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Ceftax250 mg/5 ml
IM/IV Injection
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Medicine overview
Indications of Ceftax 250 mg/5 ml
bacterial pneumoniabacterial pneumoniainfected bronchiectasislung abscess and postoperative chest infections Urinary Tract Infections such as acute and chronic pyelonephritiscystitis and asymptomatic bacteriuria Soft-tissue Infection such as cellulitisperitonitis and wound infections Bone and Joint Infections such as osteomyelitis
Theropeutic Class
Third generation Cephalosporins
Pharmacology
Ceftax 250 mg/5 ml binds to 1 or more of the penicillin binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption
Ceftax 250 mg/5 ml is a broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic.
Distribution
Ceftax 250 mg/5 ml is exceptionally active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins.
Metabolism
It is similar to other cephalosporins in activity against gram-positive bacteria.
Dosage & Administration of Ceftax 250 mg/5 ml
Adults
Dosage:The recommended dosage for mild to moderate infections is 1 gm every 12 hourly
Notes:However, dosage may be varied according to the severity of infection, sensitivity of causative organisms and condition of the patient. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. For infections caused by sensitive Pseudomonas spp. daily doses of greater than 6 gm will usually be requiredChildren: The usual dosage range is 100-150 mg/kg/day in 2 to 4 divided doses. However, in very severe infections doses of up to 200 mg/kg/day may be required
Neonates
Dosage:The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses
Notes:In severe infections 150-200 mg/kg/day, in divided doses, have been given
Dosage in gonorrhoea
Dosage:500 mg as a single dose
| Condition | Dosage | Notes |
|---|---|---|
| Adults | The recommended dosage for mild to moderate infections is 1 gm every 12 hourly | However, dosage may be varied according to the severity of infection, sensitivity of causative organisms and condition of the patient. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. For infections caused by sensitive Pseudomonas spp. daily doses of greater than 6 gm will usually be requiredChildren: The usual dosage range is 100-150 mg/kg/day in 2 to 4 divided doses. However, in very severe infections doses of up to 200 mg/kg/day may be required |
| Neonates | The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses | In severe infections 150-200 mg/kg/day, in divided doses, have been given |
| Dosage in gonorrhoea | 500 mg as a single dose |
Dosage of Ceftax 250 mg/5 ml
Adults
Dosage:The recommended dosage for mild to moderate infections is 1 gm every 12 hourly
Notes:However, dosage may be varied according to the severity of infection, sensitivity of causative organisms and condition of the patient. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. For infections caused by sensitive Pseudomonas spp. daily doses of greater than 6 gm will usually be requiredChildren: The usual dosage range is 100-150 mg/kg/day in 2 to 4 divided doses. However, in very severe infections doses of up to 200 mg/kg/day may be required
Neonates
Dosage:The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses
Notes:In severe infections 150-200 mg/kg/day, in divided doses, have been given
Dosage in gonorrhoea
Dosage:500 mg as a single dose
| Condition | Dosage | Notes |
|---|---|---|
| Adults | The recommended dosage for mild to moderate infections is 1 gm every 12 hourly | However, dosage may be varied according to the severity of infection, sensitivity of causative organisms and condition of the patient. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. For infections caused by sensitive Pseudomonas spp. daily doses of greater than 6 gm will usually be requiredChildren: The usual dosage range is 100-150 mg/kg/day in 2 to 4 divided doses. However, in very severe infections doses of up to 200 mg/kg/day may be required |
| Neonates | The recommended dosage is 50 mg/kg/day in 2 to 4 divided doses | In severe infections 150-200 mg/kg/day, in divided doses, have been given |
| Dosage in gonorrhoea | 500 mg as a single dose |
Interaction of Ceftax 250 mg/5 ml
Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.
Contraindications
Ceftax 250 mg/5 ml is contraindicated in patients who have shown hypersensitivity to Ceftax 250 mg/5 ml or the cephalosporin group of antibiotics.
Side Effects of Ceftax 250 mg/5 ml
Adverse reactions to Ceftax 250 mg/5 ml have occurred relatively infrequently and have generally been mild and transient. Effects reported include candidiasis, rashes, fever, transient rises in liver transaminase and/or alkaline phosphatase and diarrhoea. As with all cephalosporins, pseudomembranous colitis may rarely occur during treatment. If this occurs the drug should be stopped and specific treatment instituted.As with other cephalosporins, changes in renal function have been rarely observed with high doses of Ceftax 250 mg/5 ml. Administration of high doses of cephalosporins particularly in patients with renal insufficiency may result in encephalopathy. Hypersensitivity reactions have been reported, these include skin rashes, drug fever and very rarely anaphylaxis.
