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Clozosone0.05%+1%
Cream
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Medicine overview
Indications of Clozosone 0.05%+1%
This topical preparation is indicated for the topical treatment of inflammatory dermal infections like-
Tinea pedis
Tinea cruris
Tinea corporis etc.
Theropeutic Class
Betamethasone & Combined preparations
Pharmacology
Clotrimazole is a broad-spectrum antifungal agent used for the treatment of superficial infections caused by species of pathogenic dermatophytes, yeasts and Malassezia furfur.
Absorption
The mechanism of action involves inhibition of the synthesis of ergosterol, a major sterol in the fungal cell membrane.
Distribution
This leads to instability of the cell membrane and eventual death of the fungus.
Metabolism
Betamethasone dipropionate is a corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties.
Excretion
But the exact mechanism of action of corticosteroids is not clearly known.
Dosage & Administration of Clozosone 0.05%+1%
Sufficient cream or ointment should be applied onto the affected and surrounding skin areas twice a day, in the morning and evening, for 2 weeks in tinea cruris and tinea corporis and for 4 weeks in tinea pedis. The use of cream for longer than four weeks is not recommended.
Dosage of Clozosone 0.05%+1%
Sufficient topical preparation should be applied onto the affected and surrounding skin areas twice a day, in the morning and evening, for 2 weeks in tinea cruris and tinea corporis and for 4 weeks in tinea pedis. The use of this cream for longer than four weeks is not recommended.The safety and effectiveness of the preparation have not been established in children below the age of 12 years.
Interaction of Clozosone 0.05%+1%
No information is available of drug interaction.
Contraindications
This topical preparation is contraindicated to those patients who are sensitive to any of its components or to other corticosteroids or to imidazoles. If irritation or sensitization develops with the use of the cream, treatment should be discontinued and appropriate therapy instituted. The cream is contraindicated in facial rosacea, acne vulgaris, perioral dermatits, perianal and genital pruritus, napkin eruptions and bacterial or viral infections. Systemic absorption of topical corticosteroides can produce reversible hypothalmic-pituitary-adrenal (HPA) axis suppression. If HPA axis suppression is noted, an attempt should be made to withdraw the drug or to reduce the frequency of application. Pediatric patients may be more susceptible to systemic toxicity from equivalent doses due to their large skin surface to body mass ratios.
Side Effects of Clozosone 0.05%+1%
Adverse reactions reported for the preparation in clinical trials were paresthesia in 1.9% of patients, rash, edema and secondary infection, each in less than 1% of patients. Other adverse reactions reported with the preparation were burning and dry skin in 1.6% of patients and stinging in less than 1% of patients
Pregnancy & Lactation
Pregnancy: Catagory C. In the first trimester of pregnancy, clotrimazole should be used only when it is essential for the welfare of the patient. Administration of clotrimazole to a small number of women in the 2nd and 3rd trimesters of pregnancy has produced no obvious untoward effect on the course of the pregnancy or on the fetus. Lactation: Although systemic absorption following topical or vaginal administration is low, caution should be exercised when clotrimazole is administered to nursing mothers as there is no information on whether or not clotrimazole is excreted in breast milk.
Precautions & Warnings
Not recommended for use in diaper dermatitis and under occlusion. Pregnancy and lactation. If irritation or sensitization develops with the use of the cream, treatment should be discontinued and appropriate therapy instituted.
Overdose Effects of Clozosone 0.05%+1%
Acute overdose with the cream is unlikely and would not be expected to lead to a life-threatening situation. The cream should not be used for longer than the prescribed time period.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Use In Special Populations
The safety and effectiveness of the preparation has not been established in children below the age of 12 years.
Drug Classes
Betamethasone & Combined preparations
Mode Of Action
Clotrimazole is a broad-spectrum antifungal agent used for the treatment of superficial infections caused by species of pathogenic dermatophytes, yeasts and Malassezia furfur. The mechanism of action involves inhibition of the synthesis of ergosterol, a major sterol in the fungal cell membrane. This leads to instability of the cell membrane and eventual death of the fungus. Betamethasone dipropionate is a corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. But the exact mechanism of action of corticosteroids is not clearly known.
Pregnancy
There is inadequate evidence of safety in pregnancy. Clotrimazole has no teratogenic effect in animals but is foetotoxic at high oral doses. Topical administration of corticosteroids to pregnant animals can cause abnormalities of fetal development. Hence the cream should only be used in pregnancy if the benefit justifies the potential risk to the fetus and such use should not be extensive,i.e. in large amounts or for long periods. It is not known whether the components of the preparation are excreted in human milk and therefore caution should be exercised when treating nursing mothers.
Frequently Asked Questions
What is Clozosone 0.05%+1% used for?
This topical preparation is indicated for the topical treatment of inflammatory dermal infections like- Tinea pedis Tinea cruris Tinea corporis etc.
What is the dosage of Clozosone 0.05%+1%?
Sufficient topical preparation should be applied onto the affected and surrounding skin areas twice a day, in the morning and evening, for 2 weeks in tinea cruris and tinea corporis and for 4 weeks in tinea pedis. The use of this cream for longer than four weeks is not recommended.The safety and effectiveness of the preparation have not been established in children below the age of 12 years.
What are the side effects of Clozosone 0.05%+1%?
Adverse reactions reported for the preparation in clinical trials were paresthesia in 1.9% of patients, rash, edema and secondary infection, each in less than 1% of patients. Other adverse reactions reported with the preparation were burning and dry skin in 1.6% of patients and stinging in less than 1% of patients
Who should not take Clozosone 0.05%+1%?
This topical preparation is contraindicated to those patients who are sensitive to any of its components or to other corticosteroids or to imidazoles. If irritation or sensitization develops with the use of the cream, treatment should be discontinued and appropriate therapy instituted. The cream is contraindicated in facial rosacea, acne vulgaris, perioral dermatits, perianal and genital pruritus,…
What precautions should be taken with Clozosone 0.05%+1%?
Not recommended for use in diaper dermatitis and under occlusion. Pregnancy and lactation. If irritation or sensitization develops with the use of the cream, treatment should be discontinued and appropriate therapy instituted.
Is Clozosone 0.05%+1% safe during pregnancy and breastfeeding?
Pregnancy: Catagory C. In the first trimester of pregnancy, clotrimazole should be used only when it is essential for the welfare of the patient. Administration of clotrimazole to a small number of women in the 2nd and 3rd trimesters of pregnancy has produced no obvious untoward effect on the course of the pregnancy or on the fetus. Lactation: Although systemic absorption following topical or vagi…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.