated patients: 0.025-0.05 mg/kg Rectal administration in children: For preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min | before induction of general anesthesia |
Interaction of Anquil 15 mg/3 ml
Anquil 15 mg/3 ml can enhance the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics, antiepileptic drugs and sedative antihistamines.
Contraindications
Anquil 15 mg/3 ml must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome and with known hypersensitivity to benzodiazepines or to any component of the product
Side Effects of Anquil 15 mg/3 ml
At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Anquil 15 mg/3 ml, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.
Pregnancy & Lactation
Insufficient data are available on Anquil 15 mg/3 ml to assess its safety during pregnancy. But benzodiazepines adversely affect the human fetus. So their use should be avoided if there is safer alternative. Anquil 15 mg/3 ml is excreted through breast milk. Therefore, Anquil 15 mg/3 ml should not be used by the nursing mothers.
Precautions & Warnings
Anquil 15 mg/3 ml IV should be administered very slowly.
Overdose Effects of Anquil 15 mg/3 ml
Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil.
Storage Conditions
Protect from light and moisture, store in cool and dry place. Keep out of the reach of children.
Drug Classes
Benzodiazepine hypnotics, Benzodiazepine sedatives
Mode Of Action
The actions of benzodiazepines such as Anquil 15 mg/3 ml are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the central nervous system. Benzodiazepines increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia. Benzodiazepines bind to the benzodiazepine site on GABA-A receptors, which potentiates the effects of GABA by increasing the frequency of chloride channel opening. These receptors have been identified in different body tissues including the heart and skeletal muscle, although mainly appear to be present in the central nervous system.
Pregnancy
Anquil 15 mg/3 ml should be avoided during pregnancy unless there is no safer alternative. Since Anquil 15 mg/3 ml passes into breast milk, it should not be administered to breast-feeding mothers.
Frequently Asked Questions
What is Anquil 15 mg/3 ml used for?
Midazolam is indicated in- Short-term treatment of insomnia. Sedation in premedication before surgical or diagnostic procedures.
What is the dosage of Anquil 15 mg/3 ml?
Oral dosage: For adults: 7.5-15 mg daily. In elderly and debilitated patients: The recommended dose is 7.5 mg. In premedication: 15 mg of Midazolam should be given 30-60 minutes before the procedure. Intravenous administration: Endoscopic or Cardiovascular Procedures: In healthy adults, the initial dose is approximately 2.5 mg. In cases of severe illness and in elderly patients, the initial dose m…
What are the side effects of Anquil 15 mg/3 ml?
At the start of therapy, drowsiness during daytime, confusion, fatigue, headache and muscle weakness may occur which usually disappear with repeated administration. Following parenteral (IV or IM) administration of Midazolam, fluctuations in vital signs have been noted including respiratory depression, apnea, variations in blood pressure and pulse rate.
Who should not take Anquil 15 mg/3 ml?
Midazolam must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome and with known hypersensitivity to benzodiazepines or to any component of the product
What precautions should be taken with Anquil 15 mg/3 ml?
Midazolam IV should be administered very slowly.
Is Anquil 15 mg/3 ml safe during pregnancy and breastfeeding?
Insufficient data are available on Midazolam to assess its safety during pregnancy. But benzodiazepines adversely affect the human fetus. So their use should be avoided if there is safer alternative. Midazolam is excreted through breast milk. Therefore, Midazolam should not be used by the nursing mothers.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.