Cefalex

Cefalex125 mg/5 ml

Powder for Suspension

Cephalexin

Drug International Ltd.

Product Code : 3029
MRP 80.97
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Medicine overview

Indications of Cefalex 125 mg/5 ml

Cefalex 125 mg/5 ml is indicated for the treatment of the following infections when caused by susceptible organisms. Respiratory tract infections: Acute and chronic bronchitis and infected bronchiectasis. Genito-urinary tract infections: Acute and chronic nephritis, cystitis, urethritis and prostatitis, prophylaxis of recurrent urinary tract infections. ... Read moreCefalex 125 mg/5 ml is indicated for the treatment of the following infections when caused by susceptible organisms. Respiratory tract infections: Acute and chronic bronchitis and infected bronchiectasis. Genito-urinary tract infections: Acute and chronic nephritis, cystitis, urethritis and prostatitis, prophylaxis of recurrent urinary tract infections. Skin and soft tissue infections: Caused by staphylococci and/or streptococci. Ear, Nose and Throat infections: Otitis media, mastoiditis, sinusitis, follicular tonsillitis and pharyngitis. Bone infections: Caused by staphylococci and/or P. mirabilis.

Theropeutic Class

First generation Cephalosporins

Pharmacology

Cefalex 125 mg/5 ml is a semisynthetic analogue of Cephalosporin C. It kills bacteria by interfering in the synthesis of the bacterial cell wall. Peptidoglycan is a heteropolymeric structure that provides the cell wall with mechanical stability. The final stage in the synthesis of peptidoglycan involves the completion of the cross-linking and the terminal glycine residue of the Pentaglycine Bridge is linked to the fourth residue of the pentapeptide (d-alanin). The transpeptidase enzyme that performs this step is inhibited by penicillins and cephalosporins. As a result the bacterial cell wall is weakened, the cell swells and then ruptures. Cefalex 125 mg/5 ml is a first generation cephalosporin that is active by mouth.

Dosage & Administration of Cefalex 125 mg/5 ml

Adult: The usual dose is 250 mg to 500 mg every 6 hour. For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily. Children: The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g dailyChildren's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour. In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days.

Dosage of Cefalex 125 mg/5 ml

Adult: The usual dose is 250 mg to 500 mg every 6 hour. For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily. Children: The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g dailyChildren's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour. In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days.

Contraindications

Cephalen is contraindicated in patients with known hypersensitivity to the cephalosporin group of antibiotics.

Side Effects of Cefalex 125 mg/5 ml

Side effects include nausea, vomiting, diarrhoea and abdominal discomfort. Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Skin rash, angio oedema, rise in serum aminotransferases, eosinophilia, neutropenia have been reported very rarely. Superinfection with resistant micro organisms, particularly candida may follow the treatment.

Pregnancy & Lactation

Pregnancy Category B. Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.

Precautions & Warnings

Cefalexin should be given with caution in patients with renal impairment. Under such condition, careful clinical observation should be made because safe dosage may be lower than the usually recommended. The urine of patients receiving Cefalexin may give a false positive reaction for glucose with copper reduction reagent. Positive results to Coombs’ test have been reported. Although there is no evidence of teratogenicity in animal tests, Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.

Storage Conditions

Should be stored in cool and dry place.

Drug Classes

First generation Cephalosporins

Mode Of Action

Cefalex 125 mg/5 ml is a semisynthetic analogue of Cephalosporin C. It kills bacteria by interfering in the synthesis of the bacterial cell wall. Peptidoglycan is a heteropolymeric structure that provides the cell wall with mechanical stability. The final stage in the synthesis of peptidoglycan involves the completion of the cross-linking and the terminal glycine residue of the Pentaglycine Bridge is linked to the fourth residue of the pentapeptide (d-alanin). The transpeptidase enzyme that performs this step is inhibited by penicillins and cephalosporins. As a result the bacterial cell wall is weakened, the cell swells and then ruptures. Cefalex 125 mg/5 ml is a first generation cephalosporin that is active by mouth.

Pregnancy

Pregnancy Category B. Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.