Apozyth 200 mg/5 ml is prescribed for infections (produced by susceptible organisms) in the upper respiratory tract, including sinusitis and pharyngitis/tonsillitis, the lower respiratory tract, including bronchitis and pneumonia, the otitis media, and the skin and soft tissue. Apozyth 200 mg/5 ml is recommended for the treatment of non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis in sexually transmitted illnesses in both men and women.

Theropeutic Class

Macrolides

Pharmacology

Apozyth 200 mg/5 ml belongs to the macrolide subclass of antibiotics known as azalide. In order to prevent microbial protein synthesis, Apozyth 200 mg/5 ml binds to the 50s ribosomal subunit of susceptible species. Moraxella catarrhalis, anaerobes such as Bacteroides fragilis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Haemophilus ducreyi, and Neisseria gonorrhoeae, as well as gram-positive and gram-negative bacteria such as Staphylococcus aureus, Streptoc Moreover, in vitro testing of Apozyth 200 mg/5 ml shown action against Campylobacter sp., Toxoplasma gondii, Treponema pallidum, Mycoplasma pneumoniae, Legionella pneumophila, and hominins.

Dosage of Apozyth 200 mg/5 ml

Adult: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given. Children: 10 mg/kg body weight once daily for 3 days for child over 6 months 200 mg (1 teaspoonful) for 3 days if body weight is 15-25 kg 300 mg (1½ teaspoonfuls) for 3 days if body weight is 26-35 kg; 400 mg (2 teaspoonfuls) for 3 days if body weight is 36-45 kg. In typhoid fever, 500 mg (21/2 teaspoonfuls) once daily for 7-10 days is given.

Administration of Apozyth 200 mg/5 ml

Procedure for reinstatement after suspension- Step 1: Thoroughly shake the bottle to break up the powder. Step 2: Fill the bottle with boiled and cooled water to the watermark on the label. Step 3: Mix the powder and water thoroughly to combine. Take Apozyth 200 mg/5 ml at least one hour before or two hours after eating.

Interaction of Apozyth 200 mg/5 ml

When food and antacids are present, Apozyth 200 mg/5 ml absorption is lessened. Due to the potential for ergotism brought on by an interaction between Apozyth 200 mg/5 ml and the cytochrome P-450 system, Apozyth 200 mg/5 ml should be avoided in patients who are receiving ergot alkaloids. With co-administration, care should be taken since macrolides raise the plasma levels of cyclosporin and digoxin. Warfarin, Theophylline, Carbamazepine, Methylprednisolone, or Cimetidine have not been found to interact with Apozyth 200 mg/5 ml.

Contraindications

Those who are hypersensitive to Apozyth 200 mg/5 ml or any other macrolide antibiotic should not take Apozyth 200 mg/5 ml. Ergot derivatives and Apozyth 200 mg/5 ml should not be administered together. Those with liver disorders should not use Apozyth 200 mg/5 ml.

Side Effects of Apozyth 200 mg/5 ml

Low-frequency side effects are experienced after taking Apozyth 200 mg/5 ml. A therapeutic withdrawal will reverse the adverse effects, which include nausea, vomiting, abdominal pain or cramps, flatulence, diarrhea, headaches, and skin rashes.

Pregnancy & Lactation

The Apozyth 200 mg/5 ml pregnancy category is B. Studies on animal reproduction have shown that Apozyth 200 mg/5 ml has no evidence of harming the fetus. Pregnant women have not been the subject of any good, controlled studies. Apozyth 200 mg/5 ml should only be used during pregnancy if no other suitable options are available, as research on animal reproduction are not always indicative of human response. The presence of Apozyth 200 mg/5 ml in breast milk is unknown. Hence, when giving Apozyth 200 mg/5 ml to nursing mothers, care should be taken.

Precautions & Warnings

It is advised to keep an eye out for any indications of superinfection with non-susceptible organisms, such as fungus when using any antibiotic. Those with renal impairment don't require a dose adjustment.

Overdose Effects of Apozyth 200 mg/5 ml

There is no information on Apozyth 200 mg/5 ml overdosage. Macrolide antibiotic overdose symptoms can include hearing loss, extreme nausea, vomiting, and diarrhea. The use of gastric lavage and other supportive treatments is advised.

Storage Conditions

Keep dry and away from heat and light. Keep out of children's reach.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.