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Cefalex500 mg
Drug International Ltd.
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Ceflex500 mg
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Medicine overview
Indications of Ceflex 500 mg
cystitisurethritis and prostatitiscystitisurethritis and prostatitisNose and Throat infections: Otitis mediamastoiditissinusitisfollicular tonsillitis and pharyngitis. Bone infections: Caused by staphylococci and/or P. mirabilis.
Theropeutic Class
First generation Cephalosporins
Pharmacology
Ceflex 500 mg is a semisynthetic analogue of Cephalosporin C.
Absorption
It kills bacteria by interfering in the synthesis of the bacterial cell wall. Peptidoglycan is a heteropolymeric structure that provides the cell wall with mechanical stability.
Distribution
The final stage in the synthesis of peptidoglycan involves the completion of the cross-linking and the terminal glycine residue of the Pentaglycine Bridge is linked to the fourth residue of the pentapeptide (d-alanin). The transpeptidase enzyme that performs this step is inhibited by penicillins and cephalosporins.
Metabolism
As a result the bacterial cell wall is weakened, the cell swells and then ruptures. Ceflex 500 mg is a first generation cephalosporin that is active by mouth.
Dosage & Administration of Ceflex 500 mg
Adult
Dosage:The usual dose is 250 mg to 500 mg every 6 hour
Notes:For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily
Children
Dosage:The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g dailyChildren's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour
Notes:In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days
| Condition | Dosage | Notes |
|---|---|---|
| Adult | The usual dose is 250 mg to 500 mg every 6 hour | For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily |
| Children | The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g dailyChildren's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour | In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days |
Dosage of Ceflex 500 mg
Adult
Dosage:The usual dose is 250 mg to 500 mg every 6 hour
Notes:For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily
Children
Dosage:The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g dailyChildren's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour
Notes:In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days
| Condition | Dosage | Notes |
|---|---|---|
| Adult | The usual dose is 250 mg to 500 mg every 6 hour | For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily |
| Children | The dosage range is 25-100 mg/kg/day in divided doses to a maximum of 4 g dailyChildren's Weight Recommended Dose: 10 kg (22 Ibs): 62.5 mg to 125 mg qid or 125 mg to 250 mg bid 20 kg (44 Ibs): 125 mg to 250 mg qid or 250 mg to 500 mg bid 40 kg (88 Ibs): 250 mg to 500 mg qid or 500 mg to 1 g bid For streptococcal pharyngitis, skin and soft tissue infections and in patients over 1 year of age the total daily dose may be divided and administered every 12 hour | In the therapy of otitis media 75-100 mg/kg/day in four divided doses may be required. In the treatment of β haemolytic streptococcal infections a therapeutic dosage of the drug should be given at least for 10 days |
Contraindications
Cephalen is contraindicated in patients with known hypersensitivity to the cephalosporin group of antibiotics.
Side Effects of Ceflex 500 mg
Side effects include nausea, vomiting, diarrhoea and abdominal discomfort. Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Skin rash, angio oedema, rise in serum aminotransferases, eosinophilia, neutropenia have been reported very rarely. Superinfection with resistant micro organisms, particularly candida may follow the treatment.
Pregnancy & Lactation
Pregnancy Category B. Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.
Precautions & Warnings
Cefalexin should be given with caution in patients with renal impairment. Under such condition, careful clinical observation should be made because safe dosage may be lower than the usually recommended. The urine of patients receiving Cefalexin may give a false positive reaction for glucose with copper reduction reagent. Positive results to Coombs’ test have been reported. Although there is no evidence of teratogenicity in animal tests, Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.
Storage Conditions
Should be stored in cool and dry place.
Drug Classes
First generation Cephalosporins
Mode Of Action
Ceflex 500 mg is a semisynthetic analogue of Cephalosporin C. It kills bacteria by interfering in the synthesis of the bacterial cell wall. Peptidoglycan is a heteropolymeric structure that provides the cell wall with mechanical stability. The final stage in the synthesis of peptidoglycan involves the completion of the cross-linking and the terminal glycine residue of the Pentaglycine Bridge is linked to the fourth residue of the pentapeptide (d-alanin). The transpeptidase enzyme that performs this step is inhibited by penicillins and cephalosporins. As a result the bacterial cell wall is weakened, the cell swells and then ruptures. Ceflex 500 mg is a first generation cephalosporin that is active by mouth.
Pregnancy
Pregnancy Category B. Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.
Frequently Asked Questions
What is Ceflex 500 mg used for?
Cephalexin is indicated for the treatment of the following infections when caused by susceptible organisms. Respiratory tract infections: Acute and chronic bronchitis and infected bronchiectasis. Genito-urinary tract infections: Acute and chronic nephritis, cystitis, urethritis and prostatitis, prophylaxis of recurrent urinary tract infections. ... Read moreCephalexin is indicated for the treatmen…
What is the dosage of Ceflex 500 mg?
Adult: The usual dose is 250 mg to 500 mg every 6 hour. For skin and soft tissue infections, streptococcal pharyngitis and uncomplicated cystitis, in patients over 15 years of age: 500 mg of the drug may be administered every 12 hour. In severe or deep seated infections the dose can be increased up to 3 g to 6 g daily. Children: The dosage range is 25-100 mg/kg/day in divided doses to a maximum of…
What are the side effects of Ceflex 500 mg?
Side effects include nausea, vomiting, diarrhoea and abdominal discomfort. Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Skin rash, angio oedema, rise in serum aminotransferases, eosinophilia, neutropenia have been reported very rarely. Superinfection with resistant micro organisms, particularly candida may follow the treatment.
Who should not take Ceflex 500 mg?
Cephalen is contraindicated in patients with known hypersensitivity to the cephalosporin group of antibiotics.
What precautions should be taken with Ceflex 500 mg?
Cefalexin should be given with caution in patients with renal impairment. Under such condition, careful clinical observation should be made because safe dosage may be lower than the usually recommended. The urine of patients receiving Cefalexin may give a false positive reaction for glucose with copper reduction reagent. Positive results to Coombs’ test have been reported. Although there is no evi…
Is Ceflex 500 mg safe during pregnancy and breastfeeding?
Pregnancy Category B. Cefalexin may be used during pregnancy when it is considered essential. Cefalexin is found in the milk of nursing mothers, hence caution should be taken when it is administered to nursing mothers.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.