Cosentyx150 mg/ml

Cosentyx 150 mg/ml is a human interleukin-17A antagonist indicated for the treatment of: Moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy Adults with active psoriatic arthritis (PsA) Adults with active ankylosing spondylitis (AS)

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis

Cosentyx 150 mg/ml is a human monoclonal antibody that targets IL-17A cytokine to downregulate inflammation in psoriasis, an autoimmune dermatological disease. The pathophysiology of psoriasis has not been fully established, however it is known that dysregulation of innate and adaptive immune responses plays part in the chronic inflammation associated with the disease. IL-17 represents is a six-membered family (IL-17A to F) of pleiotropic pro-inflammatory cytokines, expression of which is found to be elevated in psoriatic skin. These cytokines act on many different cell types and provide defense against different extracellular pathogens causing fungal or bacterial infections. IL-17 cytokines are produced by many cells involved in immune system defense, such as Th17, mast cells, neutrophils, and dendritic cells - all implicated in promoting inflammation. There is evidence linking IL-17 to pathogenesis of multiple autoimmune diseases including rheumatoid arthritis, spondyloarthritis, psoriasis, Crohn's disease, multiple sclerosis, and even atherosclerosis.

Plaque Psoriasis-1. Recommended dosage is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks. For some patients, a dose of 150 mg may be acceptable.Psoriatic Arthritis-1. For psoriatic arthritis patients with coexistent moderate to severe plaque psoriasis, use the dosage and administration for plaque psoriasis.2. For other psoriatic arthritis patients administer with or without a loading dosage. The recommended dosage: With a loading dosage is 150 mg at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter Without a loading dosage is 150 mg every 4 weeks If a patient continues to have active psoriatic arthritis, consider a dosage of 300 mg. Ankylosing Spondylitis-1. Administer with or without a loading dosage. The recommended dosage: With a loading dosage is 150 mg at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter Without a loading dosage is 150 mg every 4 weeks

Plaque Psoriasis-1. Recommended dosage is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks. For some patients, a dose of 150 mg may be acceptable.Psoriatic Arthritis-1. For psoriatic arthritis patients with coexistent moderate to severe plaque psoriasis, use the dosage and administration for plaque psoriasis.2. For other psoriatic arthritis patients administer with or without a loading dosage. The recommended dosage: With a loading dosage is 150 mg at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter Without a loading dosage is 150 mg every 4 weeks If a patient continues to have active psoriatic arthritis, consider a dosage of 300 mg. Ankylosing Spondylitis-1. Administer with or without a loading dosage. The recommended dosage: With a loading dosage is 150 mg at weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter Without a loading dosage is 150 mg every 4 weeks

Live vaccines should not be given with Cosentyx 150 mg/ml

Serious hypersensitivity reaction to Cosentyx 150 mg/ml or to any of the excipients.

Most common adverse reactions (greater than 1%) are nasopharyngitis, diarrhea, and upper respiratory tract infection.

Pregnancy: Limited available human data with Cosentyx 150 mg/ml use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes. In an embryo-fetal development study, no adverse developmental effects were observed in infants born to pregnant monkeys after subcutaneous administration of Cosentyx 150 mg/ml during organogenesis at doses up to 30 times the maximum recommended human doseLactation: It is not known whether Cosentyx 150 mg/ml is excreted in human milk or absorbed systemically after ingestion. There are no data on the effects of Cosentyx 150 mg/ml on the breastfed child or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Cosentyx 150 mg/ml and any potential adverse effects on the breastfed child from Cosentyx 150 mg/ml or from the underlying maternal condition.

Infections: Serious infections have occurred. Caution should be exercised when considering the use of Cosentyx 150 mg/ml in patients with a chronic infection or a history of recurrent infection. If a serious infection develops, discontinue Cosentyx 150 mg/ml until the infection resolves.Tuberculosis (TB): Prior to initiating treatment with Cosentyx 150 mg/ml, evaluate for TB.Inflammatory Bowel Disease: Cases of inflammatory bowel disease were observed in clinical trials. Caution should be exercised when prescribing Cosentyx 150 mg/ml to patients with inflammatory bowel disease.Hypersensitivity Reactions: If an anaphylactic reaction or other serious allergic reaction occurs, discontinue Cosentyx 150 mg/ml immediately and initiate appropriate therapy.

Doses up to 30 mg/kg intravenously have been administered in clinical trials without dose-limiting toxicity. In the event of overdosage, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions and appropriate symptomatic treatment be instituted immediately.

Cosentyx 150 mg/ml Sensoready pens, prefilled syringes and vials must be refrigerated at 2ºC to 8ºC. Keep the product in the original carton to protect from light until the time of use. Do not freeze. To avoid foaming do not shake. Cosentyx 150 mg/ml does not contain a preservative; discard any unused portion.

Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis

Cosentyx 150 mg/ml is a human monoclonal antibody that targets IL-17A cytokine to downregulate inflammation in psoriasis, an autoimmune dermatological disease. The pathophysiology of psoriasis has not been fully established, however it is known that dysregulation of innate and adaptive immune responses plays part in the chronic inflammation associated with the disease. IL-17 represents is a six-membered family (IL-17A to F) of pleiotropic pro-inflammatory cytokines, expression of which is found to be elevated in psoriatic skin. These cytokines act on many different cell types and provide defense against different extracellular pathogens causing fungal or bacterial infections. IL-17 cytokines are produced by many cells involved in immune system defense, such as Th17, mast cells, neutrophils, and dendritic cells - all implicated in promoting inflammation. There is evidence linking IL-17 to pathogenesis of multiple autoimmune diseases including rheumatoid arthritis, spondyloarthritis, psoriasis, Crohn's disease, multiple sclerosis, and even atherosclerosis.

Pregnancy: Limited available human data with Cosentyx 150 mg/ml use in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes. In an embryo-fetal development study, no adverse developmental effects were observed in infants born to pregnant monkeys after subcutaneous administration of Cosentyx 150 mg/ml during organogenesis at doses up to 30 times the maximum recommended human doseLactation: It is not known whether Cosentyx 150 mg/ml is excreted in human milk or absorbed systemically after ingestion. There are no data on the effects of Cosentyx 150 mg/ml on the breastfed child or the effects on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Cosentyx 150 mg/ml and any potential adverse effects on the breastfed child from Cosentyx 150 mg/ml or from the underlying maternal condition.