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Deflacort30 mg
Square Pharmaceuticals PLC.
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Dezacot30 mg
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Medicine overview
Indications of Dezacot 30 mg
Dezacot 30 mg is indicated in- Anaphylaxisasthmasevere hypersensitivity reactions Rheumatoid arthritisjuvenile chronic arthritispolymyalgia rheumatica Systemic lupus erythematosusdermatomyositismixed connective tissue disease (other than systemic sclerosis)polyartritis nodosasarcoidosis ... Read moreDezacot 30 mg is indicated in- Anaphylaxisasthmasevere hypersensitivity reactions Rheumatoid arthritisjuvenile chronic arthritispolymyalgia rheumatica Systemic lupus erythematosusdermatomyositismixed connective tissue disease (other than systemic sclerosis)polyartritis nodosasarcoidosis Pemphigusbullous pemphigoidpyoderma gangrenosum Minimal change nephrotic syndromeacute interstitial nephritis Rheumatic carditis Ulcerative colitisCrohn's disease Uveitisoptic neuritis Autoimmune haemolytic anaemiaidiopathic thrombocytopenic purpura Acute and lymphatic leukaemiamalignant lymphomamultiple myeloma Immune suppression in transplantation
Theropeutic Class
Glucocorticoids
Pharmacology
Dezacot 30 mg provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis.
Absorption
Besides Dezacot 30 mg decreases the release of certain chemicals that are important in the immune system.
Distribution
By decreasing the release of these chemicals Dezacot 30 mg provides immunosuppressive action.
Dosage & Administration of Dezacot 30 mg
Adults
Dosage:For acute disorders: up to 120 mg/day Dezacot 30 mg may need to be given initially
Notes:Maintenance doses in most conditions are within the range 3-18 mg/day
Rheumatoid arthritis
Dosage:The maintenance dose is usually within the range 3-18 mg/day
Notes:The smallest effective dose should be used and increased if necessary
Bronchial asthma
Dosage:In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled
Notes:For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms
Other conditions
Dosage:The dose of Dezacot 30 mg depends on clinical need titrated to the lowest effective dose for maintenance
Notes:Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg Dezacot 30 mg
Children
Dosage:Alternate day administration may be appropriate
Notes:Doses of Dezacot 30 mg usually lie in the range 0.25-1.5 mg/kg/day
The following ranges provide general guidance
Dosage:Juvenile chronic arthritis: The usual maintenance dose is between 0.25 to 1.0 mg/kg/day
Nephrotic syndrome
Dosage:Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need
Bronchial asthma
Dosage:The initial dose should be between 0.25 - 1.0 mg/kg on alternate days
Dezacot 30 mg withdrawal
Dosage:In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt
Notes:How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced
| Condition | Dosage | Notes |
|---|---|---|
| Adults | For acute disorders: up to 120 mg/day Dezacot 30 mg may need to be given initially | Maintenance doses in most conditions are within the range 3-18 mg/day |
| Rheumatoid arthritis | The maintenance dose is usually within the range 3-18 mg/day | The smallest effective dose should be used and increased if necessary |
| Bronchial asthma | In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled | For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms |
| Other conditions | The dose of Dezacot 30 mg depends on clinical need titrated to the lowest effective dose for maintenance | Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg Dezacot 30 mg |
| Children | Alternate day administration may be appropriate | Doses of Dezacot 30 mg usually lie in the range 0.25-1.5 mg/kg/day |
| The following ranges provide general guidance | Juvenile chronic arthritis: The usual maintenance dose is between 0.25 to 1.0 mg/kg/day | |
| Nephrotic syndrome | Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need | |
| Bronchial asthma | The initial dose should be between 0.25 - 1.0 mg/kg on alternate days | |
| Dezacot 30 mg withdrawal | In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt | How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced |
Dosage of Dezacot 30 mg
Adults- For acute disorders
Dosage:Up to 120 mg/day Dezacot 30 mg may need to be given initially
Notes:Maintenance doses in most conditions are within the range of 3-18 mg/day
Rheumatoid arthritis
Dosage:The maintenance dose is usually within the range of 3-18 mg/day
Notes:The smallest effective dose should be used and increased if necessary
Bronchial asthma
Dosage:In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled
Notes:For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms
