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Cotrim DS800 mg+160
Square Pharmaceuticals PLC.
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Avlotrin DS800 mg+160 mg
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Medicine overview
Indications of Avlotrin DS 800 mg+160 mg
Avlotrin DS 800 mg+160 mg is bactericidal in vitro to a wide range of Gram-positive and Gram-negative organismsincluding StreptococcusStaphylococcusPneumococcusNeisseriaB. catarrhalisEscherichia coliKlebsiellaProteus spp.HaemophilusSalmonellaShigellaVibrio choleraeBrucellaPneumocystis cariniiNocardia and Bordetella. A particularly high degree of activity is exhibited against Haemophilus influenzaeE. coli and Proteus spp.including acute and chronic bronchitis (treatment and prophylaxis)bronchiectasislung abscesslobar and broncho-pneumoniaPneumocystis carinii pneumonitissinusitis and otitis media. Genito-urinary tract infectionsincluding urethritisacute and chronic cystitispyelonephritisprostatitis and gonorrhoea. Gastro-intestinal tract infectionscaused by Salmonella typhi and Salmonella paratyphiincluding the chronic carrier state. Other infectionsacute brucellosisskin infections including pyodermaabscesses and wound infectionssepticaemiabacillary dysentery and cholera (as an adjuvant to fluid and electrolyte replacement)nocardiosis and mycetoma.
Theropeutic Class
Anti-diarrhoeal Antimicrobial drugs, Sulphonamides & Trimethoprim
Pharmacology
Avlotrin DS 800 mg+160 mg having broad spectrum bactericidal activity against a wide range of gram-positive & gram-negative bacteria and some protozoa.
Absorption
Co-trimoxazole containing Trimethoprim and Sulphamethoxazole in a 1:5 combination exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid in the microorganism.
Dosage & Administration of Avlotrin DS 800 mg+160 mg
Avlotrin DS 800 mg+160 mg double strength tablet
Dosage:Over 12 years For mild to moderate infections: 1 tablet twice daily
For severe infections
Dosage:1.5 tablets twice daily
Long term therapy (>14 days)
Dosage:0.5 tablet twice daily
Gonorrhoea
Dosage:2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours
Avlotrin DS 800 mg+160 mg tablet
Dosage:over 12 years For mild to moderate infections: 2 tablets twice daily
For severe infections
Dosage:2 tablets thrice daily
Long term therapy
Dosage:(>14 days): 1 tablet twice daily
Avlotrin DS 800 mg+160 mg suspension
Dosage:Under 12 years 6-12 years: 2 teaspoonful twice daily
Notes:6 month-5 years: 1 teaspoonful twice daily. 6 weeks-6 months: 0.5 teaspoonful twice daily
| Condition | Dosage | Notes |
|---|---|---|
| Avlotrin DS 800 mg+160 mg double strength tablet | Over 12 years For mild to moderate infections: 1 tablet twice daily | |
| For severe infections | 1.5 tablets twice daily | |
| Long term therapy (>14 days) | 0.5 tablet twice daily | |
| Gonorrhoea | 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours | |
| Avlotrin DS 800 mg+160 mg tablet | over 12 years For mild to moderate infections: 2 tablets twice daily | |
| For severe infections | 2 tablets thrice daily | |
| Long term therapy | (>14 days): 1 tablet twice daily | |
| Avlotrin DS 800 mg+160 mg suspension | Under 12 years 6-12 years: 2 teaspoonful twice daily | 6 month-5 years: 1 teaspoonful twice daily. 6 weeks-6 months: 0.5 teaspoonful twice daily |
Contraindications
Hypersensitivity to trimethoprim or sulphonamides.
Patients with documented megaloblastic anaemia due to folate deficiency.
Patients showing marked liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency.
Side Effects of Avlotrin DS 800 mg+160 mg
The side effects like crystalluria, allergic reactions, haemolysis, thrombocytopenia, neutropenia, agranulocytosis etc. have been reported rarely with Sulphamethoxazole-Trimethoprim combination. Other side effects are less serious in nature such as malaise, headache, nausea and vomiting. These are normally transient and do not require withdrawal of treatment.
Pregnancy & Lactation
Pregnancy and during the nursing period, because sulphonamides pass the placenta and are excreted in the breast milk and may cause kernicterus.
Precautions & Warnings
Prolonged full dose treatment with sulfamethoxazole-trimethoprim combination is associated with the risk of macrocytic anaemia due to the drug’s interference in the conversion of Folic acid into Folinic acid. If this occurs, it can be reversed by giving Folinic acid. Care should be taken when giving this combination to diabetic patients receiving sulphonylurea drug for possible potentiation of action of sulphonylurea.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Frequently Asked Questions
What is Avlotrin DS 800 mg+160 mg used for?
Cotrimoxazole is bactericidal in vitro to a wide range of Gram-positive and Gram-negative organisms, including Streptococcus, Staphylococcus, Pneumococcus, Neisseria, B. catarrhalis, Escherichia coli, Klebsiella, Proteus spp., Haemophilus, Salmonella, Shigella, Vibrio cholerae, Brucella, Pneumocystis carinii, Nocardia and Bordetella. A particularly high degree of activity is exhibited against Haem…
What is the dosage of Avlotrin DS 800 mg+160 mg?
Cotrimoxazole double strength tablet: Over 12 years For mild to moderate infections: 1 tablet twice daily. For severe infections: 1.5 tablets twice daily. Long term therapy (>14 days): 0.5 tablet twice daily. Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours. Cotrimoxazole tablet: over 12 years For mild to moderate infections: …
What are the side effects of Avlotrin DS 800 mg+160 mg?
The side effects like crystalluria, allergic reactions, haemolysis, thrombocytopenia, neutropenia, agranulocytosis etc. have been reported rarely with Sulphamethoxazole-Trimethoprim combination. Other side effects are less serious in nature such as malaise, headache, nausea and vomiting. These are normally transient and do not require withdrawal of treatment.
Who should not take Avlotrin DS 800 mg+160 mg?
Hypersensitivity to trimethoprim or sulphonamides. Patients with documented megaloblastic anaemia due to folate deficiency. Patients showing marked liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency.
What precautions should be taken with Avlotrin DS 800 mg+160 mg?
Prolonged full dose treatment with sulfamethoxazole-trimethoprim combination is associated with the risk of macrocytic anaemia due to the drug’s interference in the conversion of Folic acid into Folinic acid. If this occurs, it can be reversed by giving Folinic acid. Care should be taken when giving this combination to diabetic patients receiving sulphonylurea drug for possible potentiation of act…
Is Avlotrin DS 800 mg+160 mg safe during pregnancy and breastfeeding?
Pregnancy and during the nursing period, because sulphonamides pass the placenta and are excreted in the breast milk and may cause kernicterus.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.