Delkof Plus

Delkof Plus100 ml

Syrup

Dextromethorphan + Pseudoephedrine + Triprolidine

Popular Pharmaceuticals Ltd.

Product Code : 4540
MRP 100.00
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Medicine overview

Indications of Delkof Plus 100 ml

This preparation temporarily relieves these symptoms due to common cold, hay fever (allergic rhinitis) or other upper respiratory allergies: Non-productive cough due to minor throat or bronchial irritation Runny Nose Sneezing Itching of the nose or throat Itchy & watery eyes Nasal congestion

Composition

Each 5 ml syrup contains- Dextromethorphan Hydrobromide BP 20 mg Phenylephrine Hydrochloride BP 10 mg Triprolidine Hydrochloride BP 2.5 mg

Theropeutic Class

Combined cough suppressants

Pharmacology

Dextromethorphan, a centrally-acting antitussive agent, depresses the medullary cough center through sigma receptor stimulation, resulting to decreased sensitivity of cough receptors and interruption of cough impulse transmission.Pseudoephedrine is both an α-and β-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of α-adrenergic receptors of the respiratory mucosa. It also directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.Triprolidine binds to the histamine H1 receptor. This block the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.

Dosage & Administration of Delkof Plus 100 ml

Adults: 2 tea-spoon three times dailyChildren: Over 12 years: 2 tea-spoon three times daily. 6 to 12 years: 1 tea-spoon three times daily. 2 to 5 years: 1/2 tea-spoon three times daily. 6 months to 2 years: 1/4 tea-spoon three times daily or on advice of a physician only.

Dosage of Delkof Plus 100 ml

Adults & Children over 12 years: 1 teaspoonful (5 ml) 4 times a day every 4 hours interval.6-12 years: 1/2 teaspoonful 4 times a day every 4 hours interval.Use in children and adolescents: A physician's advice should be obtained before administering this combination to children less than 6 years.

Interaction of Delkof Plus 100 ml

Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

Contraindications

It should be avoided in patients with liver disease or asthmatic patients and is contraindicated in patients taking monoamine oxidase inhibitors or within 2 weeks from stopping such treatment

Side Effects of Delkof Plus 100 ml

It may cause drowsiness and constipation. Other side effects that may occur include GIT discomfort. No apparent evidence of physical dependence of the morphine type.

Pregnancy & Lactation

There are no specific data on use of this combination during pregnancy. Caution should therefore be exercised by balancing the potential benefits of treatment of the mother against any possible hazards to the developing fetus.

Precautions & Warnings

This preparation may cause drowsiness. If affected, do not drive motor vehicle or operate machinery. Avoid alcoholic drink while on this medication. Use with caution in patients with epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, hypertension, heart disease, diabetes, hyperthyroidism. If symptoms do not improve within one week or accompanied with high fever, consult a physician before continuing use.

Overdose Effects of Delkof Plus 100 ml

In cases of over dosage, hospital admission is strongly advised. Over dosage may produce respiratory depression, paranoid psychosis, delusions, hallucinations and convulsion.

Storage Conditions

Store in a cool and dry place (below 30°C temperature), away from light. Keep out of the reach of children.

Drug Classes

Combined cough suppressants

Mode Of Action

This preparation is a mixture of antitussive, decongestant and antihistamine agent. Dextromethorphan is a safe, effective, non-narcotic antitussive agent which has a central action on the cough centre in the medulla. Although structurally related to Morphine, it has no analgesic and habit forming properties and in general it has little sedative activity. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passage. Phenylephrine is used for the temporary relief of stuffy nose, sinus, and ear symptoms caused by the common cold, flu, allergies, sinusitis & bronchitis. This medication works by decreasing swelling in the nose and ears, thereby lessening discomfort and making it easier to breathe. Triprolidine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing. It is a potent competitive histamine H1-receptor antagonist of the pyrrolidine class with mild central nervous system depressant properties which may cause drowsiness. By antagonizing another natural substance acetylcholine, it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.

Pregnancy

There are no specific data on use of this combination during pregnancy & lactation.
Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.