Other conditions
Dosage:The dose of Dezacot 30 mg depends on clinical need titrated to the lowest effective dose for maintenance
Notes:Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg
Children
Dosage:There has been limited exposure of children to Dezacot 30 mg in clinical trials
Notes:In children, the indications for glucocorticoids arethe same as for adults, but it is important that the lowest effective dosage is used. Alternate day administration may be appropriate. Doses of Dezacot 30 mg usually lie in the range 0.25-1.5 mg/kg/day
The following ranges provide general guidance
Dosage:Juvenile chronic arthritis: The usual maintenance dose is between 0.25-1.0 mg/kg/day
Nephrotic syndrome
Dosage:Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need
Bronchial asthma
Dosage:On the basis of the potency ratio, the initial dose should be between 0.25-1.0 mg/kg on alternate days
Dezacot 30 mg withdrawal
Dosage:In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt
Notes:How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced
| Condition | Dosage | Notes |
|---|---|---|
| Adults- For acute disorders | Up to 120 mg/day Dezacot 30 mg may need to be given initially | Maintenance doses in most conditions are within the range of 3-18 mg/day |
| Rheumatoid arthritis | The maintenance dose is usually within the range of 3-18 mg/day | The smallest effective dose should be used and increased if necessary |
| Bronchial asthma | In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled | For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms |
| Other conditions | The dose of Dezacot 30 mg depends on clinical need titrated to the lowest effective dose for maintenance | Starting doses may be estimated on the basis of ratio of 5 mg prednisone or prednisolone to 6 mg |
| Children | There has been limited exposure of children to Dezacot 30 mg in clinical trials | In children, the indications for glucocorticoids arethe same as for adults, but it is important that the lowest effective dosage is used. Alternate day administration may be appropriate. Doses of Dezacot 30 mg usually lie in the range 0.25-1.5 mg/kg/day |
| The following ranges provide general guidance | Juvenile chronic arthritis: The usual maintenance dose is between 0.25-1.0 mg/kg/day | |
| Nephrotic syndrome | Initial dose of usually 1.5 mg/kg/day followed by down titration according to clinical need | |
| Bronchial asthma | On the basis of the potency ratio, the initial dose should be between 0.25-1.0 mg/kg on alternate days | |
| Dezacot 30 mg withdrawal | In patients who have received more than physiological doses of systemic corticosteroids (approximately 9 mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt | How dose reduction should be carried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced |
Interaction of Dezacot 30 mg
Dezacot 30 mg is metabolized in the liver. It is recommended to increase the maintenance dose of Dezacot 30 mg if drugs which are liver enzyme inducers are co-administered, e.g. rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone and aminoglutethimide. For drugs which inhibit liver enzymes, (e.g. ketoconazole) it may be possible to reduce the maintenance dose of Dezacot 30 mg.
Contraindications
Hypersensitivity to or any of the ingredients. Patients receiving live virus immunization.
Side Effects of Dezacot 30 mg
GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent Ml, thromboembolism.
Pregnancy & Lactation
Use in pregnancy: Dezacot 30 mg does cross the placenta. When administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intra-uterine growth retardation. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks.Use in lactation: Corticosteroids are excreted in breast milk. Doses up to 50 mg daily of Dezacot 30 mg are unlikely to cause systemic effects in the infant.
Precautions & Warnings
The following clinical conditions require special caution and frequent patient monitoring is necessary-
Cardiac disease or congestive heart failure (except in the presence of active rheumatic carditis), hypertension, thromboembolic disorders. Glucocorticoids can cause salt and water retention and increased excretion of potassium. Dietary salt restriction and potassium supplementation may be necessary.
Gastritis or oesophagitis, diverticulitis, ulcerative colitis if there is the probability of impending perforation, abscess or pyogenic infections, fresh intestinal anastomosis, active or latent peptic ulcer.
Diabetes mellitus or family history, osteoporosis, myasthenia gravis, renal insufficiency.
Emotional instability or psychotic tendency, epilepsy.
Previous corticosteroid-induced myopathy.
