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Aripra

Aripra5 mg/5 ml

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Medicine overview

Indications of Aripra 5 mg/5 ml

Aripra 5 mg/5 ml is indicated for- Schizophrenia Schizoaffective disorder Acute manic and mixed episodes associated with Bipolar I Disorder Maintaining efficacy in patients with Bipolar I Disorder who are stabilized

Theropeutic Class

Atypical neuroleptic drugs

Pharmacology

Aripra 5 mg/5 ml is an atypical antipsychotic that has both dopamine and serotonin receptors activity.

Absorption

It is a partial agonist of dopamine D2 receptors that relieves the symptoms of schizophrenia.

Distribution

It is characterized as a dopamine system stabilizer.

Metabolism

It is a potent partial agonist at serotonin 5-HT1A receptors and antagonist at 5-HT2A receptors.

Excretion

This is associated with improvement of depressive, cognitive and negative symptoms.

Dosage & Administration of Aripra 5 mg/5 ml

For Schizophrenia
Dosage:10 to 15 mg, once daily, without regard to food
Notes:Dose increment should not be made before 2 weeks, the time needed to achieve steady state
For Bipolar mania
Dosage:30 mg, once daily, without regard to food

Dosage of Aripra 5 mg/5 ml

For Schizophrenia
Dosage:10 to 15 mg, once daily, without regard to food
Notes:Dose increment should not be made before 2 weeks, the time needed to achieve steady state
For Bipolar mania
Dosage:30 mg, once daily, without regard to food

Interaction of Aripra 5 mg/5 ml

Caution should be exercised when aripipazole is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Aripra 5 mg/5 ml clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Aripra 5 mg/5 ml elimination and cause increased blood levels.

Contraindications

Aripra 5 mg/5 ml is contraindicated in patients who are hypersensitive to it or to any component of this product.

Side Effects of Aripra 5 mg/5 ml

Headache, constipation, asthenia, nausea, dyspepsia, vomiting, coughing, abdominal pain.

Pregnancy & Lactation

Aripra 5 mg/5 ml should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking Aripra 5 mg/5 ml.

Precautions & Warnings

Aripra 5 mg/5 ml may be associated with orthostatic hypotension (orthostatic lightheadedness).Aripra 5 mg/5 ml should be used with caution in patients with known cardiovascular disease (myocardial infarction or ischaemic heart disease, heart failure or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment with antihypertensive medications).Seizures occurred in Aripra 5 mg/5 ml-treated patients. As with other antipsychotic drugs, Aripra 5 mg/5 ml should be used cautiously in patients with Alzheimer's dementia.Aripra 5 mg/5 ml is not approved for the treatment of patients with dementia-related psychosis.

Overdose Effects of Aripra 5 mg/5 ml

Aripra 5 mg/5 ml at doses up to 1080 mg causes no fatalities. The signs and symptoms observed with Aripra 5 mg/5 ml overdose included nausea, vomiting, asthenia, diarrhea, and somnolence.

Drug Classes

Atypical neuroleptic drugs

Mode Of Action

Aripra 5 mg/5 ml is an atypical antipsychotic that has both dopamine and serotonin receptors activity. It is a partial agonist of dopamine D2 receptors that relieves the symptoms of schizophrenia. It is characterized as a dopamine system stabilizer. It is a potent partial agonist at serotonin 5-HT1A receptors and antagonist at 5-HT2A receptors. This is associated with improvement of depressive, cognitive and negative symptoms.

Pregnancy

Aripra 5 mg/5 ml should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking Aripra 5 mg/5 ml.

Frequently Asked Questions

What is Aripra 5 mg/5 ml used for?

Aripiprazole is indicated for- Schizophrenia Schizoaffective disorder Acute manic and mixed episodes associated with Bipolar I Disorder Maintaining efficacy in patients with Bipolar I Disorder who are stabilized

What is the dosage of Aripra 5 mg/5 ml?

For Schizophrenia: 10 to 15 mg, once daily, without regard to food. Dose increment should not be made before 2 weeks, the time needed to achieve steady state.For Bipolar mania: 30 mg, once daily, without regard to food.

What are the side effects of Aripra 5 mg/5 ml?

Headache, constipation, asthenia, nausea, dyspepsia, vomiting, coughing, abdominal pain.

Who should not take Aripra 5 mg/5 ml?

Aripiprazole is contraindicated in patients who are hypersensitive to it or to any component of this product.

What precautions should be taken with Aripra 5 mg/5 ml?

Aripiprazole may be associated with orthostatic hypotension (orthostatic lightheadedness).Aripiprazole should be used with caution in patients with known cardiovascular disease (myocardial infarction or ischaemic heart disease, heart failure or conduction abnormalities), cerebrovascular disease, or conditions that would predispose patients to hypotension (dehydration, hypovolemia, and treatment wi…

Is Aripra 5 mg/5 ml safe during pregnancy and breastfeeding?

Aripiprazole should not be used in pregnancy as no human trial is performed. Patients should be advised not to breast feed an infant if they are taking aripiprazole.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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