Betameson20 gm
Cream
Betamethasone Dipropionate
Square Pharmaceuticals PLC.
Product Code : 2132
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Medicine overview
Indications of Betameson 20 gm
Betameson 20 gm cream and ointment isindicated for the relief of the inflammatory and pruritic manifestations of resistant or severe corticosteroid-responsive dermatoses. These include-
Atopic eczema
Nummular eczema
Contact dermatitis
Neurodermatitis
Anogenital and senile pruritus
Lichen planus
Psoriasis
Theropeutic Class
Corticosteroid
Pharmacology
Betameson 20 gm is a potent topical corticosteroid. Topical corticosteroids have antiinflammatory, antipruritic and vasoconstrictive actions when administered. Betamethasone acts by inhibition of phospholipase A2 activity and reduces the formation of prostaglandins and leukotrienes in local tissues.
Dosage & Administration of Betameson 20 gm
Apply a thin film once or twice daily to cover completely the affected area. Patients with chronic psoriasis who have achieved at least a marked improvement in their psoriatic lesion (i.e., approximately 80% improvement) with Betameson 20 gm may be maintained in remission with a pulse dosing regimen consisting of three consecutive applications of up to 3.5 g each of Betameson 20 gm cream and ointment, twelve hours apart (e.g., morning, evening, following morning) to the previously affected areas once each week. For this purpose, Betameson 20 gm cream and ointment should be applied to the lesion sites previously affected and treated. Patients on this pulse dose regimen who relapse should be reverted back to the conventional dosing regimen.
Dosage of Betameson 20 gm
Apply a thin film once or twice daily to cover completely the affected area. Patients with chronic psoriasis who have achieved at least a marked improvement in their psoriatic lesion (i.e., approximately 80% improvement) with Betameson 20 gm may be maintained in remission with a pulse dosing regimen consisting of three consecutive applications of up to 3.5 g each of Betameson 20 gm cream and ointment, twelve hours apart (e.g., morning, evening, following morning) to the previously affected areas once each week. For this purpose, Betameson 20 gm cream and ointment should be applied to the lesion sites previously affected and treated. Patients on this pulse dose regimen who relapse should be reverted back to the conventional dosing regimen.
Interaction of Betameson 20 gm
There is no evidence of any kind of interaction.
Contraindications
Hypersensitivity to Betameson 20 gm, other corticosteroids or any components in this preparation. Like other topical corticosteroids, Betameson 20 gm is contraindicated in viral infections of the skin, such as vaccinia, varicella and Herpes simplex, also tuberculosis, acne rosacea, fungal skin infections (moniliasis), perioral dermatitis and ulcerative conditions.
Side Effects of Betameson 20 gm
The most frequent side effects reported with Betameson 20 gm are mild to moderate transient burning/stinging, dry skin, pruritus, irritation and folliculitis. Rarely reported adverse effects include tingling, prickly skin/tightening or cracking of skin, warm feeling,laminar scaling and perilesional scaling,follicular rash, skin atrophy, erythema, urticaria, vesiculation, telangiectasia, acneiform papules and hyperaesthesia.Adverse reactions reported with the use of the Betameson 20 gm ointment pulse dose regimen were mild intermittent hypertension and paraesthesia. Other local adverse reactions that have been reported with the use of topical corticosteroids include: itching, hypertrichosis, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, striae, miliaria and exacerbation of untreated infections
Precautions & Warnings
Betameson 20 gm should not be used in or near the eyes, as there is a potential risk of developing glaucoma and cataract. If irritation or sensitisation develops with the use of Betameson 20 gm, treatment should be discontinued and appropriate therapy instituted. In the presence of an infection, an appropriate antifungal or antibacterial agent should be administered. If a favourable response does not occur promptly, Betameson 20 gm should be discontinued until the infection has been controlled adequately. Corticosteroids are known to be absorbed percutaneously, therefore in patients under prolonged and extensive topical treatment, the possibility of systemic effects should be kept in mind. Betameson 20 gm is not intended for use under occlusive dressings since this will also increase systemic absorption of the corticosteroid. In infants the napkin may act as an occlusive dressing and increase absorption. Suitable precautions should be taken when using topical corticosteroids in patients with stasis dermatitis and other skin diseases with impaired circulation. Prolonged use of topical corticosteroid preparations may produce striae or atrophy of the skin or subcutaneous tissue. If this occurs, treatment should be discontinued.
Overdose Effects of Betameson 20 gm
Acute overdose with the ointment is unlikely and would not be expected to lead to a life-threatening situation. The ointment should not be used for longer than the prescribed time period.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Drug Classes
Corticosteroid
Mode Of Action
Betameson 20 gm is a topical corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties. Betameson 20 gm induces peptides called lipocortins. Lipocortins antagonize phospholipase A2, an enzyme that causes the breakdown of leukocyte lysosomal membranes to release arachidonic acid. This action decreases the subsequent formation and release of endogenous inflammatory mediators including prostaglandins, kinins, histamine. Pharmacokinetics: Betameson 20 gm can be absorbed from normal intact skin. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver.lt excreted by the kidneys.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.