Liver failure.
Hypothyroidism and cirrhosis, which may increase the glucocorticoid effect.
Ocular herpes simplex because of possible corneal perforation.
Overdose Effects of Dezacot 30 mg
In patients who have received more than physiological doses of systemic corticosteroids (approximately 9mg per day or equivalent) for greater than 3 weeks, withdrawal should not be abrupt. How dose reduction should becarried out depends largely on whether the disease is likely to relapse as the dose of systemic corticosteroids is reduced.
Storage Conditions
Store in a cool (below 25°C) and dry place, protected from light & moisture. Keep out of the reach of children.
Use In Special Populations
Elderly: In elderly patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.Hepatic impairment: In patients with hepatic impairment, blood levels of Dezacot 30 mg may be increased. Therefore the dose of Dezacot 30 mg should be carefully monitored and adjusted to the minimum effective dose.Renal impairment: In renal impaired patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.
Drug Classes
Glucocorticoids
Mode Of Action
Dezacot 30 mg provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis. Besides Dezacot 30 mg decreases the release of certain chemicals that are important in the immune system. By decreasing the release of these chemicals Dezacot 30 mg provides immunosuppressive action.
Pregnancy
Pregnancy: Dezacot 30 mg does cross the placenta. However, when administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intrauterine growth retardation. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks.Nursing Mother: Corticosteroids are excreted in breast milk, although no data are available for Dezacot 30 mg. Doses of up to 50 mg daily of Dezacot 30 mg are unlikely to cause systemic effects in the infant. Infants of mothers taking higher doses than this may have a degree of adrenal suppression but the benefits of breastfeeding are likely to outweigh any theoretical risk.
Pediatric Uses
Hepatic Impairment: In patients with hepatic impairment, blood levels of may be increased. Therefore the dose of Dezacot 30 mg should be carefully monitored and adjusted to the minimum effective dose.Renal Impairment: In renally impaired patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary.Elderly: In elderly patients, no special precautions other than those usually adopted in patients receiving glucocorticoid therapy are necessary. The common adverse effects of systemic corticosteroids may be associated with more serious consequences in old age.
Frequently Asked Questions
What is Dezacot 30 mg used for?
Deflazacort is indicated in- Anaphylaxis, asthma, severe hypersensitivity reactions Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyartritis nodosa, sarcoidosis ... Read moreDeflazacort is indicated in- Anaphylaxis, asthma, severe hypersensitivity reactions R…
What is the dosage of Dezacot 30 mg?
Adults- For acute disorders: Up to 120 mg/day Deflazacort may need to be given initially. Maintenance doses in most conditions are within the range of 3-18 mg/day. Rheumatoid arthritis: The maintenance dose is usually within the range of 3-18 mg/day. The smallest effective dose should be used and increased if necessary. Bronchial asthma: In the treatment of an acute attack, high doses of 48-72 mg/…
What are the side effects of Dezacot 30 mg?
GI disturbances, musculoskeletal, endocrine, neuropsychiatric, ophthalmic, fluid and electrolyte disturbances; susceptible to infection, impaired healing, hypersensitivity, skin atrophy, striae, telangiectasia, acne, myocardial rupture following recent Ml, thromboembolism.
Who should not take Dezacot 30 mg?
Hypersensitivity to or any of the ingredients. Patients receiving live virus immunization.
What precautions should be taken with Dezacot 30 mg?
The following clinical conditions require special caution and frequent patient monitoring is necessary- Cardiac disease or congestive heart failure (except in the presence of active rheumatic carditis), hypertension, thromboembolic disorders. Glucocorticoids can cause salt and water retention and increased excretion of potassium. Dietary salt restriction and potassium supplementation may be necess…
Is Dezacot 30 mg safe during pregnancy and breastfeeding?
Use in pregnancy: Deflazacort does cross the placenta. When administered for prolonged periods or repeatedly during pregnancy, corticosteroids may increase the risk of intra-uterine growth retardation. As with all drugs, corticosteroids should only be prescribed when the benefits to the mother and child outweigh the risks.Use in lactation: Corticosteroids are excreted in breast milk. Doses up to 5…
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.