Depol

Depol125 mg/5 ml

Paracetamol

Desh Pharmaceuticals Ltd.

Product Code : 4618
MRP 16.00
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Paracetamol

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Medicine overview

Indications of Depol 125 mg/5 ml

Depol 125 mg/5 ml is indicated for fever, common cold and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum pain, inflammatory pain and post vaccination pain in children. It is also indicated for rheumatic & osteoarthritic pain and stiffness of joints.

Theropeutic Class

Non opioid analgesics

Pharmacology

Depol 125 mg/5 ml has analgesic and antipyretic properties with weak anti-inflammatory activity. Depol 125 mg/5 ml (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Depol 125 mg/5 ml is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity. Depol 125 mg/5 ml is one of the most widely used, safest and fast acting analgesic. It is well tolerated and free from various side effects of aspirin.

Dosage & Administration of Depol 125 mg/5 ml

Tablet:
  • Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.
  • Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.
Extended Release Tablet:
  • Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours).The tablet must not be crushed.
Syrup/Suspension:
  • Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4 times daily.
  • 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.
  • 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.
  • 6-12 years: 2-A teaspoonful 3 to 4 times daily.
  • Adults: 4-8 teaspoonful 3 to 4 times daily.
Suppository:
  • Children 3-12 months: 60-120 mg,4 times daily.
  • Children 1-5 years: 125-250 mg 4 times daily.
  • Children 6-12 years: 250-500 mg 4 times daily.
  • Adults & children over 12 years: 0.5-1 gm 4 times daily.
Paediatric Drop:
  • Children Upto 3 months: 0.5 ml (40 mg)
  • 4 to 11 months: 1.0 ml (80 mg)
  • 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.
Depol 125 mg/5 ml tablet with actizorb technology: It dissolves up to five times faster than standard Depol 125 mg/5 ml tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.
  • Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.
  • Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

Interaction of Depol 125 mg/5 ml

Patients who have taken barbiturates, tricyclic antidepressants and alcohol may show diminished ability to metabolise large doses of Depol 125 mg/5 ml. Alcohol can increase the hepatotoxicity of Depol 125 mg/5 ml overdosage. Chronic ingestion of anticonvulsants or oral steroid contraceptives induce liver enzymes and may prevent attainment of therapeutic Depol 125 mg/5 ml levels by increasing first-pass metabolism or clearance.

Contraindications

It is contraindicated in known hypersensitivity to Depol 125 mg/5 ml.

Side Effects of Depol 125 mg/5 ml

Side effects of Depol 125 mg/5 ml are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

Pregnancy & Lactation

Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed

Precautions & Warnings

Depol 125 mg/5 ml should be given with caution to patients with impaired kidney or liver function. Depol 125 mg/5 ml should be given with care to patients taking other drugs that affect the liver.

Overdose Effects of Depol 125 mg/5 ml

Symptoms of Depol 125 mg/5 ml overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Drug Classes

Non opioid analgesics

Mode Of Action

Depol 125 mg/5 ml has analgesic and antipyretic properties with weak anti-inflammatory activity. Depol 125 mg/5 ml (Acetaminophen) is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Depol 125 mg/5 ml is a para aminophenol derivative, has analgesic and antipyretic properties with weak anti-inflammatory activity. Depol 125 mg/5 ml is one of the most widely used, safest and fast acting analgesic. It is well tolerated and free from various side effects of aspirin.

Pregnancy

Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed.  Depol 125 mg/5 ml is excreted in breast milk. Maternal ingestion of Depol 125 mg/5 ml in normal therapeutic doses does not appear to present a risk to the nursing infant.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.