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Cefotil Plus500 mg+125
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Co-axet500 mg+125 mg
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Medicine overview
Indications of Co-axet 500 mg+125 mg
Co-axet 500 mg+125 mg is indicated for treating infections caused by sensitive bacteriaHaemophilus influenzaeMoraxella catarrhalis (beta-lactamase producing strains)including pneumoniacaused by Streptococcus pneumoniaeHaemophilus influenzae (including beta-lactamase-producing strains)Klebsiella spp.Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains)Streptococcus pyogenesHaemophilus influenzae (beta-lactamase negative strains)Streptococcus pneumoniaeE.coliHaemophilus influenzae (including ampicillin-resistant strains)and Klebsiella spp Meningitis caused by Streptococcus pneumoniaeHaemophilus influenzae (including ampicillin-resistant strains)Neisseria meningitidisand Staphylococcus aureus (penicillinase and non-penicillinase-producing strains) Switch therapy (injectable to oral)
Theropeutic Class
Second generation Cephalosporins
Pharmacology
Cefuroxime is a bactericidal second-generation cephalosporin antibiotic that effectively targets a wide range of susceptible Gram-positive and Gram-negative organisms, including numerous beta-lactamase producing strains.
Absorption
It works by disrupting bacterial cell wall synthesis through interference with the transpeptidation process.
Distribution
Clavulanic acid, a naturally derived beta-lactamase inhibitor produced by Streptomyces clavuligerus, shares a similar structure with beta-lactam antibiotics.
Metabolism
It irreversibly binds to beta-lactamase enzymes, rendering them inactive.
Excretion
Clavulanic acid provides Cefuroxime with protection against degradation by beta-lactamase enzymes, offering a solution for treating bacterial infections caused by beta-lactam-resistant bacteria.
Dosage of Co-axet 500 mg+125 mg
Notes:Adolescents and adults (13 years and older)- Pharyngitis/tonsillitis: 250 mg b. for 5-10 days Acute bacterial maxillary sinusitis: 250 mg b. for 10 days Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b. for 10 days Secondary bacterial infections of acute bronchitis: 250-500 mg b. for 5-10 days Uncomplicated skin and skin structure infections: 250-500 mg b. for 10 days Uncomplicated urinary tract infections: 250 mg b. for 7-10 days Uncomplicated Gonorrhoea: 1000 mg b
Single dose Community acquired pneumonia
Dosage:250-500 mg b
Notes:for 5-10 days MDR Typhoid Fever: 500 mg b. for 10-14 days Early Lyme disease: 500 mg b. for 20 days Paediatric Patients (3 months to 12 years)- Pharyngitis/Tonsillitis: 20 mg/kg/day b. d for 5-10 days Acute otitis media: 30 mg/kg/day b. d for 10 days Acute bacterial maxillary sinusitis: 30 mg/kg/day b. d for 10 days Impetigo: 30 mg/kg/day b. d for 10 days
| Condition | Dosage | Notes |
|---|---|---|
| Adolescents and adults (13 years and older)- Pharyngitis/tonsillitis: 250 mg b. for 5-10 days Acute bacterial maxillary sinusitis: 250 mg b. for 10 days Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b. for 10 days Secondary bacterial infections of acute bronchitis: 250-500 mg b. for 5-10 days Uncomplicated skin and skin structure infections: 250-500 mg b. for 10 days Uncomplicated urinary tract infections: 250 mg b. for 7-10 days Uncomplicated Gonorrhoea: 1000 mg b | ||
| Single dose Community acquired pneumonia | 250-500 mg b | for 5-10 days MDR Typhoid Fever: 500 mg b. for 10-14 days Early Lyme disease: 500 mg b. for 20 days Paediatric Patients (3 months to 12 years)- Pharyngitis/Tonsillitis: 20 mg/kg/day b. d for 5-10 days Acute otitis media: 30 mg/kg/day b. d for 10 days Acute bacterial maxillary sinusitis: 30 mg/kg/day b. d for 10 days Impetigo: 30 mg/kg/day b. d for 10 days |
Administration of Co-axet 500 mg+125 mg
Co-axet 500 mg+125 mg tablet may be taken without regard of food.
Interaction of Co-axet 500 mg+125 mg
When probenecid is administered concurrently with Cefuroxime-Clavulanic Acid, it significantly increases the area under the serum concentration-time curve by 50%. The use of medications that reduce gastric acidity may result in decreased bioavailability of Cefuroxime, potentially counteracting its postprandial absorption benefits.
Contraindications
Cefuroxime-Clavulanic Acid is contraindicated in patients with a known allergy to cephalosporins and in patients with Pseudomembranous Colitis.
Side Effects of Co-axet 500 mg+125 mg
Generally Co-axet 500 mg+125 mg is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.
Pregnancy & Lactation
While it's generally advisable to avoid antibiotics during the first trimester of pregnancy, Co-axet 500 mg+125 mg can be used safely in later stages to address urinary and other infections. It is excreted into breast milk in small amounts, but it's essential to consider the potential for sensitizing the infant.
Precautions & Warnings
Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.
Storage Conditions
Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.
Drug Classes
Second generation Cephalosporins
Mode Of Action
Cefuroxime is a bactericidal second-generation cephalosporin antibiotic with activity against a wide range of susceptible Gram-positive and Gram-negative organisms, including many strains that produce beta-lactamase enzymes. Cefuroxime works by disrupting the bacterial cell wall synthesis through interference with the transpeptidation process.
Clavulanic acid, a naturally derived beta-lactamase inhibitor produced by Streptomyces clavuligerus, shares a structural similarity with beta-lactam antibiotics. It irreversibly binds to beta-lactamase enzymes, rendering them inactive. This protective action of clavulanic acid shields Cefuroxime from degradation by beta-lactamase enzymes, making it an effective solution for treating bacterial infections caused by beta-lactam-resistant bacteria.
Frequently Asked Questions
What is Co-axet 500 mg+125 mg used for?
Cefuroxime Axetil + Clavulanic Acid is indicated for treating infections caused by sensitive bacteria, including: Pharyngitis/tonsillitis due to Streptococcus pyogenes Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains), or Streptococcus pyogenes Acute bacterial maxillary sinusitis caused by Streptococcus…
What is the dosage of Co-axet 500 mg+125 mg?
Adolescents and adults (13 years and older)- Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 1…
What are the side effects of Co-axet 500 mg+125 mg?
Generally Cefuroxime Axetil + Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pru…
Who should not take Co-axet 500 mg+125 mg?
Cefuroxime-Clavulanic Acid is contraindicated in patients with a known allergy to cephalosporins and in patients with Pseudomembranous Colitis.
What precautions should be taken with Co-axet 500 mg+125 mg?
Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.
Is Co-axet 500 mg+125 mg safe during pregnancy and breastfeeding?
While it's generally advisable to avoid antibiotics during the first trimester of pregnancy, Cefuroxime Axetil + Clavulanic Acid can be used safely in later stages to address urinary and other infections. It is excreted into breast milk in small amounts, but it's essential to consider the potential for sensitizing the infant.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.