ARB

ARB16 mg

Tablet

Candesartan Cilexetil

Square Pharmaceuticals PLC.

Product Code : 1242
MRP 10.07
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Medicine overview

Indications of ARB 16 mg

ARB 16 mg is indicated for hypertension, heart failure with impaired left ventricular systolic function.

Theropeutic Class

Angiotensin-ll receptor blocker

Pharmacology

ARB 16 mg is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract. Candesartan is angiotensin II receptor (type AT1) antagonist. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).

Dosage & Administration of ARB 16 mg

Hypertention: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.Heart failure: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.

Dosage of ARB 16 mg

Hypertention: initially 8 mg (hepatic impairment 2 mg, renal impairment or intravascular volume depletion 4 mg) once daily, increased if necessary at intervals of 4 weeks to max 32 mg once daily; usual maintenance dose 8 mg once daily.Heart failure: initially 4 mg once daily, increased at intervals of at least 2 weeks to target dose of 32 mg once daily or to max tolerated dose.

Interaction of ARB 16 mg

No significant drug interactions have been reported in studies of ARB 16 mg given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothiazide and oral contraceptives in healthy volunteers. Because candesartan is not metabolised by the cytochrome P-450 system and has no effects on P-450 enzymes, interactions with drugs that inhibit, or are metabolised by, those enzymes could not be expected.

Contraindications

Hypersensitivity to any component of this product. Pregnancy, breast-feeding, cholestasis.

Side Effects of ARB 16 mg

Side-effects are usually mild. Symptomatic hypotension including dizziness may occur, particularly in patients with intravascular volume depletion (e.g. those taking high dose diuretics). Hyperkalemia occurs occassionally; angioedema has also been reported with some angiotension II receptor antagonist. Also vertigo, headache; rarely hepatitis, blood disorders, hyponatraemia, back pain, arthralgia, myalgia, rash, urticaria, pruritous.

Pregnancy & Lactation

When pregnancy is detected, ARB 16 mg should be discontinued as soon as possible. It should be used in lactation.

Precautions & Warnings

Candesartan should be used with caution in renal artery stenosis, aortic or mitral valve stenosis and in obstructive hypertropic cardiomyopathy. Monitoring of plasma-potassium concentration is advised, particularly in the elderly and in patients with renal impairment; lower initial doses may be appropriate in these patients.

Storage Conditions

Store in a cool & dry place. Protect from light and moisture

Use In Special Populations

Use in pediatric: Safety and effectiveness in pediatric patients have not been established.

Drug Classes

Angiotensin-ll receptor blocker

Mode Of Action

ARB 16 mg is an ester prodrug that is hydrolysed in the body to the active form Candesartan during absorption from the gastro-intestinal tract. Candesartan is angiotensin II receptor (type AT1) antagonist. Candesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues (eg, vascular smooth muscle, adrenal gland).

Pregnancy

When pregnancy is detected, ARB 16 mg should be discontinued as soon as possible. It should be used in lactation.

Pediatric Uses

Use in pediatric: Safety and effectiveness in pediatric patients have not been established.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.