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G-Iron200 mg/5 m
Gonoshasthaya Pharmaceuticals Limited
৳22.50
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Medicine overview
Indications of Bioron
Established / FDA-Approved Uses
- Treatment of iron-deficiency anemia: Bioron is indicated for the treatment of anemia caused by iron deficiency, confirmed by low serum ferritin, low hemoglobin, and other laboratory findings consistent with iron deficiency.
- Prevention of iron-deficiency anemia: Bioron is used to prevent iron deficiency in individuals at increased risk, including pregnant women, infants born prematurely or with low birth weight, children in periods of rapid growth, and people on iron-poor diets.
Guideline-Supported Uses
- Iron supplementation during pregnancy and lactation: Bioron is recommended by obstetric guidelines to meet the increased iron requirements of pregnancy and to prevent maternal and fetal complications of iron-deficiency anemia.
- Chronic blood loss states: used as adjunct therapy to replace iron lost from chronic gastrointestinal bleeding, heavy menstrual bleeding, or regular blood donation, once the underlying cause has been identified and addressed.
Adjunct / Combination Uses
- Bioron may be combined with other hematinics (e.g., folic acid, vitamin B12, vitamin C) as adjunct therapy in specific anemia protocols where multiple deficiencies coexist; in such cases it is used alongside, not as a replacement for, treatment of the other deficiencies.
Bioron does not treat anemia that is not due to iron deficiency (e.g., anemia of chronic disease, hemolytic anemia, or vitamin B12/folate deficiency anemia) and should not be used for these without confirmed iron deficiency.
Composition
Each tablet/capsule of Ferrous Sulfate typically contains Ferrous Sulfate equivalent to a specified amount of elemental iron (commonly 200 mg Ferrous Sulfate providing approximately 60-65 mg elemental iron, or dried/exsiccated Ferrous Sulfate 150-200 mg providing a similar amount of elemental iron). Oral liquid formulations (elixir/drops) contain Ferrous Sulfate in a lower per-mL concentration for pediatric or dose-titrated use. Exact strength varies by manufacturer and dosage form; refer to the specific product label for the elemental iron content.
Description
Bioron is an iron salt used as an oral iron replacement product. It supplies ferrous (Fe2+) iron, the form ofiron that is most readily absorbed from the gastrointestinal tract, to replenish body iron stores and supporthemoglobin synthesis. Bioron is one of the oldest and most widely used oral iron preparations and is considered afirst-line, cost-effective treatment for iron-deficiency anemia.
Bioron is available in immediate-release tablets, enteric-coated/extended-release tablets, capsules, and oralliquid (elixir/drops) formulations for adults and children.
Therapeutic Class
Bioron belongs to the therapeutic class of hematinics / antianemic preparations, specifically oral iron (ferrous) salts used to treat and prevent iron-deficiency anemia.
Pharmacology
Mechanism
Ferrous Sulfate dissociates in the gastrointestinal tract to release ferrous (Fe2+) iron, which is the form activelyabsorbed by enterocytes, predominantly in the duodenum and proximal jejunum, via the divalent metal transporter(DMT1). Absorbed iron is either stored intracellularly as ferritin or transported into the bloodstream viaferroportin, where it binds to transferrin for delivery to the bone marrow. There, iron is incorporated intoprotoporphyrin IX to form heme, an essential component of hemoglobin, enabling normal erythropoiesis and oxygentransport. Iron is also a cofactor for myoglobin and several enzymes involved in cellular respiration and energymetabolism.
Absorption
Absorption of iron from Ferrous Sulfate is enhanced by an acidic gastric environment and by vitamin C, and is reduced byfood, antacids, calcium, and certain other agents (see Interactions). Absorption is inversely related to bodyiron stores - it increases when iron stores are depleted and decreases as they are replenished.
Dosage & Administration of Bioron
Adult Dose - Iron-Deficiency Anemia (Treatment)
| Indication | Typical Adult Dose |
|---|---|
| Treatment of iron-deficiency anemia | Bioron providing 100-200 mg elemental iron per day, in 1-3 divided doses (e.g., Bioron 325 mg tablet, providing about 65 mg elemental iron, once to three times daily) |
| Prevention of iron deficiency (e.g., pregnancy) | Bioron providing 30-60 mg elemental iron once daily |
Some clinicians and recent evidence favor alternate-day dosing of Bioron (rather than multiple daily doses) toimprove fractional iron absorption and reduce gastrointestinal side effects; the prescribing physician'sinstructions should be followed.
