Bendex500 mg

Name: Bendex 500 mg
Brand: Bendex
Price: 2.48 BDT
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Medicine overview

Indications of Bendex 500 mg

Bendex 500 mg is indicated for the treatment of threadwormswhipwormsroundworms and hookworms.

Theropeutic Class

Anthelmintic

Pharmacology

Bendex 500 mg is a synthetic derivative of benzimidazole with a potent anthelmintic activity against the most common nematodes and some cestodes.

Absorption

Parasite immobilization and death occur slowly and clearance from the gastro-intestinal tract may not be completed up to 3 days after administration.

Distribution

The effect of the drug is due to its ability to inhibit glucose uptake irreversibly but it does not affect blood glucose concentration in the host, even in high doses. Bendex 500 mg does not necessitate any dosage calculation since the same dosage is used for children and adults.

Metabolism

It can be taken at any time and no special procedures such as purging, use of laxatives and/or dietary changes are required.

Excretion

Parasite immobilization and death occur slowly and clearance from the gastro-intestinal tract may not be completed up to 3 days after administration.

Dosage of Bendex 500 mg

Adult and Child over 2 years- Threadworms

Dosage:100 mg or 1 teaspoonful: Single dose

Whipworms, Roundworms, Hookworms

Dosage:100 mg or 1 teaspoonful: Twice daily for 3 days

Notes:If reinfection occurs the second dose may be needed after 2 weeks

Condition	Dosage	Notes
Adult and Child over 2 years- Threadworms	100 mg or 1 teaspoonful: Single dose
Whipworms, Roundworms, Hookworms	100 mg or 1 teaspoonful: Twice daily for 3 days	If reinfection occurs the second dose may be needed after 2 weeks

Administration of Bendex 500 mg

May be taken with or without food.

Interaction of Bendex 500 mg

Preliminary evidence suggests that cimetidine inhibits Bendex 500 mg metabolism and may result in an increase in plasma concentration.

Contraindications

Bendex 500 mg is contraindicated in patients with known hypersensitivity to Bendex 500 mg, or to any component of the formulation.

Side Effects of Bendex 500 mg

Gastrointestinal: Transient symptoms of abdominal pain and diarrhoea in case of massive infection and expulsion of worms. Hypersensitivity: Rash, urticaria and angioedema have been observed on rare occasions. Central Nervous System: Very rare cases of convulsions have been reported. Haematologic: Neutropenia and agranulocytosis.

Pregnancy & Lactation

Bendex 500 mg should not be administered during pregnancy and in women thought to be pregnant. It is not known whether Bendex 500 mg or its metabolites are secreted in human breast milk. Thus Bendex 500 mg should not be used during lactation unless the potential benefits are considered to outweigh the potential risk associated with treatment.

Precautions & Warnings

General: Periodic assessment of organ system functions, including haematopoietic and hepatic, is advisable during prolonged therapy.Information for Patients: Patients should be informed of the potential risk to the foetus in women taking Bendex 500 mg during pregnancy, especially during the first trimester. Patients should also be informed that cleanliness is important to prevent reinfection & transmission of the infection.

Overdose Effects of Bendex 500 mg

In the event of accidental overdosage, gastrointestinal complaints lasting up to a few hours may occur. Vomiting and purging should be induced.

Storage Conditions

Store in a cool (Below 25°C temperature) and dry place, protected from light. Keep out of the reach of children.

Drug Classes

Anthelmintic

Mode Of Action

Bendex 500 mg is a synthetic broad-spectrum anthelmintic that is active against most nematodes and some other worms. Bendex 500 mg is principally used in the treatment of intestinal nematode infection. Bendex 500 mg inhibits the formation of the worms' microtubules and causes the worms' glucose depletion. After oral administration about 2-10% of oral dose is absorbed from Gl tract and peak plasma concentration occurs within 30 minutes to 7 hours. Bendex 500 mg is highly bound to plasma protein. Elimination half-life is 2.8 to 9 hours.

Pregnancy

Bendex 500 mg is not recommended in pregnant women. It is not known whether Bendex 500 mg is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when it is administered to a nursing mother.

Pediatric Uses

Paediatric use: The drug has not been extensively studied in children under two years; therefore, in the treatment of children under two years the relative benefit/risk should be considered.

Frequently Asked Questions

What is Bendex 500 mg used for?

Mebendazole is indicated for the treatment of threadworms, whipworms, roundworms and hookworms.

What is the dosage of Bendex 500 mg?

Adult and Child over 2 years- Threadworms: 100 mg or 1 teaspoonful: Single dose. Whipworms, Roundworms, Hookworms: 100 mg or 1 teaspoonful: Twice daily for 3 days. If reinfection occurs the second dose may be needed after 2 weeks.

What are the side effects of Bendex 500 mg?

Who should not take Bendex 500 mg?

Mebendazole is contraindicated in patients with known hypersensitivity to Mebendazole, or to any component of the formulation.

What precautions should be taken with Bendex 500 mg?

General: Periodic assessment of organ system functions, including haematopoietic and hepatic, is advisable during prolonged therapy.Information for Patients: Patients should be informed of the potential risk to the foetus in women taking mebendazole during pregnancy, especially during the first trimester. Patients should also be informed that cleanliness is important to prevent reinfection & trans…

Is Bendex 500 mg safe during pregnancy and breastfeeding?

Mebendazole should not be administered during pregnancy and in women thought to be pregnant. It is not known whether mebendazole or its metabolites are secreted in human breast milk. Thus Mebendazole should not be used during lactation unless the potential benefits are considered to outweigh the potential risk associated with treatment.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.