
Beklo5 mg
Opsonin Pharma Ltd.

Tablet
Centrally acting Skeletal Muscle Relaxants
Beclovan 5 mg is an effective muscle relaxant and antispastic agent that primarily acts at the spinal level.
While its exact mode of action is not fully understood, Beclovan 5 mg works by stimulating GABAB receptors, which inhibits the release of glutamate and aspartate, thereby affecting both monosynaptic and polysynaptic reflexes.
It may also have central nervous system (CNS) depressant effects at intraspinal sites.
Notably, Beclovan 5 mg does not impact neuromuscular transmission.
Beclovan 5 mg exhibits an antinociceptive (pain-relieving) effect, although its clinical significance remains uncertain.
Beclovan 5 mg should be taken with a small amount of liquid during meals. The dosing regimen for Beclovan 5 mg varies for adults and children.
In adults, it's typically administered in divided doses, preferably three times a day. The aim is to use the lowest effective dose.
For adults, the therapy usually begins with a low dose and is then increased gradually to achieve the best response, typically falling within the range of 30-80 mg daily. Additional increases may be necessary but should generally not exceed a maximum daily dose of 80 mg.
For children, treatment should begin with an extremely low dose, such as 0.3 mg/kg per day, divided into multiple doses. The dose can then be cautiously increased at 1-2 week intervals until it meets the child's specific needs.
The usual maintenance dose for children typically falls within the range of 0.75 to 2 mg/kg of body weight per day.
For children over 10 years of age, a maximum daily dose of 2.5 mg/kg of body weight may be considered.
Beclovan 5 mg is contraindicated in patients with hypersensitivity to any component of this product.
The common adverse reactions associated with Beclovan 5 mg include drowsiness, dizziness, weakness, and fatigue.
More serious adverse reactions are less common, but can occur. These include:
Muscular hypotonia, or low muscle tone, can also occur with Beclovan 5 mg. This is usually relieved by adjusting the dosage.
Pregnancy category B3. The safety of using Beclovan 5 mg during pregnancy has not been established, as it can cross the placental barrier. Administration to pregnant women should only occur when the physician concludes that the potential benefits outweigh the possible risks. Beclovan 5 mg is excreted in breast milk, but available evidence suggests that the quantities are so minimal that no adverse effects on the infant are expected.
Lower doses (approximately 5 mg per day) should be considered for patients with impaired renal function or those undergoing chronic hemodialysis. Patients who not only have spasticity but also suffer from psychotic disorders, schizophrenia, depressive or manic disorders, or confusional states should be treated cautiously and closely monitored, as exacerbations of these conditions may occur. In patients with epilepsy and muscle spasticity, Beclovan 5 mg may be used under appropriate supervision, provided that adequate anticonvulsive therapy is continued. It's important to note that lowering the convulsion threshold may occur, and seizures have been reported after the cessation of Beclovan 5 mg therapy or in cases of overdose.
Caution should be exercised in patients with a history of peptic ulcers, cerebrovascular diseases, or hepatic, renal, or respiratory failure. Vigilant monitoring of respiratory and cardiovascular function is essential, especially in those with cardiopulmonary disease and respiratory muscle weakness. While Beclovan 5 mg treatment may improve neurogenic disturbances affecting bladder emptying, individuals with preexisting sphincter hypertonia may experience acute retention of urine in these circumstances. It's important to note that Beclovan 5 mg has not significantly benefited patients with stroke, and they have shown poor tolerance to the medication. For individuals with hepatic diseases or diabetes mellitus, appropriate laboratory tests should be conducted periodically to ensure that there are no medication-induced changes in these underlying conditions.
Gastric lavage is important in case of severe overdose.
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Centrally acting Skeletal Muscle Relaxants
Beclovan 5 mg inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABAB receptors, which in turn inhibits the release of glutamate and aspartate. Additionally, it may act at intraspinal sites, leading to CNS depression. Beclovan 5 mg also demonstrates an antinociceptive effect.
What is Beclovan 5 mg used for?
Baclofen is indicated for the treatment of spasticity, including flexor spasms, associated pain, clonus, muscular rigidity, as well as skeletal muscle spasms resulting from conditions such as multiple sclerosis, rheumatic disorders, spinal cord injuries, other spinal cord diseases, cerebrovascular accidents, neoplastic, or degenerative brain diseases.
What is the dosage of Beclovan 5 mg?
Baclofen should be taken with a small amount of liquid during meals. The dosing regimen for Baclofen varies for adults and children. In adults, it's typically administered in divided doses, preferably three times a day. The aim is to use the lowest effective dose. For adults, the therapy usually begins with a low dose and is then increased gradually to achieve the best response, typically falling …
What are the side effects of Beclovan 5 mg?
The common adverse reactions associated with Baclofen include drowsiness, dizziness, weakness, and fatigue. More serious adverse reactions are less common, but can occur. These include: Central nervous system effects: headaches, insomnia, euphoria, excitement, depression, confusion, hallucinations, paraesthesia, nightmares, muscle pain, tinnitus, slurred speech, coordination disorders, tremors, ri…
Who should not take Beclovan 5 mg?
Baclofen is contraindicated in patients with hypersensitivity to any component of this product.
What precautions should be taken with Beclovan 5 mg?
Lower doses (approximately 5 mg per day) should be considered for patients with impaired renal function or those undergoing chronic hemodialysis. Patients who not only have spasticity but also suffer from psychotic disorders, schizophrenia, depressive or manic disorders, or confusional states should be treated cautiously and closely monitored, as exacerbations of these conditions may occur. In pat…
Is Beclovan 5 mg safe during pregnancy and breastfeeding?
Pregnancy category B3. The safety of using Baclofen during pregnancy has not been established, as it can cross the placental barrier. Administration to pregnant women should only occur when the physician concludes that the potential benefits outweigh the possible risks. Baclofen is excreted in breast milk, but available evidence suggests that the quantities are so minimal that no adverse effects o…
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