Pediatric Dose
| Indication | Typical Pediatric Dose |
|---|---|
| Treatment of iron-deficiency anemia | Bioron providing 3-6 mg/kg/day elemental iron, in 1-3 divided doses (physician/weight-guided) |
| Prevention of iron deficiency (infants/children) | Bioron providing 1-2 mg/kg/day elemental iron, once daily |
Renal/Hepatic Impairment
No well-established dose adjustment of Bioron is required for renal or hepatic impairment, as oral iron is notsignificantly cleared by the kidney or metabolized by the liver; however, patients with hepatic disease shoulduse Bioron under medical supervision because of a theoretical risk of iron accumulation.
Administration Notes
- For best absorption, take Bioron on an empty stomach, about 1 hour before or 2 hours after meals.
- If gastrointestinal upset occurs, Bioron may be taken with food, but this reduces the amount of iron absorbed.
- Do not take Bioron at the same time as antacids, calcium supplements, dairy products, tea, or coffee - separatethese by at least 2 hours (see Interactions).
- Swallow tablets/capsules whole with water; do not crush enteric-coated or extended-release forms.
Administration of Bioron
Bioron should ideally be taken on an empty stomach (1 hour before or 2 hours after meals) with a full glass ofwater for optimal absorption. It may be taken with a small amount of food if stomach upset occurs, though thislowers absorption. Avoid taking Bioron together with antacids, calcium, dairy, tea, or coffee; separate these by atleast 2 hours. Do not lie down for 10 minutes after taking liquid or tablet forms of Bioron to reduce the risk ofthroat irritation.
Interaction of Bioron
| Interacting Agent | Effect / Mechanism | Recommendation |
|---|---|---|
| Antacids, calcium supplements, dairy products | Reduce absorption of iron from Bioron by raising gastric pH and/or forming insoluble complexes | Separate administration by at least 2 hours |
| Tea, coffee | Tannins bind iron and reduce absorption of Bioron | Avoid taking together; separate by at least 2 hours |
| Tetracyclines (e.g., doxycycline) | Bioron chelates tetracyclines, reducing absorption of both the antibiotic and the iron | Separate administration by at least 2-3 hours |
| Fluoroquinolones (e.g., ciprofloxacin, levofloxacin) | Bioron chelates fluoroquinolones, markedly reducing antibiotic absorption and efficacy | Separate administration by at least 2 hours (fluoroquinolone before or well after Bioron) |
| Levothyroxine | Bioron reduces absorption of levothyroxine, which may reduce thyroid hormone efficacy | Separate administration by at least 4 hours |
| Levodopa, methyldopa | Bioron may reduce absorption and efficacy of these agents via chelation | Separate administration by at least 2 hours; monitor clinical response |
| Proton pump inhibitors / H2-blockers | Reduced gastric acidity decreases absorption of iron from Bioron | Monitor response to iron therapy; dose adjustment or alternative iron formulation may be considered |
Contraindications
Ferrous Sulfate is contraindicated in:
- Known hypersensitivity to Ferrous Sulfate or any component of the formulation.
- Hemochromatosis, hemosiderosis, or other conditions of iron overload.
- Hemolytic anemia or other anemias not caused by iron deficiency, in which additional iron would risk harmful iron accumulation.
- Repeated blood transfusions in patients who are not iron deficient (risk of iron overload).
Side Effects of Bioron
Common (Expected/Usually Not Serious)
- Nausea, epigastric/abdominal discomfort
- Constipation or, less commonly, diarrhea
- Dark or black-colored stools (a harmless, expected effect of unabsorbed iron - not a sign of bleeding, though patients with unexplained melena should still seek medical evaluation)
- Metallic taste; temporary staining of teeth with liquid formulations (rinse mouth or use a straw)
Less Common
- Vomiting, heartburn
- Allergic skin reactions (rash, itching) in sensitive individuals
Serious (Rare, Usually Related to Overdose)
Iron overdose from Bioron can cause serious, potentially fatal toxicity, especially in young children - seeOverdose section. Any signs of severe abdominal pain, vomiting blood, black tarry stools with instability, orlethargy after excessive intake require immediate emergency care.
