Cinekar

Cinekar5 mg

Tablet

Cilnidipine

Julphar Bangladesh Ltd.

Product Code : 3506
MRP 7.00
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Medicine overview

Indications of Cinekar 5 mg

Cinekar 5 mg is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cinekar 5 mg has been increasingly used in patients with chronic kidney diseaseHypertension is the term used to ... Read moreCinekar 5 mg is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cinekar 5 mg has been increasingly used in patients with chronic kidney diseaseHypertension is the term used to describe the presence of high blood pressure. The blood pressure is generated by the force of the blood pumped from the heart against the blood vessels. Thus hypertension is caused when there is too much pressure on the blood vessels and this effect can damage the blood vessel

Theropeutic Class

Calcium-channel blockers

Pharmacology

Cinekar 5 mg is a dihydropyridine calcium-channel blocker. Cinekar 5 mg binds to the dihydropy-ridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells via this channel, consequently vascular smooth muscle is relaxed, causing vasodilation. Cinekar 5 mg inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane. The inhibition of Ca2+ influx via N-type voltage dependent calcium channel was observed over a similar range of drug concentrations to those inhibiting L-type voltage dependent Ca2+ channels. Consequently, release of norepinephrine from sympathetic nerve terminals would be inhibited. Cinekar 5 mg is considered to suppress the reflex increase in heart rate after blood pressure reduction.

Dosage & Administration of Cinekar 5 mg

Adults: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily. The safety of Cinekar 5 mg in pediatric patients has not been established.Use in the elderly: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).

Dosage of Cinekar 5 mg

Adults: 5-10 mg once daily after breakfast. Maximum dose: 20 mg once daily. Pediatric use: The safety of Cinekar 5 mg in pediatric patients has not been established.Elderly use: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose (5 mg).

Interaction of Cinekar 5 mg

Other anti-hypertensive, antipsychotics that cause hypotension, quinidine, carbamazepine, phenytoin, rifampicin, cimetidine, erythromycin.

Contraindications

Cinekar 5 mg is contraindicated in patients with known sensitivity to Cinekar 5 mg or any of the excipients or patients having cardiogenic shock, recent MI or acute unstable angina and severe aortic stenosis.

Side Effects of Cinekar 5 mg

The most common side effects of Cinekar 5 mg are: Dizziness; flushing; headache; hypotension; peripheral oedema; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression.

Pregnancy & Lactation

Cinekar 5 mg should not be administered in pregnant woman or woman having possibilities of being pregnant. It is also advisable to avoid the administration of Cinekar 5 mg to nursing mothers. However, if the administration is indispensable, the patient should be instructed to discontinue lactation.

Precautions & Warnings

Cinekar 5 mg should be administered with care in the following patients: patients with serious hepatic dysfunction, patients with a history of serious adverse reactions to calcium antagonists. During the discontinuation, the dosage should be gradually decreased under close observation.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep away from reach out of the children.

Drug Classes

Calcium-channel blockers

Mode Of Action

Cinekar 5 mg is a dihydropyridine calcium-channel blocker. Cinekar 5 mg binds to the dihydropy-ridine binding sites of the L-type voltage dependent calcium channel and inhibits Ca2+ influx across the cell membranes of vascular smooth muscle cells via this channel, consequently vascular smooth muscle is relaxed, causing vasodilation. Cinekar 5 mg inhibits Ca2+ influx via N-type voltage dependent calcium channels in the sympathetic nerve cell membrane. The inhibition of Ca2+ influx via N-type voltage dependent calcium channel was observed over a similar range of drug concentrations to those inhibiting L-type voltage dependent Ca2+ channels. Consequently, release of norepinephrine from sympathetic nerve terminals would be inhibited. Cinekar 5 mg is considered to suppress the reflex increase in heart rate after blood pressure reduction.

Pregnancy

Cinekar 5 mg should not be administered in pregnant woman or woman having possibilities of being pregnant. It is also advisable to avoid the administration of Cinekar 5 mg to nursing mothers. However, if the administration is indispensable, the patient should be instructed to discontinue lactation.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.