Cynomin250 mcg/ml
IM/Deep SC Injection
Cyanocobalamin
Jayson Pharma Ltd.
Product Code : 4288
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Medicine overview
Indications of Cynomin 250 mcg/ml
This preparation is indicated in Pernicious anemia,Vitamin B12 deficiency due to low intake from food,Thyrotoxicosis, Hemorrhage, Malignancy, Liver or kidney disease,Gastric bypass surgery, Total or partial gastrectomy, Gluten enteropathy or sprue, Folic acid deficiency, Macrocytic anaemia
Theropeutic Class
Vitamin-B preparations
Pharmacology
Vitamin B12 (Cynomin 250 mcg/ml) is required for the maintenance of normal erthropoiesis, nucleprotein and myelin synthesis, cell reproduction and normal growth; Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism. Plays role in cell replication and hematopoiesis.
Dosage & Administration of Cynomin 250 mcg/ml
Usual Adult Dose for Pernicious AnemiaInitial dose: 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 daysIf clinical improvement and reticulocyte response is seen from the above dosing:
100 mcg every other day for 7 doses, then
100 mcg every 3 to 4 days for 2 to 3 weeks, then
Maintenance dose: 100 to 1000 mcg monthly
Administer concomitant folic acid if needed. Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption.Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally dailyUsual Adult Dose for Schilling Test: 1000 mcg intramuscularly is the flushing doseUsual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily
Dosage of Cynomin 250 mcg/ml
Usual Adult Dose for Pernicious AnemiaInitial dose: 1000 mcg intramuscularly or deep subcutaneous once a day for 6 to 7 daysIf clinical improvement and reticulocyte response is seen from the above dosing:
100 mcg every other day for 7 doses, then
100 mcg every 3 to 4 days for 2 to 3 weeks, then
Maintenance dose: 100 to 1000 mcg monthly
Administer concomitant folic acid if needed. Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption.Usual Adult Dose for B12 Nutritional Deficiency: 25 to 2000 mcg orally dailyUsual Adult Dose for Schilling Test: 1000 mcg intramuscularly is the flushing doseUsual Pediatric Dose for B12 Nutritional Deficiency: 0.5 to 3 mcg daily
Interaction of Cynomin 250 mcg/ml
Absorption reduced by antibiotics, aminosalicylic acid, anticonvulsants, biguanides, cholestyramine, cimetidine, colchicine, K salts, methyldopa.
Contraindications
Leber's disease, tobacco amblyopia.
Side Effects of Cynomin 250 mcg/ml
Arthralgia (12%), Dizziness (12%), Headache (12%), Nasopharyngitis (12%), Anaphylaxis, Angioedema, Congestive heart failure, Peripheral vascular disease,Pulmonary edema, Diarrhea, Dyspepsia, Polycythemia vera, Sore throat, Nervousness, Rhinitis, Glossitis, Hypoesthesia
Pregnancy & Lactation
Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).Lactation: Drug distributed in milk.
Precautions & Warnings
Intensive treatment of B12-deficient megaloblastic anemia may cause hypokalemia and sudden death. Use with caution in patients with Leber optic nerve atrophy. Thrombocytosis may occur with treatment of severe vitamin B12 megaloblastic anemia
Drug Classes
Vitamin-B preparations
Mode Of Action
Vitamin B12 (Cynomin 250 mcg/ml) is required for the maintenance of normal erthropoiesis, nucleprotein and myelin synthesis, cell reproduction and normal growth; Coenzyme; metabolic functions include protein synthesis and carbohydrate metabolism. Plays role in cell replication and hematopoiesis.
Pregnancy
Pregnancy Category A. Adequate and well-controlled human studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).Lactation: Drug distributed in milk.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.