Pregnancy & Lactation
Pregnancy: Bioron is commonly recommended during pregnancy at appropriate doses to prevent andtreat iron-deficiency anemia, which is common in pregnancy and associated with adverse maternal and fetaloutcomes if untreated. As with any medication in pregnancy, Bioron should be used only as advised by a physician,at the dose and duration recommended, since excessive iron intake beyond physiological requirement is notadvised; do not exceed the prescribed dose. Consult a physician before starting or adjusting Bioron duringpregnancy.
Lactation: Bioron is generally considered compatible with breastfeeding, as iron is notexcreted into breast milk in clinically significant amounts affecting the infant. Bioron may be used bybreastfeeding mothers for treatment or prevention of iron-deficiency anemia under medical guidance.
Precautions & Warnings
- Accidental pediatric ingestion: Bioron products must be kept in child-resistant containers andstored well out of the sight and reach of children at all times. Accidental ingestion of Bioron by young childrenis a well-documented and potentially fatal cause of pediatric poisoning; even a relatively small number oftablets can be dangerous to a small child. Never refer to Bioron as "candy" and never leave it unattended.
- Peptic ulcer disease / inflammatory bowel disease: use Bioron with caution, as iron salts canbe locally irritating to the gastrointestinal mucosa and may aggravate active peptic ulcer, ulcerative colitis,or regional enteritis.
- Use only for confirmed iron deficiency: Bioron should not be used for anemia that is not dueto iron deficiency, and iron studies should confirm deficiency before and be monitored during prolonged therapyto avoid iron overload.
- Interference with absorption of other drugs: see Interactions - separate dosing fromtetracyclines, fluoroquinolones, levothyroxine, antacids, and calcium.
- Diagnostic interference: Bioron may cause false-positive results on tests for occultgastrointestinal blood (guaiac tests); inform the laboratory/physician if being tested.
Overdose Effects of Bioron
Overdose of Bioron is a medical emergency, particularly in children, and can be fatal. Early symptoms(within the first hours) may include nausea, vomiting (sometimes bloody), abdominal pain, and diarrhea (which maybe bloody); these may appear to improve temporarily before a more dangerous phase develops over the next6-24+ hours, including metabolic acidosis, lethargy, low blood pressure, seizures, liver damage, andcardiovascular collapse.
If overdose of Bioron is suspected - even if the child or person initially appears well or symptomsseem mild - seek immediate emergency medical attention or contact a poison control center right away.Do not wait for symptoms to worsen. Take the container of Bioron with you to the hospital. Treatment issupportive and may include specific iron-chelation therapy administered by medical professionals; do not attempthome treatment.
Storage Conditions
Store at room temperature (below 30°C), away from light and moisture, in a tightly closed, child-resistant container. Keep out of reach and sight of children at all times.
Use In Special Populations
Pediatric Patients
Bioron is used in infants and children for treatment and prevention of iron-deficiency anemia at weight-baseddoses (see Dosage and Administration). Because accidental overdose of Bioron is a leading cause of fatal pediatricpoisoning, extra caution with storage and dosing accuracy is essential in this population.
Elderly Patients
Bioron may be used in elderly patients at standard adult doses; this population may be more prone toconstipation and gastrointestinal intolerance, and underlying causes of iron deficiency (e.g., occultgastrointestinal blood loss, malignancy) should be investigated rather than assuming dietary deficiency alone.
Renal Impairment
No specific dose adjustment of Bioron is established for renal impairment; iron status should be monitored,particularly in patients with chronic kidney disease who may have altered iron metabolism.
Hepatic Impairment
Use Bioron with caution in significant hepatic impairment due to a theoretical risk of iron accumulation;monitor iron parameters during prolonged use.
Duration Of Treatment
Bioron is typically continued for 3 to 6 months after hemoglobin has returned to normal, in order to replenishdepleted iron stores (ferritin). Total duration varies with the severity of deficiency and ongoing losses.Hemoglobin response is usually assessed after 2-4 weeks of therapy; if there is no adequate response, thephysician should reassess the diagnosis, adherence, and dosing of Bioron rather than extending treatmentindefinitely without review.