Pregnancy & Lactation
Although studies in animals have not shown any adverse effect on the developing foetus, the safety of Ceftax 250 mg/5 ml in human pregnancy has not been established. Consequently, Ceftax 250 mg/5 ml should not be administered during pregnancy especially during first trimester, without carefully weighing the expected benefit against possible risks. Ceftax 250 mg/5 ml is excreted in the milk.
Precautions & Warnings
Ceftax 250 mg/5 ml should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Because high and prolonged antibiotic concentrations can occur from usual doses in patients with transient or persistent reduction of urinary output because of renal insufficiency, the total daily dosage should be reduced when Ceftax 250 mg/5 ml is administered to such patients. Continued dosage should be determined by degree of renal impairment, severity of infection, and susceptibility of the causative organism. There is no clinical evidence supporting the necessity of changing the dosage of Ceftax 250 mg/5 ml in patients with even profound renal dysfunction.
Storage Conditions
Store below 25°C, protected from light and moisture. Use reconstituted solution immediately. Reconstituted solution is stable for up to 24 h if stored between 2° to 8°C.
Use In Special Populations
Dosage in renal impairment: Because of extra-renal elimination, it is only necessary to reduce the dosage of Ceftax 250 mg/5 ml in severe renal failure (GFR<5 ml/min = serum creatinine approximately 751 micromol/litre). After an initial loading dose of 1 gm, daily dose should be halved without change in the frequency of dosing. In all other patients, dosage may require further adjustment according to the course of infection and the general condition of the patient.
Drug Classes
Third generation Cephalosporins
Mode Of Action
Ceftax 250 mg/5 ml binds to 1 or more of the penicillin binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Ceftax 250 mg/5 ml is a broad spectrum bactericidal 3rd generation parenteral cephalosporin antibiotic. Ceftax 250 mg/5 ml is exceptionally active against gram-negative organisms sensitive or resistant to first or second generation cephalosporins. It is similar to other cephalosporins in activity against gram-positive bacteria.
Pregnancy
Although studies in animals have not shown any adverse effect on the developing foetus, the safety of Ceftax 250 mg/5 ml in human pregnancy has not been established. Consequently, Ceftax 250 mg/5 ml should not be administered during pregnancy especially during first trimester, without carefully weighing the expected benefit against possible risks. Ceftax 250 mg/5 ml is excreted in the milk.
Pediatric Uses
Dosage in renal impairment: Because of extra-renal elimination, it is only necessary to reduce the dosage of Ceftax 250 mg/5 ml in severe renal failure (GFR<5 ml/min = serum creatinine approximately 751 micromol/litre). After an initial loading dose of 1 gm, daily dose should be halved without change in the frequency of dosing. In all other patients, dosage may require further adjustment according to the course of infection and the general condition of the patient.
Frequently Asked Questions
What is Ceftax 250 mg/5 ml used for?
Cefotaxime is indicated for the treatment of the following infections either before the infecting organism has been identified or when caused by bacteria of established sensitivity: Septicaemia Respiratory Tract Infections such as acute or chronic bronchitis, bacterial pneumonia, infected bronchiectasis ... Read moreCefotaxime is indicated for the treatment of the following infections either befor…
What is the dosage of Ceftax 250 mg/5 ml?
Adults: The recommended dosage for mild to moderate infections is 1 gm every 12 hourly. However, dosage may be varied according to the severity of infection, sensitivity of causative organisms and condition of the patient. In severe infections dosage may be increased up to 12 gm daily given in 3 or 4 divided doses. For infections caused by sensitive Pseudomonas spp. daily doses of greater than 6 g…
What are the side effects of Ceftax 250 mg/5 ml?
Adverse reactions to Cefotaxime have occurred relatively infrequently and have generally been mild and transient. Effects reported include candidiasis, rashes, fever, transient rises in liver transaminase and/or alkaline phosphatase and diarrhoea. As with all cephalosporins, pseudomembranous colitis may rarely occur during treatment. If this occurs the drug should be stopped and specific treatment…
Who should not take Ceftax 250 mg/5 ml?
Cefotaxime is contraindicated in patients who have shown hypersensitivity to cefotaxime or the cephalosporin group of antibiotics.
What precautions should be taken with Ceftax 250 mg/5 ml?
Cefotaxime should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Because high and prolonged antibiotic concentrations can occur from usual doses in patients with transient or persistent reduction of urinary output because of renal insufficiency, the total daily dosage should be reduced when Cefotaxime is administered to such patients. Co…
Is Ceftax 250 mg/5 ml safe during pregnancy and breastfeeding?
Although studies in animals have not shown any adverse effect on the developing foetus, the safety of Cefotaxime in human pregnancy has not been established. Consequently, Cefotaxime should not be administered during pregnancy especially during first trimester, without carefully weighing the expected benefit against possible risks. Cefotaxime is excreted in the milk.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.