Butapan20 mg

Hyoscine butylbromide is used to relieve painful spasms of smooth muscle in the digestive and genitourinary systems.

• Abdominal cramping and pain associated with irritable bowel syndrome (IBS)
• Spasm of the gastrointestinal tract, including biliary and renal colic
• Spasm of the genitourinary tract
• As an adjunct to reduce gut motility during certain diagnostic procedures, when used by injection under medical supervision

Contains Butapan 20 mg (also known as scopolamine butylbromide) as the active ingredient. It is available as oral tablets (commonly 10 or 20 mg) and as an injection (commonly 20 mg/mL). Exact strengths and available forms may vary by product.

Hyoscine butylbromide is an antispasmodic (anticholinergic) medicine used to relieve painful cramping and spasm in the stomach, intestines, and urinary tract. It works by relaxing smooth muscle in these organs and, unlike some related anticholinergic drugs, does not readily cross into the brain, so it causes fewer central nervous system side effects. It is available as tablets for milder, ongoing symptoms and as an injection for rapid relief of acute spasm.

Therapeutic Class: Antispasmodic (Gastrointestinal and genitourinary smooth muscle relaxant)

As a quaternary ammonium compound, Butapan 20 mg has low lipid solubility and does not readily cross the blood-brain barrier, which limits central anticholinergic effects compared to atropine or hyoscine hydrobromide. It acts predominantly on peripheral muscarinic receptors in smooth muscle and, to a lesser degree, has ganglion-blocking properties at higher doses. It is mainly eliminated via the kidneys.

Tablets are usually taken with water; they may be taken with or without food, as directed by the prescriber. The injectable form is given by intramuscular, subcutaneous, or intravenous route by a healthcare professional; intramuscular injection should be avoided in patients on anticoagulant therapy because of the risk of intramuscular hematoma, and the subcutaneous or intravenous route may be used instead in such patients.

Hyoscine butylbromide may have increased anticholinergic effects when combined with other drugs that have anticholinergic properties, including:

• Tricyclic antidepressants
• Certain antihistamines
• Phenothiazines and butyrophenones (antipsychotics)
• Amantadine, quinidine, and disopyramide

Combining these medicines may increase side effects such as dry mouth, blurred vision, or urinary retention, and should be assessed by a healthcare professional. Alcohol may increase drowsiness and should generally be avoided while using this medicine.

Common side effects

• Dry mouth
• Constipation
• Dizziness
• Tachycardia (fast heartbeat)
• Disturbances of visual accommodation (temporary blurred vision)
• Urinary retention or hesitancy

Less common side effects

• Skin rash or itching
• Swelling of the hands or feet
• Diarrhea

Seek prompt medical attention for signs of an allergic reaction (swelling of the face, lips, or throat, difficulty breathing) or severe eye pain with visual disturbance.

Pregnancy

Data on the use of Butapan 20 mg in pregnant women is limited. Animal studies have not shown direct or indirect harmful effects on reproduction, but human safety data are insufficient. It should be used in pregnancy only if considered clearly necessary by a doctor.

Breastfeeding

It is not established whether Butapan 20 mg passes into breast milk in clinically significant amounts. Use during breastfeeding should only occur if advised by a healthcare professional.

• Use with caution in patients susceptible to narrow-angle glaucoma or with intestinal or urinary outlet obstruction, due to the risk of anticholinergic complications.
• Use with caution in patients prone to tachyarrhythmia.
• Hyoscine butylbromide may cause drowsiness or visual disturbance; patients affected should avoid driving or operating machinery until symptoms resolve.
• Patients should avoid excessive alcohol intake while using this medicine.
• Intramuscular injection is contraindicated in patients on anticoagulant therapy due to the risk of hematoma at the injection site; the subcutaneous or intravenous route may be considered instead.

Overdose can cause exaggerated anticholinergic effects, such as marked dry mouth, blurred vision, difficulty urinating, rapid heartbeat, flushing, and in more severe cases, agitation or breathing difficulty. Suspected overdose, especially involving the injectable form, requires prompt medical attention; treatment is generally supportive and provided in a medical facility.

Store Butapan 20 mg injection protected from light and heat, and protect from freezing; typically stored at 15-30°C. Oral tablets should be stored at room temperature, away from moisture and excess heat. Exact storage conditions may vary by product and formulation; always follow the specific product's packaging instructions.

• Elderly: May be more sensitive to anticholinergic effects such as urinary retention, constipation, and visual disturbance; use with caution.
• Renal impairment: Hyoscine butylbromide is largely eliminated by the kidneys; use with caution, as reduced clearance may increase drug effects.
• Hepatic impairment: Metabolism is minimal, but caution is advised in significant hepatic disease.

Treatment duration depends on the underlying cause of the spasm and clinical response. For chronic or recurrent conditions such as IBS, use may continue intermittently as needed under medical guidance. If symptoms persist beyond a few days despite treatment, or recur frequently, medical review is recommended to reassess the underlying cause.

Drug Class: Anticholinergic / antimuscarinic agent (quaternary ammonium compound)

Hyoscine butylbromide blocks muscarinic acetylcholine receptors on smooth muscle in the gastrointestinal, biliary, and genitourinary tracts. By preventing acetylcholine from stimulating these receptors, it relaxes the smooth muscle, reducing spasm and the pain caused by cramping contractions.

The injectable form of Butapan 20 mg is not recommended for use in children according to some manufacturer prescribing information. Oral use in children should only be undertaken on a physician's advice, with dosing individualized to the child's age and weight; parents should not give this medicine to children without professional guidance.