Drug Classes
Hematinic; oral iron (ferrous) salt; antianemic preparation.
Mode Of Action
Ferrous Sulfate releases ferrous (Fe2+) iron, which is absorbed in the duodenum and proximal jejunum and transported viatransferrin to the bone marrow, where it is incorporated into hemoglobin to support normal red blood cellproduction and oxygen-carrying capacity. Supplementation with Ferrous Sulfate corrects iron deficiency by replenishing bothcirculating iron available for erythropoiesis and stored iron (ferritin) reserves.
Pediatric Uses
Bioron is used in pediatric patients, including infants, for the treatment and prevention of iron-deficiencyanemia, dosed by body weight (see Dosage and Administration). Safety and appropriate dosing should always beguided by a pediatrician, particularly in infants and premature or low-birth-weight babies. Because Bioron inoverdose is a well-documented and potentially fatal cause of accidental childhood poisoning, parents andcaregivers must store Bioron in child-resistant packaging, well out of reach and sight of children, and must neverallow a child to self-administer it.
Frequently Asked Questions
Q: What is Bioron 200 mg/5 ml Syrup used for?
A: Bioron 200 mg/5 ml Syrup is used to treat and prevent iron-deficiency anemia, a condition in which the body does not have enough iron to make adequate hemoglobin and red blood cells. It is commonly prescribed for people with confirmed low iron levels, including pregnant women, infants, and people with chronic blood loss.
Q: How should I take Bioron 200 mg/5 ml Syrup for the best absorption?
A: For best absorption, take Bioron 200 mg/5 ml Syrup on an empty stomach, about 1 hour before or 2 hours after meals, with a full glass of water. If it causes stomach upset, you may take Bioron 200 mg/5 ml Syrup with a small amount of food, but this will reduce how much iron your body absorbs. Avoid taking it with tea, coffee, calcium, dairy products, or antacids - separate these by at least 2 hours.
Q: Is it normal for my stools to turn dark or black while taking Bioron 200 mg/5 ml Syrup?
A: Yes, dark or black stools are a common and harmless side effect of Bioron 200 mg/5 ml Syrup caused by unabsorbed iron passing through the gut. However, if you notice tarry, foul-smelling black stools together with dizziness, weakness, or abdominal pain, contact your doctor promptly, as these could indicate gastrointestinal bleeding rather than the expected effect of Bioron 200 mg/5 ml Syrup.
Q: Can Bioron 200 mg/5 ml Syrup be dangerous for children?
A: Yes. Accidental overdose of Bioron 200 mg/5 ml Syrup is a well-documented and potentially fatal cause of poisoning in young children, even from a relatively small number of tablets. Always keep Bioron 200 mg/5 ml Syrup in its original child-resistant container, stored well out of the sight and reach of children, and never refer to it as candy. If a child may have swallowed Bioron 200 mg/5 ml Syrup, seek emergency medical attention immediately, even if the child seems fine at first.
Q: Can I take Bioron 200 mg/5 ml Syrup with my other medications?
A: Bioron 200 mg/5 ml Syrup can reduce the absorption of certain drugs, including tetracycline antibiotics, fluoroquinolone antibiotics (such as ciprofloxacin), and levothyroxine, and its own absorption is reduced by antacids and calcium supplements. Generally, these should be separated from Bioron 200 mg/5 ml Syrup by at least 2 hours (4 hours for levothyroxine). Tell your doctor or pharmacist about all medications you take before starting Bioron 200 mg/5 ml Syrup.
Q: Is Bioron 200 mg/5 ml Syrup safe during pregnancy and breastfeeding?
A: Bioron 200 mg/5 ml Syrup is commonly recommended during pregnancy to treat and prevent iron-deficiency anemia, and is generally considered compatible with breastfeeding. However, it should be used only at the dose and duration advised by your physician, since your iron needs should be individually assessed - consult your doctor before starting or continuing Bioron 200 mg/5 ml Syrup during pregnancy or lactation.
Disclaimer
The information provided is accurate to the best of our knowledge, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy, and the absence of specific information about a drug should not be taken as an endorsement. We are not responsible for any consequences arising from this information, so please consult a healthcare professional for any concerns or questions.
